About   Help   FAQ
Chrna10
Gene Detail
 Symbol
Name
ID
Chrna10
cholinergic receptor, nicotinic, alpha polypeptide 10
MGI:3609260
Feature Type protein coding gene
Genetic Map
Chromosome 7
54.71 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr7:102111266-102116713 bp, - strand
From NCBI annotation of GRCm38

  5448 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56886  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Chrna10

Human
homologs
Human Homolog CHRNA10, cholinergic receptor, nicotinic, alpha 10 (neuronal)
NCBI Gene ID 57053
neXtProt AC  NX_Q9GZZ6
Human Chr (Location)  11p15.5; chr11:3665587-3671384 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in impaired synaptic function and integrity of the olivocochlear system.
 
Interactions
Chrna10 interacts with 92 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process cation transmembrane transport, detection of mechanical stimulus involved in sensory perception of sound, ...
Component acetylcholine-gated channel complex, axon, ...
Function acetylcholine-activated cation-selective channel activity
Expression
Literature Summary: (2 records)
cDNA source data(4)
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(4) cDNA(4)
Microarray probesets(1)
Other database
links
Ensembl Gene ModelENSMUSG00000066279 (Evidence)
Entrez Gene504186 (Evidence)
UniGene334074
DFCITC1618142
DoTSDT.101716233
NIA Mouse Gene IndexU028938
Consensus CDS ProjectCCDS40047.1
International Mouse Knockout Project StatusChrna10
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 504186 NCBI Gene Model | MGI Sequence Detail 5448 C57BL/6J ±  kb
transcript NM_001081424 RefSeq | MGI Sequence Detail 2513 Not Specified 
polypeptide NP_001074893 RefSeq | MGI Sequence Detail 447 Not Specified 

For the selected sequences
All sequences(19) RefSeq(6) UniProt(1)
Polymorphisms SNPs within 2kb(144 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006201 Neurotransmitter-gated ion-channel
InterPro IPR018000 Neurotransmitter-gated ion-channel, conserved site
InterPro IPR006202 Neurotransmitter-gated ion-channel ligand-binding
InterPro IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
InterPro IPR027361 Nicotinic acetylcholine-gated receptor, transmembrane domain
InterPro IPR002394 Nicotinic acetylcholine receptor
Protein Ontology PR:000005454 neuronal acetylcholine receptor subunit alpha-10
References (Earliest) J:130585 Vetter DE, et al., The alpha10 nicotinic acetylcholine receptor subunit is required for normal synaptic function and integrity of the olivocochlear system. Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20594-9
(Latest) J:189624 Son EJ, et al., Developmental gene expression profiling along the tonotopic axis of the mouse cochlea. PLoS One. 2012;7(7):e40735
All references(25)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/09/2014
MGI 5.19
The Jackson Laboratory