Ksr2 MGI Mouse Gene Detail - MGI:3610315 - kinase suppressor of ras 2

Symbol

Ksr2
Name

kinase suppressor of ras 2

Feature Type

protein coding gene
IDs

MGI:3610315
NCBI Gene: 333050
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr5:117552067-117906061 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 56.88 cM
Mapping Data

1 experiment

SNPs within 2kb

2599 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3610315	protein coding gene	Chr5:117552036-117913068 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0029989	protein coding gene	Chr5:120503015-120887419 (+)
A/J	MGP_AJ_G0029953	protein coding gene	Chr5:115596824-115962897 (+)
AKR/J	MGP_AKRJ_G0029892	protein coding gene	Chr5:119333655-119709123 (+)
BALB/cJ	MGP_BALBcJ_G0029964	protein coding gene	Chr5:117016432-117385437 (+)
C3H/HeJ	MGP_C3HHeJ_G0029684	protein coding gene	Chr5:119853287-120224851 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0030419	protein coding gene	Chr5:125086207-125475981 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027645	protein coding gene	Chr5:110358638-110733780 (+)
CAST/EiJ	MGP_CASTEiJ_G0029093	protein coding gene	Chr5:118859469-119249984 (+)
CBA/J	MGP_CBAJ_G0029652	protein coding gene	Chr5:129909814-130306641 (+)
DBA/2J	MGP_DBA2J_G0029802	protein coding gene	Chr5:115696650-116061096 (+)
FVB/NJ	MGP_FVBNJ_G0029758	protein coding gene	Chr5:114561549-114944590 (+)
LP/J	MGP_LPJ_G0029890	protein coding gene	Chr5:121000292-121376508 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029789	protein coding gene	Chr5:134128459-134520484 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030460	protein coding gene	Chr5:118861135-119246869 (+)
PWK/PhJ	MGP_PWKPhJ_G0028806	protein coding gene	Chr5:114392116-114766375 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0028644	protein coding gene	Chr5:116429345-116822660 (+)
WSB/EiJ	MGP_WSBEiJ_G0029168	protein coding gene	Chr5:119434887-119820148 (+)

Human Ortholog

KSR2, kinase suppressor of ras 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

KSR2, kinase suppressor of ras 2
Links

HGNC:18610

NCBI Gene ID: 283455

neXtProt AC: NX_Q6VAB6

UniProt: Q6VAB6
Chr Location

12q24.22-q24.23; chr12:117453012-117968990 (-) GRCh38

MGI Vertebrate Homology

Ksr2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: KSR2
Gene Tree

Ksr2

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Phenotype Summary

3 phenotypes from 3 alleles in 2 genetic backgrounds
20 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Chemically induced (ENU)

1
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

1
Radiation induced

1
Spontaneous

1
Targeted

7
Genomic Mutations

2 involving Ksr2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

42 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mice exhibit increased body fat and obesity, resulting from hyperphagia. Mice are also glucose intolerant and have high serum cholesterol, ALT, serum lipids and show hepatic steatosis.

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All GO Annotations

21
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

4
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas

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All Sequences

47
RefSeq

8
UniProt

5
CCDS

CCDS19605.1

Ensembl

ENSMUSG00000061578 (Evidence)
NCBI Gene

333050

			Length	Strain/Species	Flank
genomic	333050	NCBI Gene Model \| MGI Sequence Detail	353995	C57BL/6J	± kb
transcript	NM_001312914	RefSeq \| MGI Sequence Detail	6124	C57BL/6
polypeptide	Q3UVC0	UniProt \| EBI \| MGI Sequence Detail	951	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000009592 kinase suppressor of Ras 2

(term hierarchy)
EC

2.7.11.1
InterPro Domains

IPR046349 C1-like domain superfamily

IPR025561 Kinase suppressor of RAS, SAM-like domain

IPR046861 Kinase suppressor RAS 1, N-terminal helical hairpin

IPR046933 Kinase suppressor RAS 1, N-terminal helical hairpin superfamily

IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR008271 Serine/threonine-protein kinase, active site

IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain

IPR013761 Sterile alpha motif/pointed domain superfamily

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All nucleic 4

cDNA 4

Microarray probesets 1

Summaries

All 42

Developmental Gene Expression 1

Gene Ontology 8

Phenotypes 20
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:345122 Gomez GA, et al., Contrasting effects of Ksr2, an obesity gene, on trabecular bone volume and bone marrow adiposity. Elife. 2022 Nov 7;11:e82810

TSS for Ksr2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr48389	Chr5:117551831-117551850 (+)	-226 bp
Tssr48390	Chr5:117551875-117551887 (+)	-186 bp
Tssr48391	Chr5:117552042-117552076 (+)	-8 bp
Tssr1612	Chr5:117552490-117552569 (+)	463 bp
Tssr48392	Chr5:117552872-117552888 (+)	813 bp
Tssr48393	Chr5:117555753-117555774 (+)	3,697 bp
Tssr48394	Chr5:117647865-117647872 (+)	95,802 bp
Tssr48395	Chr5:117648007-117648019 (+)	95,946 bp
Tssr48396	Chr5:117648308-117648315 (+)	96,245 bp
Tssr48397	Chr5:117797968-117797984 (+)	245,909 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23