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Krt74 Gene Detail
Summary
  • Symbol
    Krt74
  • Name
    keratin 74
  • Synonyms
    Kb37
Location &
Maps
more
  • Sequence Map
    Chr15:101754259-101763504 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 57.01 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    97 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3629975
protein coding gene Chr15:101754259-101763504 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022385
protein coding gene Chr15:103882143-103890411 (-)
A/J MGP_AJ_G0022348
protein coding gene Chr15:99782814-99791201 (-)
AKR/J MGP_AKRJ_G0022323
protein coding gene Chr15:102812956-102821434 (-)
BALB/cJ MGP_BALBcJ_G0022351
protein coding gene Chr15:99855422-99863712 (-)
C3H/HeJ MGP_C3HHeJ_G0022118
protein coding gene Chr15:102891257-102900474 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022800
protein coding gene Chr15:107736443-107744864 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020323
protein coding gene Chr15:95593558-95601637 (-)
CAST/EiJ MGP_CASTEiJ_G0021644
protein coding gene Chr15:103735545-103743734 (-)
CBA/J MGP_CBAJ_G0022087
protein coding gene Chr15:111497477-111508762 (-)
DBA/2J MGP_DBA2J_G0022218
protein coding gene Chr15:99095210-99104250 (-)
FVB/NJ MGP_FVBNJ_G0022194
protein coding gene Chr15:98151520-98160518 (-)
LP/J MGP_LPJ_G0022287
protein coding gene Chr15:104038117-104046373 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022216
protein coding gene Chr15:115127937-115136335 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022812
protein coding gene Chr15:102838337-102846745 (-)
PWK/PhJ MGP_PWKPhJ_G0021384
protein coding gene Chr15:99239301-99247504 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021216
protein coding gene Chr15:102683816-102691919 (-)
WSB/EiJ MGP_WSBEiJ_G0021694
protein coding gene Chr15:103474710-103484344 (-)



Homology
more
  • Human Ortholog
    KRT74, keratin 74
  • Human Ortholog
    KRT74, keratin 74
    Orthology source: HGNC
  • Synonyms
    ADWH, HTSS2, HYPT3, K6IRS4, KRT5C, KRT6IRS4
  • Links
    NCBI Gene ID: 121391
    neXtProt AC: NX_Q7RTS7
    UniProt: Q7RTS7

  • Chr Location
    12q13.13; chr12:52565819-52573825 (-)  GRCh38.p7

  • HCOP
    human homology predictions: KRT74
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human KRT74 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    29 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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  • All Sequences
  • RefSeq
  • UniProt
  • UniGene
Representative SequencesLengthStrain/SpeciesFlank
genomic 406222 NCBI Gene Model | MGI Sequence Detail 9246 C57BL/6J ±  kb
transcript NR_033444 RefSeq | MGI Sequence Detail 1589 Not Specified  
polypeptide Q6IFZ9 UniProt | EBI | MGI Sequence Detail 495 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    1 Sequence
  • InterPro Domains
    IPR001664 Intermediate filament protein
    IPR018039 Intermediate filament protein, conserved site
    IPR039008 Intermediate filament, rod domain
    IPR003054 Keratin, type II
    IPR032444 Keratin type II head
Molecular
Reagents
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  • All nucleic 1
    cDNA 1
References
more
  • Summaries
    All 43
    Developmental Gene Expression 1
    Diseases 1
    Gene Ontology 2
    Phenotypes 29
  • Earliest
    J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
  • Latest
    J:236599 Dickinson ME, et al., High-throughput discovery of novel developmental phenotypes. Nature. 2016 Sep 14;537(7621):508-514

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory