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Krt74 Gene Detail
Summary
  • Symbol
    Krt74
  • Name
    keratin 74
  • Synonyms
    Kb37
Location & Maps
more
  • Sequence Map
    Chr15:101754259-101763504 bp, - strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      9246 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 57.01 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    KRT74, keratin 74
  • Human Ortholog
    KRT74, keratin 74
    Orthology source: HGNC
  • Synonyms
    ADWH, HTSS2, HYPT3, K6IRS4, KRT5C, KRT6IRS4
  • Links
    NCBI Gene ID: 121391
    neXtProt AC: NX_Q7RTS7
    UniProt: Q7RTS7

  • Chr Location
    12q13.13; chr12:52565819-52573825 (-)  GRCh38.p7
  • HCOP
    human homology predictions: KRT74
  • Gene Tree
    Krt74
Human Diseases
more
  • Diseases
    1 with human KRT74 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    29 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    4
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    3
  • Tissues
    3
  • cDNA Data
    1
  • Literature Summary
    1
Interactions
less
Sequences &
Gene Models
less
  • All Sequences
    8
  • RefSeq
    1
  • UniProt
    1
  • UniGene
    359153
Representative SequencesLengthStrain/SpeciesFlank
genomic 406222 NCBI Gene Model | MGI Sequence Detail 9246 C57BL/6J ±  kb
transcript NR_033444 RefSeq | MGI Sequence Detail 1589 Not Specified  
polypeptide Q6IFZ9 UniProt | EBI | MGI Sequence Detail 495 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    97 from dbSNP Build 142
Protein
Information
less
  • UniProt
    1 Sequence
  • InterPro Domains
    IPR001664 Intermediate filament protein
    IPR018039 Intermediate filament protein, conserved site
    IPR039008 Intermediate filament, rod domain
    IPR003054 Keratin, type II
    IPR032444 Keratin type II head
Molecular
Reagents
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  • All nucleic 1
    cDNA 1
References
more
  • Summaries
    All 43
    Developmental Gene Expression 1
    Diseases 1
    Gene Ontology 2
    Phenotypes 29
  • Earliest
    J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
  • Latest
    J:236599 Dickinson ME, et al., High-throughput discovery of novel developmental phenotypes. Nature. 2016 Sep 14;537(7621):508-514
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
10/09/2018
MGI 6.12 		The Jackson Laboratory