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Cyp4a12b Gene Detail
Summary
  • Symbol
    Cyp4a12b
  • Name
    cytochrome P450, family 4, subfamily a, polypeptide 12B
  • Feature Type
    protein coding gene
  • IDs
    MGI:3611747
    NCBI Gene: 13118
  • Gene Overview
    MyGene.info: CYP4A22
Location & Maps
more
  • Sequence Map
    Chr4:115411624-115439034 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      27411 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 52.99 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    CYP4A22, cytochrome P450 family 4 subfamily A member 22
  • Vertebrate Orthologs
    12
  • Human Ortholog
    CYP4A22, cytochrome P450 family 4 subfamily A member 22
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 284541
    neXtProt AC: NX_Q5TCH4

  • Chr Location
    1p33; chr1:47137435-47149738 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotype references
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    2
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    4 involving Cyp4a12b
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Other Mouse Links
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000008618 VEGA Gene Model | MGI Sequence Detail 27411 C57BL/6J ±  kb
transcript OTTMUST00000019517 VEGA | MGI Sequence Detail 2395 Not Applicable  
polypeptide OTTMUSP00000008956 VEGA | MGI Sequence Detail 508 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    132 from dbSNP Build 142
Protein
Information
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  • UniProt
    3 Sequences
  • InterPro Domains
    IPR001128 Cytochrome P450
    IPR017972 Cytochrome P450, conserved site
    IPR002401 Cytochrome P450, E-class, group I
Molecular
Reagents
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  • All nucleic 9
    Genomic 1
    cDNA 7
    Primer pair 1

    Microarray probesets 2
References
more
  • Summaries
    All 20
    Developmental Gene Expression 2
    Gene Ontology 1
    Phenotypes 7
  • Earliest
    J:42094 Heng YM, et al., A novel murine P-450 gene, Cyp4a14, is part of a cluster of Cyp4a and Cyp4b, but not of CYP4F, genes in mouse and humans. Biochem J. 1997 Aug 1;325(Pt 3):741-9
  • Latest
    J:121394 Muller DN, et al., Mouse Cyp4a isoforms: enzymatic properties, gender- and strain-specific expression, and role in renal 20-hydroxyeicosatetraenoic acid formation. Biochem J. 2007 Apr 1;403(1):109-18

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory