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Mir1a-2 Gene Detail
Summary
  • Symbol
    Mir1a-2
  • Name
    microRNA 1a-2
  • Synonyms
    mir 1-2, Mirn1-2, mmu-mir-1-2, mmu-mir-1a-2
Location &
Maps
more
  • Sequence Map
    Chr18:10785481-10785552 bp, - strand
  • From miRBase annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 5.40 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    9 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3618746
miRNA gene Chr18:10785481-10785552 (-)
129S1/SvImJ MGP_129S1SvImJ_G0008369
miRNA gene Chr18:7728051-7728122 (-)
A/J MGP_AJ_G0008358
miRNA gene Chr18:7675944-7676015 (-)
AKR/J MGP_AKRJ_G0008342
miRNA gene Chr18:7877769-7877840 (-)
BALB/cJ MGP_BALBcJ_G0008342
miRNA gene Chr18:7660374-7660445 (-)
C3H/HeJ MGP_C3HHeJ_G0008287
miRNA gene Chr18:7770883-7770954 (-)
C57BL/6NJ MGP_C57BL6NJ_G0008541
miRNA gene Chr18:8182426-8182497 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0007582
miRNA gene Chr18:7353022-7353093 (-)
CAST/EiJ MGP_CASTEiJ_G0008151
miRNA gene Chr18:7666929-7667000 (-)
CBA/J MGP_CBAJ_G0008254
miRNA gene Chr18:8243421-8243492 (-)
DBA/2J MGP_DBA2J_G0008285
miRNA gene Chr18:7543787-7543858 (-)
FVB/NJ MGP_FVBNJ_G0008309
miRNA gene Chr18:7491450-7491521 (-)
LP/J MGP_LPJ_G0008371
miRNA gene Chr18:7855240-7855311 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0008273
miRNA gene Chr18:8489085-8489156 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0008530
miRNA gene Chr18:7708969-7709040 (-)
PWK/PhJ MGP_PWKPhJ_G0008071
miRNA gene Chr18:7576767-7576838 (-)
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0008232
miRNA gene Chr18:7683746-7683817 (-)



Homology
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Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    15 phenotypes from 1 allele in 1 genetic background
    18 phenotypes from multigenic genotypes
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice show pericardial edema and impaired cardiac morphogenesis and electrophysiology, including ventricular septal defects in a subset that suffer early lethality, and reduced heart rate and cell cycle defects leading to hyperplasia in surviving adults. About 50% die by weaning.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    • All Sequences
    • RefSeq
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 723959 NCBI Gene Model | MGI Sequence Detail 72 C57BL/6J ±  kb
    transcript NR_029781 RefSeq | MGI Sequence Detail 72 C57BL/6  
    For the selected sequence
    Molecular
    Reagents
    less
    • All nucleic 5
      Primer pair 2
      Other 3
    Other Database
    Links
    less
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 25
      Gene Ontology 5
      Phenotypes 4
    • Earliest
      J:93952 Mansfield JH, et al., MicroRNA-responsive 'sensor' transgenes uncover Hox-like and other developmentally regulated patterns of vertebrate microRNA expression. Nat Genet. 2004 Oct;36(10):1079-83
    • Latest
      J:242463 Wei Y, et al., Multifaceted roles of miR-1s in repressing the fetal gene program in the heart. Cell Res. 2014 Mar;24(3):278-92

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory