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Nlrc5
Gene Detail
Symbol

Name
ID
Nlrc5
NLR family, CARD domain containing 5
MGI:3612191
Synonyms
AI451557
Feature Type
protein coding gene
Genetic Map
Chromosome 8
46.55 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr8:94472763-94527272 bp, + strand
From VEGA annotation of GRCm38

  54510 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:88935  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: NLRC5
Gene Tree: Nlrc5

Human
homologs
NLRC5, NLR family, CARD domain containing 5
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 84166
neXtProt AC: NX_Q86WI3

Human Synonyms: CLR16.1, NOD27, NOD4

Human Chr (Location): 16q13; chr16:56989547-57083526 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele exhibit normal cytokine production induced by virus and bacteria infection.
 
Interactions
Nlrc5 interacts with 21 markers (Mir18, Mir18b, Mir122, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process immune system process, innate immune response, ...
Component cytoplasm, cytosol, ...
Function ATP binding, nucleotide binding, ...
External Resources: FuncBase
Expression
cDNA source data(40)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase cetp    NEW 
Molecular
reagents
All nucleic(40) cDNA(40)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000033926 (Evidence)
Ensembl Gene Model ENSMUSG00000074151 (Evidence)
Entrez Gene 434341 (Evidence)
UniGene 334720
DFCI TC1581803, TC1663685
DoTS DT.101368973, DT.110844689
NIA Mouse Gene Index U155248, U329049
PDB 2MJM
Consensus CDS Project CCDS59741.1
International Mouse Phenotyping Consortium Status Nlrc5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033926 VEGA Gene Model | MGI Sequence Detail 54510 C57BL/6J ±  kb
transcript OTTMUST00000113571 VEGA | MGI Sequence Detail 6945 Not Applicable 
polypeptide OTTMUSP00000063496 VEGA | MGI Sequence Detail 1915 Not Applicable 

For the selected sequences
All sequences(49) RefSeq(14) UniProt(3)
Polymorphisms
SNPs within 2kb(248 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007111 NACHT nucleoside triphosphatase
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000011263 protein NLRC5
References
(Earliest) J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
(Latest) J:189799 Biswas A, et al., Cutting edge: impaired MHC class I expression in mice deficient for Nlrc5/class I transactivator. J Immunol. 2012 Jul 15;189(2):516-20
All references(31)
Other
accession IDs
MGI:2142553

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory