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Rapgefl1 Gene Detail
Summary
  • Symbol
    Rapgefl1
  • Name
    Rap guanine nucleotide exchange factor (GEF)-like 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:3611446
    NCBI Gene: 268480
Location & Maps
more
  • Sequence Map
    Chr11:98836785-98853697 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      16913 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 62.70 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    RAPGEFL1, Rap guanine nucleotide exchange factor like 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    RAPGEFL1, Rap guanine nucleotide exchange factor like 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    Link-GEFII
  • Links
    NCBI Gene ID: 51195
    neXtProt AC: NX_Q9UHV5

  • Chr Location
    17q21.1; chr17:40177010-40195656 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    3
  • Targeted
    3
  • Genomic Mutations
    1 involving Rapgefl1
  • Incidental Mutations
    APF , CvDC
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006452 VEGA Gene Model | MGI Sequence Detail 16913 C57BL/6J ±  kb
transcript OTTMUST00000014743 VEGA | MGI Sequence Detail 4855 Not Applicable  
polypeptide OTTMUSP00000006850 VEGA | MGI Sequence Detail 662 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    72 from dbSNP Build 142
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000013732 rap guanine nucleotide exchange factor-like 1
  • InterPro Domains
    IPR023578 Ras guanine nucleotide exchange factor domain
    IPR001895 Ras guanine-nucleotide exchange factors catalytic domain
    IPR029071 Ubiquitin-related domain
Molecular
Reagents
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  • All nucleic 28
    cDNA 28

    Microarray probesets 1
References
more
  • Summaries
    All 18
    Gene Ontology 2
    Phenotypes 8
  • Earliest
    J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory