About   Help   FAQ
Clec4a4 Gene Detail
Summary
  • Symbol
    Clec4a4
  • Name
    C-type lectin domain family 4, member a4
  • Synonyms
    Dcir2
  • Feature Type
    protein coding gene
  • IDs
    MGI:3624119
    NCBI Gene: 474145
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:122967326-123001064 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 6, 58.07 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    213 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3624119
protein coding gene Chr6:122967326-123001380 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031238
protein coding gene Chr6:126136412-126164033 (+)
A/J MGP_AJ_G0031207
protein coding gene Chr6:121329768-121357935 (+)
AKR/J MGP_AKRJ_G0031137
protein coding gene Chr6:124688614-124718551 (+)
BALB/cJ MGP_BALBcJ_G0031217
protein coding gene Chr6:121041475-121073522 (+)
C3H/HeJ MGP_C3HHeJ_G0030936
protein coding gene Chr6:124655434-124686006 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031676
protein coding gene Chr6:129445714-129485460 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028832
protein coding gene Chr6:117920247-118044048 (+)
CAST/EiJ MGP_CASTEiJ_G0030325
protein coding gene Chr6:124911090-124928682 (+)
CBA/J MGP_CBAJ_G0030899
protein coding gene Chr6:134494029-134536224 (+)
DBA/2J MGP_DBA2J_G0031055
protein coding gene Chr6:120261533-120295408 (+)
FVB/NJ MGP_FVBNJ_G0031008
protein coding gene Chr6:119200671-119228892 (+)
LP/J MGP_LPJ_G0031136
protein coding gene Chr6:126297897-126328332 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031043
protein coding gene Chr6:138443940-138500087 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031706
protein coding gene Chr6:124582142-124615284 (+)
PWK/PhJ MGP_PWKPhJ_G0030039
protein coding gene Chr6:119096395-119164232 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029867
protein coding gene Chr6:122728068-122855245 (+)
WSB/EiJ MGP_WSBEiJ_G0030407
protein coding gene Chr6:124884141-124912442 (+)



Homology
more
  • Human Ortholog
    CLEC4A, C-type lectin domain family 4 member A
  • Vertebrate Orthologs
    6
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CLEC4A, C-type lectin domain family 4 member A
  • Synonyms
    CD367, CLECSF6, DCIR, DDB27, HDCGC13P, hDCIR, LLIR
  • Links
    NCBI Gene ID: 50856
    neXtProt AC: NX_Q9UMR7
    UniProt: Q9UMR7

  • Chr Location
    12p13.31; chr12:8102907-8138607 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000059639 Ensembl Gene Model | MGI Sequence Detail 33739 C57BL/6J ±  kb
    transcript ENSMUST00000079379 Ensembl | MGI Sequence Detail 776 Not Applicable  
    polypeptide ENSMUSP00000078351 Ensembl | MGI Sequence Detail 236 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 3
      cDNA 3

      Microarray probesets 1
    References
    more
    • Summaries
      All 26
      Developmental Gene Expression 1
      Gene Ontology 3
      Phenotypes 9
    • Earliest
      J:93065 Flornes LM, et al., Identification of lectin-like receptors expressed by antigen presenting cells and neutrophils and their mapping to a novel gene complex. Immunogenetics. 2004 Oct;56(7):506-17
    • Latest
      J:344872 Bellini R, et al., Dendritic cell immunoreceptor 2 (DCIR2) deficiency decreases hepatic conventional dendritic cell content but not the progression of diet-induced obesity. Immun Inflamm Dis. 2023 Oct;11(10):e1024

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.
    last database update
    03/19/2024
    MGI 6.23
    The Jackson Laboratory