About   Help   FAQ
Mir1a-2 Gene Detail
Summary
  • Symbol
    Mir1a-2
  • Name
    microRNA 1a-2
  • Synonyms
    mir 1-2, Mirn1-2, mmu-mir-1-2, mmu-mir-1a-2
  • Feature Type
    miRNA gene
  • IDs
    MGI:3618746
    NCBI Gene: 723959
  • Member of
    Mirc18 cluster
Location & Maps
more
  • Sequence Map
    Chr18:10785481-10785552 bp, - strand
  • From miRBase annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      72 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 5.40 cM
  • Mapping Data
    1 experiment
Homology
less
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 1 allele in 1 genetic background
    18 phenotypes from multigenic genotypes
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    2
  • Targeted
    2
  • Genomic Mutations
    1 involving Mir1a-2
Homozygous null mice show pericardial edema and impaired cardiac morphogenesis and electrophysiology, including ventricular septal defects in a subset that suffer early lethality, and reduced heart rate and cell cycle defects leading to hyperplasia in surviving adults. About 50% die by weaning.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • Literature Summary
  • Other Mouse Links
Interactions
less
Sequences &
Gene Models
less
  • All Sequences
  • RefSeq
Representative SequencesLengthStrain/SpeciesFlank
genomic 723959 NCBI Gene Model | MGI Sequence Detail 72 C57BL/6J ±  kb
transcript NR_029781 RefSeq | MGI Sequence Detail 72 C57BL/6  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    9 from dbSNP Build 142
Molecular
Reagents
less
  • All nucleic 4
    Primer pair 1
    Other 3
Other Database
Links
less
References
more
  • Summaries
    All 44
    Developmental Gene Expression 25
    Gene Ontology 5
    Phenotypes 3
  • Earliest
    J:93952 Mansfield JH, et al., MicroRNA-responsive 'sensor' transgenes uncover Hox-like and other developmentally regulated patterns of vertebrate microRNA expression. Nat Genet. 2004 Oct;36(10):1079-83
  • Latest
    J:230021 Peng Y, et al., Critical roles of miRNA-mediated regulation of TGFbeta signalling during mouse cardiogenesis. Cardiovasc Res. 2014 Jul 15;103(2):258-67

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/27/2016
MGI 6.05
The Jackson Laboratory