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Mrap2 Gene Detail
Summary
  • Symbol
    Mrap2
  • Name
    melanocortin 2 receptor accessory protein 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:3609239
    NCBI Gene: 244958
  • Gene Overview
    MyGene.info: MRAP2
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:87144306-87184045 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 46.76 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    238 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3609239
protein coding gene Chr9:87144224-87184051 (.)
129S1/SvImJ MGP_129S1SvImJ_G0035103
protein coding gene Chr9:88009483-88045958 (+)
A/J MGP_AJ_G0035084
protein coding gene Chr9:84916458-84954856 (+)
AKR/J MGP_AKRJ_G0035012
protein coding gene Chr9:86945398-86979021 (+)
BALB/cJ MGP_BALBcJ_G0035072
protein coding gene Chr9:84565579-84601510 (+)
C3H/HeJ MGP_C3HHeJ_G0034784
protein coding gene Chr9:87401553-87438283 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035596
protein coding gene Chr9:90378210-90413185 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032503
protein coding gene Chr9:83687936-83724017 (+)
CAST/EiJ MGP_CASTEiJ_G0034102
protein coding gene Chr9:87871077-87905157 (+)
CBA/J MGP_CBAJ_G0034757
protein coding gene Chr9:93539289-93567834 (+)
DBA/2J MGP_DBA2J_G0034915
protein coding gene Chr9:84474962-84507389 (+)
FVB/NJ MGP_FVBNJ_G0034858
protein coding gene Chr9:83561896-83596232 (+)
LP/J MGP_LPJ_G0034996
protein coding gene Chr9:88227422-88266693 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034900
protein coding gene Chr9:95187565-95230185 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035616
protein coding gene Chr9:87057940-87090826 (+)
PWK/PhJ MGP_PWKPhJ_G0033806
protein coding gene Chr9:84648320-84683809 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033642
protein coding gene Chr9:87246414-87282797 (+)
WSB/EiJ MGP_WSBEiJ_G0034219
protein coding gene Chr9:87090388-87125235 (+)



Homology
more
  • Human Ortholog
    MRAP2, melanocortin 2 receptor accessory protein 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MRAP2, melanocortin 2 receptor accessory protein 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    bA51G5.2, C6orf117
  • Links
    NCBI Gene ID: 112609
    neXtProt AC: NX_Q96G30
    UniProt: Q96G30

  • Chr Location
    6q14.2; chr6:84032621-84146278 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 16307
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: MRAP2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    30 phenotypes from 3 alleles in 3 genetic backgrounds
    1 phenotype from multigenic genotypes
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele develop severe obesity at a young age. Obesity develops early during ad libitum feeding before the onset of hyperphagia, persists in mutant mice pair-fed to a normal dietary intake, and is abolished only by underfeeding.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000042761 Ensembl Gene Model | MGI Sequence Detail 39740 C57BL/6J ±  kb
transcript ENSMUST00000049457 Ensembl | MGI Sequence Detail 1931 Not Applicable  
polypeptide ENSMUSP00000046271 Ensembl | MGI Sequence Detail 207 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 4
    cDNA 4

    Microarray probesets 2
References
more
  • Summaries
    All 28
    Gene Ontology 3
    Phenotypes 10
  • Earliest
    J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
  • Latest
    J:253492 Srisai D, et al., MRAP2 regulates ghrelin receptor signaling and hunger sensing. Nat Commun. 2017 Sep 28;8(1):713

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory