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Chrna10
Gene Detail
Symbol

Name
ID
Chrna10
cholinergic receptor, nicotinic, alpha polypeptide 10
MGI:3609260
Feature Type
protein coding gene
Genetic Map
Chromosome 7
54.71 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr7:102111266-102116713 bp, - strand
From Ensembl annotation of GRCm38

  5448 bp   ±  kb flank

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Mouse Genome Browser
Vertebrate
homology
HomoloGene:56886  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CHRNA10
Gene Tree: Chrna10

Human
homologs
CHRNA10, cholinergic receptor, nicotinic, alpha 10 (neuronal)
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 57053
neXtProt AC: NX_Q9GZZ6

Human Chr (Location): 11p15.5; chr11:3665587-3673208 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous mutation of this gene results in impaired synaptic function and integrity of the olivocochlear system.
 
Interactions
Chrna10 interacts with 92 markers (Mir15a, Mir15b, Mir16-1, ...)
Expression
Literature Summary: (2 records)
cDNA source data(4)
Other mouse links: GEO   Expression Atlas
Molecular
reagents
All nucleic(4) cDNA(4)
Microarray probesets(1)
Other database
links
Ensembl Gene Model ENSMUSG00000066279 (Evidence)
Entrez Gene 504186 (Evidence)
UniGene 334074
DFCI TC1618142
DoTS DT.101716233
NIA Mouse Gene Index U028938
Consensus CDS Project CCDS40047.1
International Mouse Phenotyping Consortium Status Chrna10
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000066279 Ensembl Gene Model | MGI Sequence Detail 5448 C57BL/6J ±  kb
transcript ENSMUST00000084830 Ensembl | MGI Sequence Detail 2513 Not Applicable 
polypeptide ENSMUSP00000081891 Ensembl | MGI Sequence Detail 447 Not Applicable 

For the selected sequences
All sequences(19) RefSeq(6) UniProt(1)
Polymorphisms
SNPs within 2kb(144 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006201 Neurotransmitter-gated ion-channel
InterPro IPR018000 Neurotransmitter-gated ion-channel, conserved site
InterPro IPR006202 Neurotransmitter-gated ion-channel ligand-binding domain
InterPro IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
InterPro IPR027361 Nicotinic acetylcholine-gated receptor, transmembrane domain
InterPro IPR002394 Nicotinic acetylcholine receptor
Protein Ontology PR:000005454 neuronal acetylcholine receptor subunit alpha-10
References
(Earliest) J:130585 Vetter DE, et al., The alpha10 nicotinic acetylcholine receptor subunit is required for normal synaptic function and integrity of the olivocochlear system. Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20594-9
(Latest) J:189624 Son EJ, et al., Developmental gene expression profiling along the tonotopic axis of the mouse cochlea. PLoS One. 2012;7(7):e40735
All references(22)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory