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Mir425 Gene Detail
Summary
  • Symbol
    Mir425
  • Name
    microRNA 425
  • Synonyms
    mir 425, Mirn425, mmu-mir-425
  • Feature Type
    miRNA gene
  • IDs
    MGI:3619401
    NCBI Gene: 723864
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr9:108568777-108568861 bp, + strand
  • From miRBase annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 59.51 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    12 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3619401
miRNA gene Chr9:108568777-108568861 (+)
129S1/SvImJ MGP_129S1SvImJ_G0009237
miRNA gene Chr9:110536143-110536227 (+)
A/J MGP_AJ_G0009218
miRNA gene Chr9:106485010-106485094 (+)
AKR/J MGP_AKRJ_G0009207
miRNA gene Chr9:109154104-109154188 (+)
BALB/cJ MGP_BALBcJ_G0009202
miRNA gene Chr9:106180474-106180558 (+)
C3H/HeJ MGP_C3HHeJ_G0009143
miRNA gene Chr9:109555452-109555536 (+)
C57BL/6NJ MGP_C57BL6NJ_G0009444
miRNA gene Chr9:113550826-113550910 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0008298
miRNA gene Chr9:103913145-103913229 (+)
CAST/EiJ MGP_CASTEiJ_G0008973
miRNA gene Chr9:109513428-109513512 (+)
CBA/J MGP_CBAJ_G0009108
miRNA gene Chr9:117557025-117557109 (+)
DBA/2J MGP_DBA2J_G0009138
miRNA gene Chr9:105943975-105944059 (+)
FVB/NJ MGP_FVBNJ_G0009156
miRNA gene Chr9:104705642-104705726 (+)
LP/J MGP_LPJ_G0009235
miRNA gene Chr9:110730693-110730777 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0009122
miRNA gene Chr9:119129127-119129211 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0009414
miRNA gene Chr9:109432899-109432983 (+)
PWK/PhJ MGP_PWKPhJ_G0008898
miRNA gene Chr9:106269412-106269496 (+)
SPRET/EiJ MGP_SPRETEiJ_G0008737
miRNA gene Chr9:109495649-109495733 (+)
WSB/EiJ MGP_WSBEiJ_G0009067
miRNA gene Chr9:109314633-109314717 (+)



Homology
more
  • Human Ortholog
    MIR425, microRNA 425
  • Human Ortholog
    MIR425, microRNA 425
    Orthology source: HGNC
  • Synonyms
    hsa-mir-425, mir-425, MIRN425
  • Links
    NCBI Gene ID: 494337

  • Chr Location
    chr3:49020148-49020234 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    1 phenotype reference
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice heterozygous for a null allele exhibit increased dopaminergic neuron loss and aggravated MPTP-induced motor deficits and dopaminergic neurodegeneration.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    • All Sequences
    • RefSeq
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 723864 NCBI Gene Model | MGI Sequence Detail 85 C57BL/6J ±  kb
    transcript NR_029947 RefSeq | MGI Sequence Detail 85 C57BL/6  
    For the selected sequence
    Molecular
    Reagents
    less
    • All nucleic 2
      Other 2
    Other Database
    Links
    less
    References
    more
    • Summaries
      All 13
      Developmental Gene Expression 2
      Gene Ontology 3
      Phenotypes 1
    • Earliest
      J:105741 Griffiths-Jones S, et al., miRBase: microRNA sequences, targets and gene nomenclature. Nucleic Acids Res. 2006 Jan 1;34(Database issue):D140-4
    • Latest
      J:280159 Hu YB, et al., miR-425 deficiency promotes necroptosis and dopaminergic neurodegeneration in Parkinson's disease. Cell Death Dis. 2019 Aug 5;10(8):589

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    last database update
    01/14/2020
    MGI 6.14
    The Jackson Laboratory