Aoc1l1 MGI Mouse Gene Detail - MGI:3618290 - amine oxidase copper containing 1-like 1

Symbol

Aoc1l1
Name

amine oxidase copper containing 1-like 1
Synonyms

Doxl2

Feature Type

protein coding gene
IDs

MGI:3618290
NCBI Gene: 243376
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr6:48951897-48955680 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 23.82 cM
Mapping Data

1 experiment

SNPs within 2kb

31 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3618290	protein coding gene	Chr6:48951880-48955680 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0030717	protein coding gene	Chr6:47957693-47961476 (+)
A/J	MGP_AJ_G0030688	protein coding gene	Chr6:45767817-45771601 (+)
AKR/J	MGP_AKRJ_G0030613	protein coding gene	Chr6:47383225-47387008 (+)
BALB/cJ	MGP_BALBcJ_G0030698	protein coding gene	Chr6:46108771-46112554 (+)
C3H/HeJ	MGP_C3HHeJ_G0030411	protein coding gene	Chr6:47384103-47387886 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0031153	protein coding gene	Chr6:49086652-49090435 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028360	protein coding gene	Chr6:43380930-43384701 (+)
CAST/EiJ	MGP_CASTEiJ_G0029815	protein coding gene	Chr6:47113789-47117585 (+)
CBA/J	MGP_CBAJ_G0030386	protein coding gene	Chr6:51122560-51126343 (+)
DBA/2J	MGP_DBA2J_G0030535	protein coding gene	Chr6:45683957-45687740 (+)
FVB/NJ	MGP_FVBNJ_G0030487	protein coding gene	Chr6:45318276-45322059 (+)
LP/J	MGP_LPJ_G0030620	protein coding gene	Chr6:47938357-47942140 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0030521	protein coding gene	Chr6:53899187-53902971 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031182	protein coding gene	Chr6:47243654-47247437 (+)
PWK/PhJ	MGP_PWKPhJ_G0029527	protein coding gene	Chr6:45225141-45228983 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0029363	protein coding gene	Chr6:46591490-46595292 (+)
WSB/EiJ	MGP_WSBEiJ_G0029892	protein coding gene	Chr6:47247740-47252188 (+)

Human Ortholog

AOC1, amine oxidase copper containing 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

AOC1, amine oxidase copper containing 1
Synonyms

ABP, ABP1, DAO, DAO1, KAO
Links

HGNC:80

NCBI Gene ID: 26

neXtProt AC: NX_P19801

UniProt: P19801
Chr Location

7q36.1; chr7:150824627-150861504 (+) GRCh38

MGI Vertebrate Homology

Aoc1l1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: AOC1
Gene Tree

Aoc1l1

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Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
5 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

3
Endonuclease-mediated

1
Targeted

2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

48 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

17
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

712
Tissues

4
cDNA Data

15
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

34
RefSeq

3
UniProt

4
CCDS

CCDS20120.1

Ensembl

ENSMUSG00000068536 (Evidence)
NCBI Gene

243376

			Length	Strain/Species	Flank
genomic	ENSMUSG00000068536	Ensembl Gene Model \| MGI Sequence Detail	3784	C57BL/6J	± kb
transcript	ENSMUST00000184917	Ensembl \| MGI Sequence Detail	2468	Not Applicable
polypeptide	ENSMUSP00000139012	Ensembl \| MGI Sequence Detail	723	Not Applicable

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UniProt

4 Sequences
EC

1.4.3.-
InterPro Domains

IPR000269 Copper amine oxidase

IPR015798 Copper amine oxidase, catalytic domain

IPR036460 Copper amine oxidase, catalytic domain superfamily

IPR015800 Copper amine oxidase, N2-terminal

IPR015802 Copper amine oxidase, N3-terminal

IPR016182 Copper amine oxidase, N-terminal

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All nucleic 15

cDNA 15

Microarray probesets 1

Summaries

All 19

Developmental Gene Expression 1

Gene Ontology 2

Phenotypes 5
Earliest

J:86672 Lundwall A, et al., Molecular cloning of complementary DNA encoding mouse seminal vesicle-secreted protein SVS I and demonstration of homology with copper amine oxidases. Biol Reprod. 2003 Dec;69(6):1923-30
Latest

J:228563 Koscielny G, et al., The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Nucleic Acids Res. 2014 Jan;42(Database issue):D802-9

TSS for Aoc1l1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr56259	Chr6:48951867-48951894 (+)	-16 bp
Tssr56260	Chr6:48954076-48954082 (+)	2,182 bp
Tssr56261	Chr6:48954092-48954097 (+)	2,198 bp
Tssr56262	Chr6:48954165-48954208 (+)	2,290 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23