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Rapgefl1 Gene Detail
Summary
  • Symbol
    Rapgefl1
  • Name
    Rap guanine nucleotide exchange factor (GEF)-like 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:3611446
    NCBI Gene: 268480
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:98836785-98853009 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 62.70 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    71 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3611446
protein coding gene Chr11:98836785-98853697 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019075
protein coding gene Chr11:101446713-101469175 (+)
A/J MGP_AJ_G0019043
protein coding gene Chr11:97193764-97210602 (+)
AKR/J MGP_AKRJ_G0019013
protein coding gene Chr11:100204144-100220976 (+)
BALB/cJ MGP_BALBcJ_G0019017
protein coding gene Chr11:97690463-97707785 (+)
C3H/HeJ MGP_C3HHeJ_G0018830
protein coding gene Chr11:100351098-100368822 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019468
protein coding gene Chr11:104549411-104567977 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017100
protein coding gene Chr11:94752246-94769342 (+)
CAST/EiJ MGP_CASTEiJ_G0018384
protein coding gene Chr11:101336569-101353330 (+)
CBA/J MGP_CBAJ_G0018801
protein coding gene Chr11:108903291-108936919 (+)
DBA/2J MGP_DBA2J_G0018909
protein coding gene Chr11:96754609-96772615 (+)
FVB/NJ MGP_FVBNJ_G0018898
protein coding gene Chr11:96267336-96284849 (+)
LP/J MGP_LPJ_G0018979
protein coding gene Chr11:101902818-101924973 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018925
protein coding gene Chr11:108606914-108627370 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019508
protein coding gene Chr11:100556602-100575508 (+)
PWK/PhJ MGP_PWKPhJ_G0018155
protein coding gene Chr11:97794494-97811871 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017944
protein coding gene Chr11:100299954-100316513 (+)
WSB/EiJ MGP_WSBEiJ_G0018433
protein coding gene Chr11:100513562-100533731 (+)



Homology
more
  • Human Ortholog
    RAPGEFL1, Rap guanine nucleotide exchange factor like 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    RAPGEFL1, Rap guanine nucleotide exchange factor like 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    Link-GEFII
  • Links
    NCBI Gene ID: 51195
    neXtProt AC: NX_Q9UHV5
    UniProt: Q9UHV5

  • Chr Location
    17q21.1; chr17:40177010-40195656 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 268480 NCBI Gene Model | MGI Sequence Detail 16225 C57BL/6J ±  kb
transcript NM_001080925 RefSeq | MGI Sequence Detail 4163 Not Specified  
polypeptide Q68EF8 UniProt | EBI | MGI Sequence Detail 662 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000013732 Rap guanine nucleotide exchange factor-like 1
  • InterPro Domains
    IPR036964 Ras guanine-nucleotide exchange factor catalytic domain superfamily
    IPR023578 Ras guanine nucleotide exchange factor domain superfamily
    IPR001895 Ras guanine-nucleotide exchange factors catalytic domain
    IPR008937 Ras-like guanine nucleotide exchange factor
    IPR029071 Ubiquitin-like domain superfamily
Molecular
Reagents
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  • All nucleic 29
    cDNA 29

    Microarray probesets 1
References
more
  • Summaries
    All 23
    Gene Ontology 2
    Phenotypes 8
  • Earliest
    J:56548 Zheng B, et al., Engineering a mouse balancer chromosome. Nat Genet. 1999 Aug;22(4):375-8
  • Latest
    J:174216 Terzian T, et al., Rpl27a mutation in the sooty foot ataxia mouse phenocopies high p53 mouse models. J Pathol. 2011 Aug;224(4):540-52

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory