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Mir218-2 Gene Detail
Summary
  • Symbol
    Mir218-2
  • Name
    microRNA 218-2
  • Synonyms
    mir 218-2, mir-218-2, Mirn218-2, mmu-mir-218-2
  • Feature Type
    miRNA gene
  • IDs
    MGI:3618752
    NCBI Gene: 723924
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr11:35507643-35507752 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 21.71 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    46 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3618752
 miRNA gene Chr11:35507643-35507752 (+)
129S1/SvImJ MGP_129S1SvImJ_G0007793
 miRNA gene Chr11:34012148-34012257 (+)
A/J MGP_AJ_G0007789
 miRNA gene Chr11:32741349-32741458 (+)
AKR/J MGP_AKRJ_G0007763
 miRNA gene Chr11:33728850-33728959 (+)
BALB/cJ MGP_BALBcJ_G0007766
 miRNA gene Chr11:32905263-32905372 (+)
C3H/HeJ MGP_C3HHeJ_G0007713
 miRNA gene Chr11:33676160-33676269 (+)
C57BL/6NJ MGP_C57BL6NJ_G0007944
 miRNA gene Chr11:35044706-35044815 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0007091
 miRNA gene Chr11:31199412-31199521 (+)
CAST/EiJ MGP_CASTEiJ_G0007607
 miRNA gene Chr11:33662860-33662969 (+)
CBA/J MGP_CBAJ_G0007685
 miRNA gene Chr11:36739606-36739715 (+)
DBA/2J MGP_DBA2J_G0007720
 miRNA gene Chr11:32485851-32485960 (+)
FVB/NJ MGP_FVBNJ_G0007737
 miRNA gene Chr11:32334942-32335051 (+)
LP/J MGP_LPJ_G0007797
 miRNA gene Chr11:34226802-34226911 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0007707
 miRNA gene Chr11:37461522-37461631 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0007942
 miRNA gene Chr11:33745930-33746039 (+)
PWK/PhJ MGP_PWKPhJ_G0007537
 miRNA gene Chr11:32570449-32570558 (+)
SPRET/EiJ MGP_SPRETEiJ_G0007433
 miRNA gene Chr11:33522162-33522271 (+)
WSB/EiJ MGP_WSBEiJ_G0007674
 miRNA gene Chr11:33522608-33522717 (+)



Homology
more
  • Human Ortholog
    MIR218-2, microRNA 218-2
  • Vertebrate Orthologs
    1
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MIR218-2, microRNA 218-2
  • Synonyms
    mir-218-2, MIRN218-2
  • Links
    NCBI Gene ID: 407001

  • Chr Location
    chr5:168768146-168768255 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from multigenic genotypes
    6 phenotype references
  • All Mutations and Alleles
    3
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    1
  • Targeted
    1
  • Genomic Mutations
    1 involving Mir218-2
  • Find Mice (IMSR)
    1 strains or lines available
Mice null for both Mir218-1 and Mir218-2 display neonatal lethality with a systemic neuromuscular failure.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    6
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    859
  • Tissues
    47
  • Literature Summary
    15
Sequences &
Gene Models
less
  • All Sequences
    23
  • RefSeq
    1
Representative SequencesLengthStrain/SpeciesFlank
genomic 723924 NCBI Gene Model | MGI Sequence Detail 110 C57BL/6J ±  kb
transcript NR_029799 RefSeq | MGI Sequence Detail 110 C57BL/6  
For the selected sequence
Molecular
Reagents
less
  • All nucleic 6
    Primer pair 2
    Other 4
Other Database
Links
less
miRBase MI0000701
References
more
  • Summaries
    All 29
    Developmental Gene Expression 15
    Gene Ontology 2
    Phenotypes 6
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:333210 Jiang T, et al., MicroRNA-218 regulates neuronal radial migration and morphogenesis by targeting Satb2 in developing neocortex. Biochem Biophys Res Commun. 2023 Mar 5;647:9-15
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory