Krt74 Pseudogene Detail

Summary

• Symbol
  Krt74
• Name
  keratin 74
• Synonyms
  Kb37

• Feature Type
  pseudogene
• IDs
  MGI:3629975
  NCBI Gene: 406222
• Alliance
  gene page
• Transcription Start Sites
  1 TSS

Location &
Maps

• Sequence Map
  Chr15:101754259-101763504 bp, - strand
• From NCBI annotation of GRCm38
  

  View this region in JBrowse
  
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 15, 57.01 cM
• Mapping Data
  1 experiment

Strain
Comparison

• SNPs within 2kb
  97 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3629975	pseudogene	Chr15:101754259-101763504 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0022385	protein coding gene	Chr15:103882143-103890411 (-)
A/J	MGP_AJ_G0022348	protein coding gene	Chr15:99782814-99791201 (-)
AKR/J	MGP_AKRJ_G0022323	protein coding gene	Chr15:102812956-102821434 (-)
BALB/cJ	MGP_BALBcJ_G0022351	protein coding gene	Chr15:99855422-99863712 (-)
C3H/HeJ	MGP_C3HHeJ_G0022118	protein coding gene	Chr15:102891257-102900474 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0022800	protein coding gene	Chr15:107736443-107744864 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020323	protein coding gene	Chr15:95593558-95601637 (-)
CAST/EiJ	MGP_CASTEiJ_G0021644	protein coding gene	Chr15:103735545-103743734 (-)
CBA/J	MGP_CBAJ_G0022087	protein coding gene	Chr15:111497477-111508762 (-)
DBA/2J	MGP_DBA2J_G0022218	protein coding gene	Chr15:99095210-99104250 (-)
FVB/NJ	MGP_FVBNJ_G0022194	protein coding gene	Chr15:98151520-98160518 (-)
LP/J	MGP_LPJ_G0022287	protein coding gene	Chr15:104038117-104046373 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022216	protein coding gene	Chr15:115127937-115136335 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022812	protein coding gene	Chr15:102838337-102846745 (-)
PWK/PhJ	MGP_PWKPhJ_G0021384	protein coding gene	Chr15:99239301-99247504 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0021216	protein coding gene	Chr15:102683816-102691919 (-)
WSB/EiJ	MGP_WSBEiJ_G0021694	protein coding gene	Chr15:103474710-103484344 (-)

Homology

• Human Ortholog
  KRT74, keratin 74

• Human Ortholog
  KRT74, keratin 74
  Orthology source: HGNC
• Synonyms
  ADWH, HTSS2, HYPT3, K6IRS4, KRT5C, KRT6IRS4
• Links
  HGNC:28929

  NCBI Gene ID: 121391

  neXtProt AC: NX_Q7RTS7

  UniProt: Q7RTS7

  
  
• Chr Location
  12q13.13; chr12:52565819-52573825 (-)  GRCh38.p7

---

• HCOP
  human homology predictions: KRT74
• Gene Tree
  Krt74
  

Human Diseases

• Diseases
  1 with human KRT74 associations

				Human Disease	Mouse Models
				hypotrichosis 3 IDs hypotrichosis 3       DOID:0110700 OMIM:613981

Click on a disease name to see all genes associated with that disease.

• References
  1 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  30 phenotype references
  

• All Mutations and Alleles
  8
• Chemically induced (other)
  1
• Radiation induced
  2
• Targeted
  5
• Genomic Mutations
  4 involving Krt74
• Incidental Mutations
  Mutagenetix , APF
• Find Mice (IMSR)
  23 strains or lines available

Expression

• Assay Results
  3
• Tissues
  3
• cDNA Data
  1
• Literature Summary
  1

Images

Tissue x Stage Matrix

• Other Mouse Links
  GEO
  Expression Atlas

Interactions

• Krt74 interacts with 32 markers (Mir15a, Mir15b, Mir16-1, ...) View All

Sequences &
Gene Models

• All Sequences
  26
• RefSeq
  1
• UniProt
  1
• UniGene
  359153

• Ensembl
  ENSMUSG00000067596 (Evidence)
• NCBI Gene
  406222

Representative Sequences			Length	Strain/Species
genomic	406222	NCBI Gene Model | MGI Sequence Detail	9246	C57BL/6J
transcript	NR_033444	RefSeq | MGI Sequence Detail	1589	Not Specified
polypeptide	Q6IFZ9	UniProt | EBI | MGI Sequence Detail	495	Not Applicable

Protein
Information

• UniProt
  1 Sequence
• Protein Ontology
  PR:000009489 keratin, type II cytoskeletal 74
  (term hierarchy)
• InterPro Domains
  IPR018039 Intermediate filament protein, conserved site
  IPR039008 Intermediate filament, rod domain
  IPR003054 Keratin, type II
  IPR032444 Keratin type II head

Molecular
Reagents

• All nucleic 1

  cDNA 1

References

• Summaries
  All 43

  Developmental Gene Expression 1

  Diseases 1

  Phenotypes 30
• Earliest
  J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
• Latest
  J:236599 Dickinson ME, et al., High-throughput discovery of novel developmental phenotypes. Nature. 2016 Sep 14;537(7621):508-514

TSS for Krt74:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr136610	Chr15:101763557-101763566 (-)	-58 bp