About   Help   FAQ
Qrfp Gene Detail
Summary
  • Symbol
    Qrfp
  • Name
    pyroglutamylated RFamide peptide
  • Synonyms
    P518, QRFP
  • Feature Type
    protein coding gene
  • IDs
    MGI:3630329
    NCBI Gene: 227717
  • Gene Overview
    MyGene.info: QRFP
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr2:31806168-31810580 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 21.89 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    16 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3630329
protein coding gene Chr2:31806166-31810580 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025590
protein coding gene Chr2:30184901-30190979 (-)
A/J MGP_AJ_G0025568
protein coding gene Chr2:28934687-28939100 (-)
AKR/J MGP_AKRJ_G0025537
protein coding gene Chr2:29929529-29933942 (-)
BALB/cJ MGP_BALBcJ_G0025564
protein coding gene Chr2:29061855-29066302 (-)
C3H/HeJ MGP_C3HHeJ_G0025325
protein coding gene Chr2:29843366-29848967 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026009
protein coding gene Chr2:31127045-31131448 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023417
protein coding gene Chr2:27679388-27683747 (-)
CAST/EiJ MGP_CASTEiJ_G0024787
protein coding gene Chr2:29786650-29793002 (-)
CBA/J MGP_CBAJ_G0025302
protein coding gene Chr2:32259186-32263586 (-)
DBA/2J MGP_DBA2J_G0025435
protein coding gene Chr2:28708999-28713412 (-)
FVB/NJ MGP_FVBNJ_G0025398
protein coding gene Chr2:28559919-28563946 (-)
LP/J MGP_LPJ_G0025521
protein coding gene Chr2:30058828-30064709 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025428
protein coding gene Chr2:31994432-32000318 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026067
protein coding gene Chr2:29844263-29849354 (-)
PWK/PhJ MGP_PWKPhJ_G0024534
protein coding gene Chr2:28599444-28603990 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024334
protein coding gene Chr2:29981950-29988366 (-)
WSB/EiJ MGP_WSBEiJ_G0024855
protein coding gene Chr2:30018968-30024838 (-)



Homology
more
  • Human Ortholog
    QRFP, pyroglutamylated RFamide peptide
  • Vertebrate Orthologs
    8
  • Human Ortholog
    QRFP, pyroglutamylated RFamide peptide
    Orthology source: HomoloGene, HGNC
  • Synonyms
    26RFa, P518
  • Links
    NCBI Gene ID: 347148
    neXtProt AC: NX_P83859
    UniProt: P83859

  • Chr Location
    9q34.12; chr9:130893428-130896812 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 1 allele in 1 genetic background
    2 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased body weight and fat mass, hypophagia, decreased serum leptin level, hypoactivity, increased anxiety-like behavior, and decreased wakefulness in the early hours of the dark period.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 227717 NCBI Gene Model | MGI Sequence Detail 4413 C57BL/6J ±  kb
transcript NM_183424 RefSeq | MGI Sequence Detail 2925 C57BL/6  
polypeptide Q8CE23 UniProt | EBI | MGI Sequence Detail 124 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 5
    cDNA 5

    Microarray probesets 1
References
more
  • Summaries
    All 28
    Gene Ontology 6
    Phenotypes 2
  • Earliest
    J:84528 Jiang Y, et al., Identification and characterization of a novel RF-amide peptide ligand for orphan G-protein-coupled receptor SP9155. J Biol Chem. 2003 Jul 25;278(30):27652-7
  • Latest
    J:250913 Okamoto K, et al., QRFP-Deficient Mice Are Hypophagic, Lean, Hypoactive and Exhibit Increased Anxiety-Like Behavior. PLoS One. 2016;11(11):e0164716

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/06/2018
MGI 6.13
The Jackson Laboratory