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Ripply1 Gene Detail
Summary
  • Symbol
    Ripply1
  • Name
    ripply transcriptional repressor 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:3614797
    NCBI Gene: 622473
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:139779681-139782353 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome X, 61.35 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    33 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3614797
protein coding gene ChrX:139779549-139782353 (-)
129S1/SvImJ MGP_129S1SvImJ_G0036127
protein coding gene ChrX:137293274-137296078 (-)
A/J MGP_AJ_G0036105
protein coding gene ChrX:136669237-136672323 (-)
AKR/J MGP_AKRJ_G0036030
protein coding gene ChrX:141065683-141068475 (-)
BALB/cJ MGP_BALBcJ_G0036095
protein coding gene ChrX:135020800-135023598 (-)
C3H/HeJ MGP_C3HHeJ_G0035804
protein coding gene ChrX:137327592-137330396 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036620
protein coding gene ChrX:141329189-141331993 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033444
protein coding gene ChrX:128428137-128430871 (-)
CAST/EiJ MGP_CASTEiJ_G0035095
protein coding gene ChrX:118127764-118130561 (-)
CBA/J MGP_CBAJ_G0035781
protein coding gene ChrX:145654388-145657166 (-)
DBA/2J MGP_DBA2J_G0035938
protein coding gene ChrX:135847807-135850599 (-)
FVB/NJ MGP_FVBNJ_G0035872
protein coding gene ChrX:135080835-135083649 (-)
LP/J MGP_LPJ_G0036029
protein coding gene ChrX:138265240-138268187 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035909
protein coding gene ChrX:153178426-153181212 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036656
protein coding gene ChrX:136604924-136607716 (-)
PWK/PhJ MGP_PWKPhJ_G0034788
protein coding gene ChrX:115051235-115054013 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034614
protein coding gene ChrX:118662579-118665333 (-)
WSB/EiJ MGP_WSBEiJ_G0035230
protein coding gene ChrX:134931088-134934193 (-)



Homology
more
  • Human Ortholog
    RIPPLY1, ripply transcriptional repressor 1
  • Vertebrate Orthologs
    3
  • Human Ortholog
    RIPPLY1, ripply transcriptional repressor 1
    Orthology source: HGNC
  • Links
    NCBI Gene ID: 92129
    neXtProt AC: NX_Q0D2K3
    UniProt: Q0D2K3

  • Chr Location
    Xq22.3; chrX:106900063-106903331 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    3 phenotypes from multigenic genotypes
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit extension of the seventh cervical vertebrae that fuses with the first rib. However, mice are otherwise viable.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 622473 NCBI Gene Model | MGI Sequence Detail 2673 C57BL/6J ±  kb
    transcript NM_001037915 RefSeq | MGI Sequence Detail 679 Not Specified  
    polypeptide Q2WG77 UniProt | EBI | MGI Sequence Detail 201 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 3
      cDNA 2
      Primer pair 1

      Microarray probesets 1
    References
    more
    • Summaries
      All 19
      Developmental Gene Expression 2
      Gene Ontology 3
      Phenotypes 5
    • Earliest
      J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
    • Latest
      J:199574 Takahashi Y, et al., Metameric pattern of intervertebral disc/vertebral body is generated independently of Mesp2/Ripply-mediated rostro-caudal patterning of somites in the mouse embryo. Dev Biol. 2013 Aug 15;380(2):172-84

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    last database update
    06/18/2019
    MGI 6.14
    The Jackson Laboratory