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Mir375 Gene Detail
Summary
  • Symbol
    Mir375
  • Name
    microRNA 375
  • Synonyms
    mir 375, Mirn375, mmu-mir-375
  • Feature Type
    miRNA gene
  • IDs
    MGI:3619376
    NCBI Gene: 723900
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr1:74900658-74900721 bp, - strand
  • From miRBase annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 38.54 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    21 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3619376
miRNA gene Chr1:74900658-74900721 (-)
129S1/SvImJ MGP_129S1SvImJ_G0007631
miRNA gene Chr1:75514078-75514141 (-)
A/J MGP_AJ_G0007626
miRNA gene Chr1:72884518-72884581 (-)
AKR/J MGP_AKRJ_G0007600
miRNA gene Chr1:74899745-74899808 (-)
BALB/cJ MGP_BALBcJ_G0007603
miRNA gene Chr1:72944576-72944639 (-)
C3H/HeJ MGP_C3HHeJ_G0007549
miRNA gene Chr1:75242681-75242744 (-)
C57BL/6NJ MGP_C57BL6NJ_G0007778
miRNA gene Chr1:78458396-78458459 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0006948
miRNA gene Chr1:68446595-68446658 (-)
CAST/EiJ MGP_CASTEiJ_G0007448
miRNA gene Chr1:74567458-74567521 (-)
CBA/J MGP_CBAJ_G0007524
miRNA gene Chr1:81014771-81014834 (-)
DBA/2J MGP_DBA2J_G0007558
miRNA gene Chr1:72201326-72201389 (-)
FVB/NJ MGP_FVBNJ_G0007572
miRNA gene Chr1:71399620-71399683 (-)
LP/J MGP_LPJ_G0007637
miRNA gene Chr1:76635987-76636050 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0007546
miRNA gene Chr1:84389608-84389671 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0007778
miRNA gene Chr1:74973266-74973329 (-)
PWK/PhJ MGP_PWKPhJ_G0007381
miRNA gene Chr1:71665336-71665399 (-)
SPRET/EiJ MGP_SPRETEiJ_G0007284
miRNA gene Chr1:74338523-74338586 (-)
WSB/EiJ MGP_WSBEiJ_G0007513
miRNA gene Chr1:74791172-74791235 (-)



Homology
more
  • Human Ortholog
    MIR375, microRNA 375
  • Human Ortholog
    MIR375, microRNA 375
    Orthology source: HGNC
  • Synonyms
    hsa-mir-375, mir-375, MIRN375, miRNA375
  • Links
    NCBI Gene ID: 494324

  • Chr Location
    chr2:219001645-219001708 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 1 allele in 1 genetic background
    9 phenotypes from multigenic genotypes
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display hyperglycemia, hyperglucagonemia, decreased beta cell numnber and mass, increased alpha cell number, increased insulin and glucagon secretion, and enhanced gluconeogenesis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    • All Sequences
    • RefSeq
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 723900 NCBI Gene Model | MGI Sequence Detail 64 C57BL/6J ±  kb
    transcript NR_029876 RefSeq | MGI Sequence Detail 64 C57BL/6  
    For the selected sequence
    Molecular
    Reagents
    less
    • All nucleic 1
      Other 1
    Other Database
    Links
    less
    References
    more
    • Summaries
      All 32
      Developmental Gene Expression 9
      Gene Ontology 1
      Phenotypes 11
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:247144 Sun T, et al., miR-375-3p negatively regulates osteogenesis by targeting and decreasing the expression levels of LRP5 and beta-catenin. PLoS One. 2017;12(2):e0171281

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    last database update
    11/10/2020
    MGI 6.16
    The Jackson Laboratory