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Cyp4a12b Gene Detail
Summary
  • Symbol
    Cyp4a12b
  • Name
    cytochrome P450, family 4, subfamily a, polypeptide 12B
  • Feature Type
    protein coding gene
  • IDs
    MGI:3611747
    NCBI Gene: 13118
  • Gene Overview
    MyGene.info: CYP4A22
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr4:115411624-115439034 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 52.99 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    132 from dbSNP Build 142
  • Strain Annotations
    13
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3611747
protein coding gene Chr4:115411624-115439034 (.)
129S1/SvImJ MGP_129S1SvImJ_G0028599
protein coding gene Chr4:116209117-116239042 (+)
A/J no annotation
AKR/J MGP_AKRJ_G0028509
protein coding gene Chr4:114095375-114130609 (+)
BALB/cJ MGP_BALBcJ_G0028581
protein coding gene Chr4:112392368-112419315 (+)
C3H/HeJ MGP_C3HHeJ_G0028295
protein coding gene Chr4:115561896-115714879 (+)
C57BL/6NJ no annotation
CAROLI/EiJ MGP_CAROLIEiJ_G0026309
protein coding gene Chr4:105733308-105754709 (+)
CAST/EiJ no annotation
CBA/J MGP_CBAJ_G0028262
protein coding gene Chr4:123747617-123782348 (+)
DBA/2J no annotation
FVB/NJ no annotation
LP/J MGP_LPJ_G0028513
protein coding gene Chr4:116358365-116398562 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028405
protein coding gene Chr4:128873693-128917963 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029061
protein coding gene Chr4:115329417-115351414 (+)
PWK/PhJ MGP_PWKPhJ_G0027457
protein coding gene Chr4:109191431-109226959 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027281
protein coding gene Chr4:111642240-111662662 (+)
WSB/EiJ MGP_WSBEiJ_G0027809
protein coding gene Chr4:115017103-115193879 (+)



Homology
more
  • Human Ortholog
    CYP4A22, cytochrome P450 family 4 subfamily A member 22
  • Vertebrate Orthologs
    12
  • Human Ortholog
    CYP4A22, cytochrome P450 family 4 subfamily A member 22
    Orthology source: HomoloGene
  • Links
    NCBI Gene ID: 284541
    neXtProt AC: NX_Q5TCH4
    UniProt: Q5TCH4

  • Chr Location
    1p33; chr1:47137425-47149738 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 13118 NCBI Gene Model | MGI Sequence Detail 27411 C57BL/6J ±  kb
transcript NM_172306 RefSeq | MGI Sequence Detail 2395 C57BL/6  
polypeptide NP_758510 RefSeq | MGI Sequence Detail 508 C57BL/6  
For the selected sequence
Protein
Information
less
  • UniProt
    3 Sequences
  • InterPro Domains
    IPR001128 Cytochrome P450
    IPR017972 Cytochrome P450, conserved site
    IPR002401 Cytochrome P450, E-class, group I
    IPR036396 Cytochrome P450 superfamily
Molecular
Reagents
less
  • All nucleic 9
    Genomic 1
    cDNA 7
    Primer pair 1

    Microarray probesets 2
References
more
  • Summaries
    All 29
    Developmental Gene Expression 2
    Gene Ontology 2
    Phenotypes 7
  • Earliest
    J:4152 Nelson DR, et al., The P450 superfamily: update on new sequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclature. DNA Cell Biol. 1993 Jan-Feb;12(1):1-51
  • Latest
    J:148802 Boles MK, et al., A mouse chromosome 4 balancer ENU-mutagenesis screen isolates eleven lethal lines. BMC Genet. 2009;10:12

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory