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Smim22 Gene Detail
Summary
  • Symbol
    Smim22
  • Name
    small integral membrane protein 22
  • Synonyms
    Gm5480
  • Feature Type
    protein coding gene
  • IDs
    MGI:3643379
    NCBI Gene: 432995
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:4825152-4826173 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 2.49 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    116 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3643379
 protein coding gene Chr16:4825152-4826173 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022480
 protein coding gene Chr16:1533431-1534452 (+)
A/J MGP_AJ_G0022442
 protein coding gene Chr16:1341704-1342725 (+)
AKR/J MGP_AKRJ_G0022419
 protein coding gene Chr16:1537229-1538250 (+)
BALB/cJ MGP_BALBcJ_G0022447
 protein coding gene Chr16:1494470-1495491 (+)
C3H/HeJ MGP_C3HHeJ_G0022214
 protein coding gene Chr16:1558856-1559877 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022896
 protein coding gene Chr16:1619551-1620572 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020417
 protein coding gene Chr16:1274292-1275330 (+)
CAST/EiJ MGP_CASTEiJ_G0021740
 protein coding gene Chr16:1563540-1564560 (+)
CBA/J MGP_CBAJ_G0022183
 protein coding gene Chr16:1716288-1717309 (+)
DBA/2J MGP_DBA2J_G0022314
 protein coding gene Chr16:1442730-1443751 (+)
FVB/NJ MGP_FVBNJ_G0022289
 protein coding gene Chr16:1437279-1438300 (+)
LP/J MGP_LPJ_G0022382
 protein coding gene Chr16:1519718-1520739 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022311
 protein coding gene Chr16:1552490-1553511 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022908
 protein coding gene Chr16:1509578-1510599 (+)
PWK/PhJ MGP_PWKPhJ_G0021480
 protein coding gene Chr16:1519680-1520694 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021311
 protein coding gene Chr16:1597283-1598300 (+)
WSB/EiJ MGP_WSBEiJ_G0021789
 protein coding gene Chr16:1526843-1527879 (+)



Homology
more
  • Human Ortholog
    SMIM22, small integral membrane protein 22
  • Vertebrate Orthologs
    1
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SMIM22, small integral membrane protein 22
  • Synonyms
    CASIMO1
  • Links
    NCBI Gene ID: 440335
    UniProt: K7EJ46

  • Chr Location
    16p13.3; chr16:4788397-4796491 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    6
  • GO References
    2
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    712
  • Tissues
    4
  • cDNA Data
    4
  • Literature Summary
    1
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 432995 NCBI Gene Model | MGI Sequence Detail 1022 C57BL/6J ±  kb
transcript NM_001253796 RefSeq | MGI Sequence Detail 462 C57BL/6  
polypeptide NP_001240725 RefSeq | MGI Sequence Detail 91 C57BL/6  
For the selected sequence
Protein
Information
less
  • UniProt
    2 Sequences
  • InterPro Domains
    IPR053081 Small Integral Membrane Modulators
    IPR031671 Small integral membrane protein 5/18/22
Molecular
Reagents
less
  • All nucleic 4
    cDNA 4
References
more
  • Summaries
    All 16
    Developmental Gene Expression 1
    Gene Ontology 2
    Phenotypes 4
  • Earliest
    J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
  • Latest
    J:143778 Tamplin OJ, et al., Integrated microarray and ChIP analysis identifies multiple Foxa2 dependent target genes in the notochord. Dev Biol. 2011 Dec 15;360(2):415-25
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory