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Tmprss9 Gene Detail
Summary
  • Symbol
    Tmprss9
  • Name
    transmembrane protease, serine 9
  • Synonyms
    Serase-1B
  • Feature Type
    protein coding gene
  • IDs
    MGI:3612246
    NCBI Gene: 432478
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr10:80871848-80899492 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 39.72 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    105 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3612246
protein coding gene Chr10:80871117-80899495 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017526
protein coding gene Chr10:81548920-81570144 (+)
A/J MGP_AJ_G0017504
protein coding gene Chr10:78672601-78692769 (+)
AKR/J MGP_AKRJ_G0017465
protein coding gene Chr10:80829029-80850825 (+)
BALB/cJ MGP_BALBcJ_G0017466
protein coding gene Chr10:78888422-78908105 (+)
C3H/HeJ MGP_C3HHeJ_G0017289
protein coding gene Chr10:80920168-80941584 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017920
protein coding gene Chr10:84344812-84367752 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015609
protein coding gene Chr10:74882872-74902909 (+)
CAST/EiJ MGP_CASTEiJ_G0016856
protein coding gene Chr10:81148583-81169938 (+)
CBA/J MGP_CBAJ_G0017261
protein coding gene Chr10:87621582-87641247 (+)
DBA/2J MGP_DBA2J_G0017367
protein coding gene Chr10:77870219-77890184 (+)
FVB/NJ MGP_FVBNJ_G0017361
protein coding gene Chr10:77103920-77123470 (+)
LP/J MGP_LPJ_G0017438
protein coding gene Chr10:82002447-82022243 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017387
protein coding gene Chr10:89527731-89547433 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017961
protein coding gene Chr10:80822892-80842896 (+)
PWK/PhJ MGP_PWKPhJ_G0016637
protein coding gene Chr10:77764347-77784823 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016427
protein coding gene Chr10:79771804-79793874 (+)
WSB/EiJ MGP_WSBEiJ_G0016916
protein coding gene Chr10:80862824-80882352 (+)



Homology
more
  • Human Ortholog
    TMPRSS9, transmembrane serine protease 9
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TMPRSS9, transmembrane serine protease 9
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 360200
    neXtProt AC: NX_Q7Z410
    UniProt: Q7Z410

  • Chr Location
    19p13.3; chr19:2385254-2426261 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Tmprss9 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele show decreased social interest and social recognition and aged females show a borderline recognition memory deficit.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • cDNA Data
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000059406 Ensembl Gene Model | MGI Sequence Detail 27645 C57BL/6J ±  kb
    transcript ENSMUST00000105333 Ensembl | MGI Sequence Detail 3497 Not Applicable  
    polypeptide ENSMUSP00000100970 Ensembl | MGI Sequence Detail 1099 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 3
      cDNA 3

      Microarray probesets 1
    References
    more
    • Summaries
      All 20
      Diseases 1
      Gene Ontology 1
      Phenotypes 6
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:284914 Chen CA, et al., Combination of whole exome sequencing and animal modeling identifies TMPRSS9 as a candidate gene for autism spectrum disorder. Hum Mol Genet. 2020 Feb 1;29(3):459-470

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    last database update
    02/23/2021
    MGI 6.16
    The Jackson Laboratory