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Wfdc10 Gene Detail
Summary
  • Symbol
    Wfdc10
  • Name
    WAP four-disulfide core domain 10
  • Synonyms
    OTTMUSG00000016289
  • Feature Type
    protein coding gene
  • IDs
    MGI:3616889
    NCBI Gene: 629756
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:164497966-164499288 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 85.24 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    42 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3616889
protein coding gene Chr2:164497966-164499288 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026864
protein coding gene Chr2:170137367-170138689 (+)
A/J MGP_AJ_G0026831
protein coding gene Chr2:163191055-163192377 (+)
AKR/J MGP_AKRJ_G0026802
protein coding gene Chr2:168040761-168042083 (+)
BALB/cJ MGP_BALBcJ_G0026840
protein coding gene Chr2:163551486-163552808 (+)
C3H/HeJ MGP_C3HHeJ_G0026582
protein coding gene Chr2:168401604-168402927 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027287
protein coding gene Chr2:175067239-175068561 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024658
protein coding gene Chr2:156602157-156603456 (+)
CAST/EiJ MGP_CASTEiJ_G0026040
protein coding gene Chr2:168819001-168820324 (+)
CBA/J MGP_CBAJ_G0026559
protein coding gene Chr2:181420577-181421899 (+)
DBA/2J MGP_DBA2J_G0026697
protein coding gene Chr2:162358648-162359971 (+)
FVB/NJ MGP_FVBNJ_G0026663
protein coding gene Chr2:160778584-160779907 (+)
LP/J MGP_LPJ_G0026799
protein coding gene Chr2:170208506-170209828 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026682
protein coding gene Chr2:184976921-184978243 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027344
protein coding gene Chr2:167943503-167944826 (+)
PWK/PhJ MGP_PWKPhJ_G0025777
protein coding gene Chr2:161957598-161958891 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025578
protein coding gene Chr2:166850260-166851578 (+)
WSB/EiJ MGP_WSBEiJ_G0026113
protein coding gene Chr2:168826462-168827784 (+)



Homology
more
  • Human Ortholog
    WFDC10A, WAP four-disulfide core domain 10A
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    WFDC10A, WAP four-disulfide core domain 10A
  • Synonyms
    C20orf146, dJ688G8.3, WAP10
  • Links
    NCBI Gene ID: 140832
    neXtProt AC: NX_Q9H1F0
    UniProt: Q9H1F0

  • Chr Location
    20q13.12; chr20:45629746-45631192 (+)  GRCh38.p7

  • Human Ortholog
    WFDC10B, WAP four-disulfide core domain 10B
  • Synonyms
    WAP12
  • Links
    NCBI Gene ID: 280664
    neXtProt AC: NX_Q8IUB3
    UniProt: Q8IUB3

  • Chr Location
    20q13.12; chr20:45684651-45708899 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype reference
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • cDNA Data
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 629756 NCBI Gene Model | MGI Sequence Detail 1323 C57BL/6J ±  kb
transcript NM_001039501 RefSeq | MGI Sequence Detail 459 C57BL/6  
polypeptide NP_001034590 RefSeq | MGI Sequence Detail 124 C57BL/6  
For the selected sequence
Protein
Information
less
  • UniProt
    2 Sequences
  • InterPro Domains
    IPR029721 WAP four-disulfide core domain protein 10A
    IPR008197 WAP-type 'four-disulfide core' domain
Molecular
Reagents
less
  • All nucleic 6
    cDNA 6

    Microarray probesets 1
Other
Accession IDs
less
MGI:3652264
References
more
  • Summaries
    All 15
    Gene Ontology 1
    Phenotypes 1
  • Earliest
    J:112572 Jalkanen J, et al., Novel epididymal protease inhibitors with Kazal or WAP family domain. Biochem Biophys Res Commun. 2006 Oct 13;349(1):245-54
  • Latest
    J:300068 Andrade AD, et al., Lipopolysaccharide-induced epididymitis modifies the transcriptional profile of Wfdc genes in mice. Biol Reprod. 2021 Jan 4;104(1):144-158

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
09/22/2022
MGI 6.21
The Jackson Laboratory