About   Help   FAQ
Trim72 Gene Detail
Summary
  • Symbol
    Trim72
  • Name
    tripartite motif-containing 72
  • Synonyms
    MG53, mitsugumin 53
  • Feature Type
    protein coding gene
  • IDs
    MGI:3612190
    NCBI Gene: 434246
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:127603121-127610205 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 69.89 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    89 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3612190
 protein coding gene Chr7:127602684-127610565 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033069
 protein coding gene Chr7:132401758-132409107 (+)
A/J MGP_AJ_G0033052
 protein coding gene Chr7:128849873-128857234 (+)
AKR/J MGP_AKRJ_G0032984
 protein coding gene Chr7:132193158-132200242 (+)
BALB/cJ MGP_BALBcJ_G0033053
 protein coding gene Chr7:128509796-128516880 (+)
C3H/HeJ MGP_C3HHeJ_G0032767
 protein coding gene Chr7:132092741-132099825 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033562
 protein coding gene Chr7:137550985-137558069 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030535
 protein coding gene Chr7:130040321-130047873 (+)
CAST/EiJ MGP_CASTEiJ_G0032096
 protein coding gene Chr7:123884054-123891411 (+)
CBA/J MGP_CBAJ_G0032740
 protein coding gene Chr7:142227138-142234222 (+)
DBA/2J MGP_DBA2J_G0032892
 protein coding gene Chr7:126829116-126836200 (+)
FVB/NJ MGP_FVBNJ_G0032845
 protein coding gene Chr7:126689991-126697086 (+)
LP/J MGP_LPJ_G0032986
 protein coding gene Chr7:133866174-133873523 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032877
 protein coding gene Chr7:143299564-143306648 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033582
 protein coding gene Chr7:131176024-131183108 (+)
PWK/PhJ MGP_PWKPhJ_G0031803
 protein coding gene Chr7:119836046-119843397 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031649
 protein coding gene Chr7:117981719-117989049 (+)
WSB/EiJ MGP_WSBEiJ_G0032208
 protein coding gene Chr7:132141049-132148133 (+)



Homology
more
  • Human Ortholog
    TRIM72, tripartite motif containing 72
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TRIM72, tripartite motif containing 72
  • Synonyms
    MG53
  • Links
    NCBI Gene ID: 493829
    neXtProt AC: NX_Q6ZMU5
    UniProt: Q6ZMU5

  • Chr Location
    16p11.2; chr16:31214119-31231537 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 3 alleles in 2 genetic backgrounds
    31 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice with disruption of this gene display muscle pathologies that develop with age. Mice homozygous for a knock-out allele exhibit enhanced myogenesis. Homozygosity for the p.C14A mutation ameliorates the effects of a high-fat diet without affecting susceptibility to myocardial ischemic injury.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    29
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    761
  • Tissues
    29
  • cDNA Data
    13
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000042828 Ensembl Gene Model | MGI Sequence Detail 7085 C57BL/6J ±  kb
    transcript ENSMUST00000106248 Ensembl | MGI Sequence Detail 2134 Not Applicable  
    polypeptide ENSMUSP00000101855 Ensembl | MGI Sequence Detail 477 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 14

      Microarray probesets 1
    References
    more
    • Summaries
      All 62
      Developmental Gene Expression 2
      Gene Ontology 10
      Phenotypes 31
    • Earliest
      J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
    • Latest
      J:333080 Wu M, et al., TRIM72 Alleviates Muscle Inflammation in mdx Mice via Promoting Mitophagy-Mediated NLRP3 Inflammasome Inactivation. Oxid Med Cell Longev. 2023;2023:8408574
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory