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Chrna10 Gene Detail
Summary
  • Symbol
    Chrna10
  • Name
    cholinergic receptor, nicotinic, alpha polypeptide 10
  • Feature Type
    protein coding gene
  • IDs
    MGI:3609260
    NCBI Gene: 504186
  • Gene Overview
    MyGene.info: CHRNA10
Location & Maps
more
  • Sequence Map
    Chr7:102111266-102116713 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      5448 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    CHRNA10, cholinergic receptor nicotinic alpha 10 subunit
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CHRNA10, cholinergic receptor nicotinic alpha 10 subunit
    Orthology source: HomoloGene
  • Links
    NCBI Gene ID: 57053
    neXtProt AC: NX_Q9GZZ6

  • Chr Location
    11p15.5; chr11:3665587-3673208 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    2 involving Chrna10
  • Incidental Mutations
Homozygous mutation of this gene results in impaired synaptic function and integrity of the olivocochlear system.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000066279 Ensembl Gene Model | MGI Sequence Detail 5448 C57BL/6J ±  kb
transcript ENSMUST00000084830 Ensembl | MGI Sequence Detail 2513 Not Applicable  
polypeptide ENSMUSP00000081891 Ensembl | MGI Sequence Detail 447 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    144 from dbSNP Build 142
Protein
Information
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  • UniProt
    1 Sequence
  • InterPro Domains
    IPR006201 Neurotransmitter-gated ion-channel
    IPR018000 Neurotransmitter-gated ion-channel, conserved site
    IPR006202 Neurotransmitter-gated ion-channel ligand-binding domain
    IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
    IPR027361 Nicotinic acetylcholine-gated receptor, transmembrane domain
    IPR002394 Nicotinic acetylcholine receptor
Molecular
Reagents
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  • All nucleic 4
    cDNA 4

    Microarray probesets 1
References
more
  • Summaries
    All 20
    Developmental Gene Expression 2
    Gene Ontology 4
    Phenotypes 13
  • Earliest
    J:130585 Vetter DE, et al., The alpha10 nicotinic acetylcholine receptor subunit is required for normal synaptic function and integrity of the olivocochlear system. Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20594-9
  • Latest
    J:189624 Son EJ, et al., Developmental gene expression profiling along the tonotopic axis of the mouse cochlea. PLoS One. 2012;7(7):e40735

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory