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Tox2 Gene Detail
Summary
  • Symbol
    Tox2
  • Name
    TOX high mobility group box family member 2
  • Synonyms
    LOC269389, RxHMG1
  • Feature Type
    protein coding gene
  • IDs
    MGI:3611233
    NCBI Gene: 269389
  • Alliance
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:163202643-163323315 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 84.14 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    751 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3611233
protein coding gene Chr2:163202643-163324170 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026819
protein coding gene Chr2:168525571-168655913 (+)
A/J MGP_AJ_G0026785
protein coding gene Chr2:161745126-161867701 (+)
AKR/J MGP_AKRJ_G0026756
protein coding gene Chr2:166525398-166650013 (+)
BALB/cJ MGP_BALBcJ_G0026794
protein coding gene Chr2:162072506-162195712 (+)
C3H/HeJ MGP_C3HHeJ_G0026536
protein coding gene Chr2:166866800-166993334 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027242
protein coding gene Chr2:173458532-173592204 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024612
protein coding gene Chr2:155034110-155154891 (+)
CAST/EiJ MGP_CASTEiJ_G0025997
protein coding gene Chr2:167240885-167374425 (+)
CBA/J MGP_CBAJ_G0026513
protein coding gene Chr2:179752371-179878188 (+)
DBA/2J MGP_DBA2J_G0026651
protein coding gene Chr2:160912434-161035161 (+)
FVB/NJ MGP_FVBNJ_G0026617
protein coding gene Chr2:159286464-159410492 (+)
LP/J MGP_LPJ_G0026754
protein coding gene Chr2:168664664-168794936 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026639
protein coding gene Chr2:183404854-183532846 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027298
protein coding gene Chr2:166414361-166538746 (+)
PWK/PhJ MGP_PWKPhJ_G0025731
protein coding gene Chr2:160467713-160590768 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025534
protein coding gene Chr2:165276564-165409796 (+)
WSB/EiJ MGP_WSBEiJ_G0026067
protein coding gene Chr2:167272363-167398873 (+)



Homology
more
  • Human Ortholog
    TOX2, TOX high mobility group box family member 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TOX2, TOX high mobility group box family member 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C20orf100, dJ1108D11.2, dJ495O3.1, GCX1, GCX-1
  • Links
    NCBI Gene ID: 84969
    neXtProt AC: NX_Q96NM4
    UniProt: Q96NM4

  • Chr Location
    20q13.12; chr20:43914852-44069616 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 13155
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: TOX2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 269389 NCBI Gene Model | MGI Sequence Detail 120673 C57BL/6J ±  kb
    transcript NM_001363063 RefSeq | MGI Sequence Detail 2940 C57BL/6  
    polypeptide NP_001092269 RefSeq | MGI Sequence Detail 522 C57BL/6  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • InterPro Domains
      IPR009071 High mobility group box domain
      IPR036910 High mobility group box domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 7
      cDNA 3
      Primer pair 4

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:2139084, MGI:2139242
    References
    more
    • Summaries
      All 21
      Developmental Gene Expression 4
      Gene Ontology 2
      Phenotypes 3
    • Earliest
      J:93300 Blackshaw S, et al., Genomic analysis of mouse retinal development. PLoS Biol. 2004 Oct;2(9):E247
    • Latest
      J:264370 Sima J, et al., Eda-activated RelB recruits an SWI/SNF (BAF) chromatin-remodeling complex and initiates gene transcription in skin appendage formation. Proc Natl Acad Sci U S A. 2018 Aug 7;115(32):8173-8178

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    04/16/2019
    MGI 6.13
    The Jackson Laboratory