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Klk13 Gene Detail
Summary
  • Symbol
    Klk13
  • Name
    kallikrein related-peptidase 13
  • Synonyms
    mGk-13
  • Feature Type
    protein coding gene
  • IDs
    MGI:3615275
    NCBI Gene: 626834
  • Alliance
    genome feature page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:43361991-43376958 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 28.26 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    351 from dbSNP Build 142
  • Strain Annotations
    27
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3615275
 protein coding gene Chr7:43361991-43377288 (+)
129S1/SvImJ ENSMUSG00200028756
 protein coding gene Chr7:30948740-30956653 (+)
129S1/SvImJ ENSMUSGG00200054432
 protein coding gene Chr7:30956610-30959209 (+)
A/J ENSMUSG00195047811
 protein coding gene Chr7:34988902-34996826 (+)
A/J ENSMUSGG00195054928
 protein coding gene Chr7:34996783-34999382 (+)
AKR/J ENSMUSGG00220054966
 protein coding gene Chr7:29294852-29297451 (+)
AKR/J ENSMUSG00220043749
 protein coding gene Chr7:29286982-29294895 (+)
BALB/cJ ENSMUSGG00180055573
 protein coding gene Chr7:31872281-31874880 (+)
BALB/cJ ENSMUSG00180038035
 protein coding gene Chr7:31864397-31872324 (+)
C3H/HeJ ENSMUSGG00175054612
 protein coding gene Chr7:32392550-32395149 (+)
C3H/HeJ ENSMUSG00175038621
 protein coding gene Chr7:32384683-32392593 (+)
C57BL/6NJ ENSMUSGG00215055761
 protein coding gene Chr7:31662377-31664976 (+)
C57BL/6NJ ENSMUSG00215043968
 protein coding gene Chr7:31654507-31662420 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029635
 protein coding gene Chr7:44972148-44987499 (+)
CAST/EiJ no annotation
CBA/J ENSMUSGG00210055069
 protein coding gene Chr7:32769292-32771891 (+)
CBA/J ENSMUSG00210046472
 protein coding gene Chr7:32761423-32769335 (+)
DBA/2J ENSMUSGG00185057906
 protein coding gene Chr7:36642301-36644890 (+)
DBA/2J ENSMUSG00185037987
 protein coding gene Chr7:36634324-36642344 (+)
FVB/NJ ENSMUSGG00205054623
 protein coding gene Chr7:32314505-32317104 (+)
FVB/NJ ENSMUSG00205046105
 protein coding gene Chr7:32306636-32314548 (+)
JF1/MsJ no annotation
LP/J ENSMUSGG00230055863
 protein coding gene Chr7:42077811-42080411 (+)
LP/J ENSMUSG00230049970
 protein coding gene Chr7:42069937-42077854 (+)
NOD/ShiLtJ ENSMUSGG00190055082
 protein coding gene Chr7:32636203-32638802 (+)
NOD/ShiLtJ ENSMUSG00190048167
 protein coding gene Chr7:32628335-32636246 (+)
NZO/HlLtJ ENSMUSG00225016747
 protein coding gene Chr7:40280599-40288511 (+)
NZO/HlLtJ ENSMUSGG00225055566
 protein coding gene Chr7:40288468-40291067 (+)
PWK/PhJ no annotation
SPRET/EiJ ENSMSPG00010028074
 protein coding gene Chr7:31342548-31357645 (+)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    KLK13, kallikrein related peptidase 13
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KLK13, kallikrein related peptidase 13
  • Synonyms
    KLK-L4, KLKL4
  • Links
    NCBI Gene ID: 26085
    UniProt: Q9UKR3

  • Chr Location
    19q13.41; chr19:51055626-51065679 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    601
  • Tissues
    1
  • cDNA Data
    2
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000054046 Ensembl Gene Model | MGI Sequence Detail 14968 C57BL/6J ±  kb
    transcript ENSMUST00000066834 Ensembl | MGI Sequence Detail 1809 Not Applicable  
    polypeptide ENSMUSP00000065308 Ensembl | MGI Sequence Detail 276 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • EC
      3.4.21.1
    • InterPro Domains
      IPR001314 Peptidase S1A, chymotrypsin family
      IPR009003 Peptidase S1, PA clan
      IPR018114 Serine protease-like, trypsin family, histidine active site
      IPR001254 Serine proteases, trypsin domain
      IPR033116 Serine proteases, trypsin family, serine active site
    Molecular
    Reagents
    less
    • All nucleic 2
      cDNA 2

      Microarray probesets 1
    References
    more
    • Summaries
      All 35
      Developmental Gene Expression 1
      Gene Ontology 8
      Phenotypes 6
    • Earliest
      J:8756 Evans BA, et al., Mouse glandular kallikrein genes. Structure and partial sequence analysis of the kallikrein gene locus. J Biol Chem. 1987 Jun 15;262(17):8027-34
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory