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Nps Gene Detail
Summary
  • Symbol
    Nps
  • Name
    neuropeptide S
  • Synonyms
    ENSMUSG00000073804
  • Feature Type
    protein coding gene
  • IDs
    MGI:3642232
    NCBI Gene: 100043254
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:134870348-134874671 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 7, 81.27 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    61 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3642232
protein coding gene Chr7:134860432-134874671 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033131
protein coding gene Chr7:140110792-140115095 (+)
A/J MGP_AJ_G0033113
protein coding gene Chr7:136210019-136214322 (+)
AKR/J MGP_AKRJ_G0033045
protein coding gene Chr7:139851526-139855763 (+)
BALB/cJ MGP_BALBcJ_G0033114
protein coding gene Chr7:135954209-135958512 (+)
C3H/HeJ MGP_C3HHeJ_G0032828
protein coding gene Chr7:139711554-139715857 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033625
protein coding gene Chr7:145414146-145418449 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030598
protein coding gene Chr7:137444583-137448888 (+)
CAST/EiJ MGP_CASTEiJ_G0032158
protein coding gene Chr7:131821356-131825583 (+)
CBA/J MGP_CBAJ_G0032801
protein coding gene Chr7:150310546-150314765 (+)
DBA/2J MGP_DBA2J_G0032953
protein coding gene Chr7:134211186-134215415 (+)
FVB/NJ MGP_FVBNJ_G0032906
protein coding gene Chr7:134059318-134063545 (+)
LP/J MGP_LPJ_G0033047
protein coding gene Chr7:141647118-141651421 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032938
protein coding gene Chr7:151160466-151164769 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033645
protein coding gene Chr7:138886011-138890232 (+)
PWK/PhJ MGP_PWKPhJ_G0031864
protein coding gene Chr7:127266728-127271019 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031710
protein coding gene Chr7:125653924-125658281 (+)
WSB/EiJ MGP_WSBEiJ_G0032269
protein coding gene Chr7:139743468-139747771 (+)



Homology
more
  • Human Ortholog
    NPS, neuropeptide S
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NPS, neuropeptide S
  • Links
    NCBI Gene ID: 594857
    neXtProt AC: NX_P0C0P6
    UniProt: P0C0P6

  • Chr Location
    chr10:127549309-127553540 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele display decreased exploratory behavior and increased anxiety related responses.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 100043254 NCBI Gene Model | MGI Sequence Detail 4324 C57BL/6J ±  kb
transcript NM_001163611 RefSeq | MGI Sequence Detail 860 C57BL/6  
polypeptide P0C0P8 UniProt | EBI | MGI Sequence Detail 89 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less

  • Microarray probesets 1
References
more
  • Summaries
    All 21
    Gene Ontology 6
    Phenotypes 5
  • Earliest
    J:150446 Han RW, et al., Neuropeptide S facilitates spatial memory and mitigates spatial memory impairment induced by N-methyl-d-aspartate receptor antagonist in mice. Neurosci Lett. 2009 May 8;455(1):74-7
  • Latest
    J:341778 Garau C, et al., Neuropeptide S Encodes Stimulus Salience in the Paraventricular Thalamus. Neuroscience. 2022 Jun 13;496:83-95

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory