Krtap12-23 Gene Detail

Summary

• Symbol
  Krtap12-23
• Name
  keratin associated protein 12-23
• Synonyms
  Gm10272

• Feature Type
  protein coding gene
• IDs
  MGI:3642183
  NCBI Gene: 16697
• Alliance
  gene page
• Transcription Start Sites
  1 TSS

Location &
Maps

• Sequence Map
  Chr10:77542460-77542809 bp, + strand

  From Ensembl annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 10, 39.72 cM
• Mapping Data
  1 experiment

Strain
Comparison

• SNPs within 2kb
  39 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3642183	protein coding gene	Chr10:77542423-77542820 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017403	protein coding gene	Chr10:78051751-78052083 (+)
A/J	MGP_AJ_G0017379	protein coding gene	Chr10:75331368-75331700 (+)
AKR/J	MGP_AKRJ_G0017341	protein coding gene	Chr10:77341207-77341539 (+)
BALB/cJ	MGP_BALBcJ_G0017340	protein coding gene	Chr10:75525262-75525594 (+)
C3H/HeJ	MGP_C3HHeJ_G0017164	protein coding gene	Chr10:77424860-77425192 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017798	protein coding gene	Chr10:80800929-80801261 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015487	protein coding gene	Chr10:71762738-71763100 (+)
CAST/EiJ	MGP_CASTEiJ_G0016734	protein coding gene	Chr10:77788535-77788897 (+)
CBA/J	MGP_CBAJ_G0017136	protein coding gene	Chr10:83899876-83900208 (+)
DBA/2J	MGP_DBA2J_G0017241	protein coding gene	Chr10:74606855-74607187 (+)
FVB/NJ	MGP_FVBNJ_G0017233	protein coding gene	Chr10:73784026-73784358 (+)
LP/J	MGP_LPJ_G0017314	protein coding gene	Chr10:78512682-78513014 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017262	protein coding gene	Chr10:85935996-85936328 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017837	protein coding gene	Chr10:77430930-77431262 (+)
PWK/PhJ	MGP_PWKPhJ_G0016517	protein coding gene	Chr10:74490504-74490827 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016301	protein coding gene	Chr10:76683539-76683901 (+)
WSB/EiJ	MGP_WSBEiJ_G0016796	protein coding gene	Chr10:77403942-77404274 (+)

Homology

• Human Ortholog
  KRTAP12-1, keratin associated protein 12-1

• Vertebrate Orthologs
  5

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  KRTAP12-1, keratin associated protein 12-1
  
• Synonyms
  KAP12.1, KRTAP12.1
• Links
  HGNC:20529

  NCBI Gene ID: 353332

  neXtProt AC: NX_P59990

  UniProt: P59990

  
  
• Chr Location
  21q22.3; chr21:44681576-44682163 (-)  GRCh38

---

• Human Ortholog
  KRTAP12-2, keratin associated protein 12-2
  
• Synonyms
  KAP12.2, KRTAP12.2
• Links
  HGNC:20530

  NCBI Gene ID: 353323

  neXtProt AC: NX_P59991

  UniProt: P59991

  
  
• Chr Location
  21q22.3; chr21:44666189-44666927 (-)  GRCh38

---

• Human Ortholog
  KRTAP12-3, keratin associated protein 12-3
  
• Synonyms
  KRTAP12.3
• Links
  HGNC:20531

  NCBI Gene ID: 386683

  neXtProt AC: NX_P60328

  UniProt: P60328

  
  
• Chr Location
  21q22.3; chr21:44657932-44658341 (+)  GRCh38

---

• MGI Vertebrate Homology
  Krtap12-23 stringent orthology
  3 human;1 mouse;2 rat
  
• HCOP
  vertebrate homology predictions: KRTAP12-1, KRTAP12-2, KRTAP12-3
• Gene Tree
  Krtap12-23
  

Human Diseases

• References
  2 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  26 phenotype references
  

• All Mutations and Alleles
  4
• Chemically induced (other)
  1
• Targeted
  3
• Genomic Mutations
  4 involving Krtap12-23
• Incidental Mutations
  Mutagenetix , APF
• Find Mice (IMSR)
  6 strains or lines available

Gene Ontology
(GO)
Classifications

• All GO Annotations
  1
• GO References
  1

Expression

• Assay Results
  706
• cDNA Data
  1

Tissue x Stage Matrix

• Other Mouse Links
  GEO
  Expression Atlas

Sequences &
Gene Models

• All Sequences
  26
• RefSeq
  2
• UniProt
  1

• Ensembl
  ENSMUSG00000069584 (Evidence)
• NCBI Gene
  16697

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000069584	Ensembl Gene Model | MGI Sequence Detail	350	C57BL/6J
transcript	ENSMUST00000092371	Ensembl | MGI Sequence Detail	350	Not Applicable
polypeptide	ENSMUSP00000090025	Ensembl | MGI Sequence Detail	110	Not Applicable

Protein
Information

• UniProt
  1 Sequence
• InterPro Domains
  IPR002494 Keratin-associated protein

Molecular
Reagents

• All nucleic 1

  cDNA 1

References

• Summaries
  All 35

  Diseases 2

  Gene Ontology 1

  Phenotypes 26
• Earliest
  J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
• Latest
  J:341136 Muza PM, et al., Cognitive impairments in a Down syndrome model with abnormal hippocampal and prefrontal dynamics and cytoarchitecture. iScience. 2023 Feb 17;26(2):106073

TSS for Krtap12-23:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr94281	Chr10:77542422-77542425 (+)	-36 bp