About   Help   FAQ
Ddx43 Gene Detail
Summary
  • Symbol
    Ddx43
  • Name
    DEAD (Asp-Glu-Ala-Asp) box polypeptide 43
  • Synonyms
    ENSMUSG00000070291, OTTMUSG00000019690
  • Feature Type
    protein coding gene
  • IDs
    MGI:3642857
    NCBI Gene: 100048658
  • Gene Overview
    MyGene.info: DDX43
Location & Maps
more
  • Sequence Map
    Chr9:78395777-78423587 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      27811 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 43.65 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    DDX43, DEAD-box helicase 43
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DDX43, DEAD-box helicase 43
    Orthology source: HomoloGene
  • Synonyms
    CT13, HAGE
  • Links
    NCBI Gene ID: 55510
    neXtProt AC: NX_Q9NXZ2

  • Chr Location
    6q13; chr6:73394562-73417566 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotype references
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    1
  • Gene trapped
    2
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    2 involving Ddx43
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019690 VEGA Gene Model | MGI Sequence Detail 27811 C57BL/6J ±  kb
transcript OTTMUST00000047137 VEGA | MGI Sequence Detail 2207 Not Applicable  
polypeptide OTTMUSP00000021290 VEGA | MGI Sequence Detail 646 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    80 from dbSNP Build 142
Protein
Information
less
  • UniProt
    1 Sequence
  • InterPro Domains
    IPR000629 ATP-dependent RNA helicase DEAD-box, conserved site
    IPR011545 DEAD/DEAH box helicase domain
    IPR001650 Helicase, C-terminal
    IPR014001 Helicase superfamily 1/2, ATP-binding domain
    IPR004087 K Homology domain
    IPR004088 K Homology domain, type 1
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR014014 RNA helicase, DEAD-box type, Q motif
Molecular
Reagents
less
  • All nucleic 2
    cDNA 2

    Microarray probesets 3
References
more
  • Summaries
    All 21
    Gene Ontology 2
    Phenotypes 12
  • Earliest
    J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/17/2016
MGI 6.05
The Jackson Laboratory