Tmem132b Gene Detail

Summary

• Symbol
  Tmem132b
• Name
  transmembrane protein 132B

• Feature Type
  protein coding gene
• IDs
  MGI:3609245
  NCBI Gene: 208151

Location & Maps

• Sequence Map
  Chr5:125531774-125792583 bp, + strand
• From VEGA annotation of GRCm38
  

  Mouse Genome Browser
  
  

• Download
  Sequence
    260810 bp   ±  kb flank
  
  
• Genome Browsers
  VEGA | Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 5, 64.27 cM
• Mapping Data
  1 experiment

Homology

• Human Ortholog
  TMEM132B, transmembrane protein 132B

• Vertebrate Orthologs
  8

• Human Ortholog
  TMEM132B, transmembrane protein 132B
  Orthology source: HomoloGene, HGNC
• Links
  HGNC:29397

  NCBI Gene ID: 114795

  neXtProt AC: NX_Q14DG7

  UniProt: Q14DG7

  
  
• Chr Location
  12q24.31-q24.32; chr12:125186750-125662377 (+)  GRCh38.p7

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• HomoloGene
  Vertebrate Homology Class 28135
  1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 frog, western clawed
  
• HCOP
  human homology predictions: TMEM132B
• Gene Tree
  Tmem132b
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  7 phenotype references
  

• All Mutations and Alleles
  10
• Chemically induced (other)
  1
• Gene trapped
  8
• Radiation induced
  1
• Genomic Mutations
  2 involving Tmem132b
• Incidental Mutations
  Mutagenetix , APF
• Find Mice (IMSR)
  23 strains or lines available

Gene Ontology
(GO)
Classifications

• All GO Annotations
  1
• GO References
  1

Expression

• cDNA Data
  13

• Other Mouse Links
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase tmem132b

Interactions

• Tmem132b interacts with 413 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

Sequences &
Gene Models

• All Sequences
  19
• RefSeq
  2
• UniProt
  3
• CCDS
  CCDS57384.1
• UniGene
  40397

• VEGA
  OTTMUSG00000044549 (Evidence)
• Ensembl
  ENSMUSG00000070498 (Evidence)
• NCBI Gene
  208151

Representative Sequences			Length	Strain/Species
genomic	OTTMUSG00000044549	VEGA Gene Model | MGI Sequence Detail	260810	C57BL/6J
transcript	OTTMUST00000117252	VEGA | MGI Sequence Detail	7995	Not Applicable
polypeptide	OTTMUSP00000065576	VEGA | MGI Sequence Detail	1078	Not Applicable

Polymorphisms

• SNPs within 2kb
  1940 from dbSNP Build 142

Protein
Information

• UniProt
  3 Sequences
• InterPro Domains
  IPR026307 Transmembrane protein 132
  IPR031437 Transmembrane protein family 132, middle domain
  IPR031436 Transmembrane protein TMEM132, C-terminal
  IPR031435 Transmembrane protein TMEM132, N-terminal

Molecular
Reagents

• All nucleic 13

  cDNA 13

  
  

  Microarray probesets 3

References

• Summaries
  All 20

  Gene Ontology 1

  Phenotypes 7
• Earliest
  J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
• Latest
  J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14