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Tagap Gene Detail
Summary
  • Symbol
    Tagap
  • Name
    T cell activation Rho GTPase activating protein
  • Feature Type
    protein coding gene
  • IDs
    MGI:3615484
    NCBI Gene: 72536
Location & Maps
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Homology
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  • Human Ortholog
    TAGAP, T-cell activation RhoGTPase activating protein
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TAGAP, T-cell activation RhoGTPase activating protein
    Orthology source: HomoloGene
  • Synonyms
    ARHGAP47, FKSG15, IDDM21, TAGAP1
  • Links
    NCBI Gene ID: 117289
    neXtProt AC: NX_Q8N103

  • Chr Location
    6q25.3; chr6:159034468-159045152 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 44943
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: TAGAP
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from multigenic genotypes
    4 phenotype references
  • All Mutations and Alleles
    2
  • Targeted
    2
  • Incidental Mutations
    APF , CvDC
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034757 VEGA Gene Model | MGI Sequence Detail 8898 C57BL/6J ±  kb
transcript OTTMUST00000088332 VEGA | MGI Sequence Detail 3076 Not Applicable  
polypeptide OTTMUSP00000048122 VEGA | MGI Sequence Detail 714 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    55 from dbSNP Build 142
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000016038 T-cell activation Rho GTPase-activating protein
  • InterPro Domains
    IPR000198 Rho GTPase-activating protein domain
    IPR008936 Rho GTPase activation protein
Molecular
Reagents
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  • All nucleic 3
    cDNA 3

    Microarray probesets 2
References
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  • Summaries
    All 20
    Gene Ontology 2
    Phenotypes 4
  • Earliest
    J:100859 Bauer H, et al., The t complex-encoded GTPase-activating protein Tagap1 acts as a transmission ratio distorter in mice. Nat Genet. 2005 Sep;37(9):969-73
  • Latest
    J:222462 Liao J, et al., An image-based genetic assay identifies genes in T1D susceptibility loci controlling cellular antiviral immunity in mouse. PLoS One. 2014;9(9):e108777

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory