Krt74 Pseudogene Detail

Summary

• Symbol
  Krt74
• Name
  keratin 74
• Synonyms
  Kb37

• Feature Type
  pseudogene
• IDs
  MGI:3629975
  NCBI Gene: 406222
• Alliance
  gene page
• Transcription Start Sites
  1 TSS

Location &
Maps

• Sequence Map
  Chr15:101754259-101763504 bp, - strand
• From NCBI annotation of GRCm38
  

  View this region in JBrowse
  
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 15, 57.01 cM
• Mapping Data
  1 experiment

Strain
Comparison

• SNPs within 2kb
  97 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3629975	pseudogene	Chr15:101754259-101763504 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0022385	protein coding gene	Chr15:103882143-103890411 (-)
A/J	MGP_AJ_G0022348	protein coding gene	Chr15:99782814-99791201 (-)
AKR/J	MGP_AKRJ_G0022323	protein coding gene	Chr15:102812956-102821434 (-)
BALB/cJ	MGP_BALBcJ_G0022351	protein coding gene	Chr15:99855422-99863712 (-)
C3H/HeJ	MGP_C3HHeJ_G0022118	protein coding gene	Chr15:102891257-102900474 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0022800	protein coding gene	Chr15:107736443-107744864 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020323	protein coding gene	Chr15:95593558-95601637 (-)
CAST/EiJ	MGP_CASTEiJ_G0021644	protein coding gene	Chr15:103735545-103743734 (-)
CBA/J	MGP_CBAJ_G0022087	protein coding gene	Chr15:111497477-111508762 (-)
DBA/2J	MGP_DBA2J_G0022218	protein coding gene	Chr15:99095210-99104250 (-)
FVB/NJ	MGP_FVBNJ_G0022194	protein coding gene	Chr15:98151520-98160518 (-)
LP/J	MGP_LPJ_G0022287	protein coding gene	Chr15:104038117-104046373 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022216	protein coding gene	Chr15:115127937-115136335 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022812	protein coding gene	Chr15:102838337-102846745 (-)
PWK/PhJ	MGP_PWKPhJ_G0021384	protein coding gene	Chr15:99239301-99247504 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0021216	protein coding gene	Chr15:102683816-102691919 (-)
WSB/EiJ	MGP_WSBEiJ_G0021694	protein coding gene	Chr15:103474710-103484344 (-)

Homology

• Human Ortholog
  KRT74, keratin 74

• Human Ortholog
  KRT74, keratin 74
  Orthology source: HGNC
• Synonyms
  ADWH, HTSS2, HYPT3, K6IRS4, KRT5C, KRT6IRS4
• Links
  HGNC:28929

  NCBI Gene ID: 121391

  neXtProt AC: NX_Q7RTS7

  UniProt: Q7RTS7

  
  
• Chr Location
  12q13.13; chr12:52565819-52573825 (-)  GRCh38.p7

---

• HCOP
  human homology predictions: KRT74
• Gene Tree
  Krt74
  

Human Diseases

• Diseases
  1 with human KRT74 associations

				Human Disease	Mouse Models
				hypotrichosis 3 IDs hypotrichosis 3       DOID:0110700 OMIM:613981

Click on a disease name to see all genes associated with that disease.

• References
  1 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  30 phenotype references
  

• All Mutations and Alleles
  8
• Chemically induced (other)
  1
• Radiation induced
  2
• Targeted
  5
• Genomic Mutations
  4 involving Krt74
• Incidental Mutations
  Mutagenetix , APF
• Find Mice (IMSR)
  23 strains or lines available

Expression

• Assay Results
  3
• Tissues
  3
• cDNA Data
  1
• Literature Summary
  1

Images

Tissue x Stage Matrix

• Other Mouse Links
  GEO
  Expression Atlas

Interactions

• Krt74 interacts with 32 markers (Mir15a, Mir15b, Mir16-1, ...) View All

Sequences &
Gene Models

• All Sequences
  26
• RefSeq
  1
• UniProt
  1
• UniGene
  359153

• Ensembl
  ENSMUSG00000067596 (Evidence)
• NCBI Gene
  406222

Representative Sequences			Length	Strain/Species
genomic	406222	NCBI Gene Model | MGI Sequence Detail	9246	C57BL/6J
transcript	NR_033444	RefSeq | MGI Sequence Detail	1589	Not Specified
polypeptide	Q6IFZ9	UniProt | EBI | MGI Sequence Detail	495	Not Applicable

Protein
Information

• UniProt
  1 Sequence
• Protein Ontology
  PR:000009489 keratin, type II cytoskeletal 74
  (term hierarchy)
• InterPro Domains
  IPR018039 Intermediate filament protein, conserved site
  IPR039008 Intermediate filament, rod domain
  IPR042180 Intermediate filament, rod domain, coil 1B
  IPR003054 Keratin, type II
  IPR032444 Keratin type II head

Molecular
Reagents

• All nucleic 1

  cDNA 1

References

• Summaries
  All 43

  Developmental Gene Expression 1

  Diseases 1

  Phenotypes 30
• Earliest
  J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
• Latest
  J:236599 Dickinson ME, et al., High-throughput discovery of novel developmental phenotypes. Nature. 2016 Sep 14;537(7621):508-514

TSS for Krt74:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr136610	Chr15:101763557-101763566 (-)	-58 bp