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Tagap Gene Detail
Summary
  • Symbol
    Tagap
  • Name
    T cell activation Rho GTPase activating protein
  • Synonyms
    Tcd1, Tcd-1, Tcd1a, tcs1, tcs-1, TRD
  • Feature Type
    protein coding gene
  • IDs
    MGI:3615484
    NCBI Gene: 72536
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:7926000-7934897 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 4.82 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    55 from dbSNP Build 142
  • Strain Annotations
    15
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3615484
protein coding gene Chr17:7926000-7934897 (.)
129S1/SvImJ MGP_129S1SvImJ_G0023121
protein coding gene Chr17:5185750-5238253 (+)
A/J MGP_AJ_G0023095
protein coding gene Chr17:5431374-5440675 (+)
AKR/J no annotation
BALB/cJ no annotation
C3H/HeJ MGP_C3HHeJ_G0022856
protein coding gene Chr17:5327002-5337883 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023536
protein coding gene Chr17:5446352-5456022 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021037
protein coding gene Chr17:3471875-3480813 (-)
CAST/EiJ MGP_CASTEiJ_G0022367
protein coding gene Chr17:5139795-5149010 (+)
CBA/J MGP_CBAJ_G0022826
protein coding gene Chr17:5793682-5805218 (+)
DBA/2J no annotation
FVB/NJ MGP_FVBNJ_G0022932
protein coding gene Chr17:5007051-5021235 (+)
LP/J MGP_LPJ_G0023024
protein coding gene Chr17:4289307-4299291 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022951
protein coding gene Chr17:5571332-5581414 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023561
protein coding gene Chr17:5307709-5361481 (+)
PWK/PhJ MGP_PWKPhJ_G0022116
protein coding gene Chr17:4675632-4689630 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021941
protein coding gene Chr17:3922366-3931284 (-)
WSB/EiJ MGP_WSBEiJ_G0022423
protein coding gene Chr17:5389668-5399200 (+)



Homology
more
  • Human Ortholog
    TAGAP, T cell activation RhoGTPase activating protein
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TAGAP, T cell activation RhoGTPase activating protein
    Orthology source: HomoloGene
  • Synonyms
    ARHGAP47, FKSG15, IDDM21, TAGAP1
  • Links
    NCBI Gene ID: 117289
    neXtProt AC: NX_Q8N103
    UniProt: Q8N103

  • Chr Location
    6q25.3; chr6:159034468-159045152 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 44943
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: TAGAP
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from multigenic genotypes
    4 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 72536 NCBI Gene Model | MGI Sequence Detail 8898 C57BL/6J ±  kb
transcript NM_145968 RefSeq | MGI Sequence Detail 3076 Not Specified  
polypeptide B2RWW0 UniProt | EBI | MGI Sequence Detail 714 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
  • InterPro Domains
    IPR000198 Rho GTPase-activating protein domain
    IPR008936 Rho GTPase activation protein
Molecular
Reagents
less
  • All nucleic 4
    cDNA 4

    Microarray probesets 2
Other
Accession IDs
less
MGD-MRK-14737, MGD-MRK-14742, MGD-MRK-14931, MGD-MRK-14934, MGI:98499
References
more
  • Summaries
    All 31
    Gene Ontology 5
    Phenotypes 4
  • Earliest
    J:6915 Klein J, et al., H-2 haplotypes, genes, and antigens: second listing. I. Non-H-2 loci on chromosome 17. Immunogenetics. 1982;16(4):285-317
  • Latest
    J:222462 Liao J, et al., An image-based genetic assay identifies genes in T1D susceptibility loci controlling cellular antiviral immunity in mouse. PLoS One. 2014;9(9):e108777

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory