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Ksr2 Gene Detail
Summary
  • Symbol
    Ksr2
  • Name
    kinase suppressor of ras 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:3610315
    NCBI Gene: 333050
  • Gene Overview
    MyGene.info: KSR2
Location & Maps
more
  • Sequence Map
    Chr5:117414000-117775003 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      361004 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 56.88 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    KSR2, kinase suppressor of ras 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    KSR2, kinase suppressor of ras 2
    Orthology source: HomoloGene
  • Links
    NCBI Gene ID: 283455
    neXtProt AC: NX_Q6VAB6

  • Chr Location
    12q24.22-q24.23; chr12:117453012-117969103 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 3 alleles in 2 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    10
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    1
  • Gene trapped
    2
  • Radiation induced
    1
  • Targeted
    5
  • Genomic Mutations
    2 involving Ksr2
  • Incidental Mutations
Homozygous mice exhibit increased body fat and obesity, resulting from hyperphagia. Mice are also glucose intolerant and have high serum cholesterol, ALT, serum lipids and show hepatic steatosis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026829 VEGA Gene Model | MGI Sequence Detail 361004 C57BL/6J ±  kb
transcript OTTMUST00000066347 VEGA | MGI Sequence Detail 13125 Not Applicable  
polypeptide OTTMUSP00000033238 VEGA | MGI Sequence Detail 951 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    2671 from dbSNP Build 142
Protein
Information
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  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000009592 kinase suppressor of Ras 2
  • EC
  • InterPro Domains
    IPR025561 Kinase suppressor of RAS, SAM-like domain
    IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
    IPR000719 Protein kinase domain
    IPR011009 Protein kinase-like domain
    IPR008271 Serine/threonine-protein kinase, active site
    IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
Molecular
Reagents
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  • All nucleic 4
    cDNA 4

    Microarray probesets 1
References
more
  • Summaries
    All 25
    Developmental Gene Expression 1
    Gene Ontology 3
    Phenotypes 13
  • Earliest
    J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
  • Latest
    J:224081 Moretti E, et al., Ultrastructural study of spermatogenesis in KSR2 deficient mice. Transgenic Res. 2015 Aug;24(4):741-51

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory