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Mrap2 Gene Detail
Summary
  • Symbol
    Mrap2
  • Name
    melanocortin 2 receptor accessory protein 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:3609239
    NCBI Gene: 244958
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:87026359-87066098 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 46.76 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1289 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3609239
 protein coding gene Chr9:87026293-87066104 (+)
129S1/SvImJ ENSMUSG00200005174
 protein coding gene Chr9:84151264-84184094 (+)
A/J ENSMUSG00195006977
 protein coding gene Chr9:83921547-83961135 (+)
AKR/J ENSMUSG00220019168
 protein coding gene Chr9:84046444-84086416 (+)
BALB/cJ ENSMUSG00180006676
 protein coding gene Chr9:84026430-84066028 (+)
C3H/HeJ ENSMUSG00175004386
 protein coding gene Chr9:84086022-84125619 (+)
C57BL/6NJ ENSMUSG00215007424
 protein coding gene Chr9:84032562-84072319 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032503
 protein coding gene Chr9:83687936-83724017 (+)
CAST/EiJ ENSTCUG00005003989
 protein coding gene Chr9:83615709-83648957 (+)
CBA/J ENSMUSG00210005745
 protein coding gene Chr9:84151915-84198859 (+)
DBA/2J ENSMUSG00185001774
 protein coding gene Chr9:84145675-84178313 (+)
FVB/NJ ENSMUSG00205004607
 protein coding gene Chr9:84327357-84360017 (+)
JF1/MsJ ENSUMUG00000019125
 protein coding gene Chr9:84041652-84074207 (+)
LP/J ENSMUSG00230007084
 protein coding gene Chr9:84282309-84315144 (+)
NOD/ShiLtJ ENSMUSG00190011186
 protein coding gene Chr9:84219971-84264077 (+)
NZO/HlLtJ ENSMUSG00225015903
 protein coding gene Chr9:84446629-84479280 (+)
PWK/PhJ ENSLUMG00010002857
 protein coding gene Chr9:83963786-83996604 (+)
SPRET/EiJ ENSMSPG00010002333
 protein coding gene Chr9:85424608-85456655 (+)
WSB/EiJ ENSIUOG00005003423
 protein coding gene Chr9:83622144-83654777 (+)



Homology
more
  • Human Ortholog
    MRAP2, melanocortin 2 receptor accessory protein 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MRAP2, melanocortin 2 receptor accessory protein 2
  • Synonyms
    bA51G5.2, C6orf117
  • Links
    NCBI Gene ID: 112609
    UniProt: Q96G30

  • Chr Location
    6q14.2; chr6:84033178-84146282 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    27 phenotypes from 3 alleles in 3 genetic backgrounds
    1 phenotype from multigenic genotypes
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele develop severe obesity at a young age. Obesity develops early during ad libitum feeding before the onset of hyperphagia, persists in mutant mice pair-fed to a normal dietary intake, and is abolished only by underfeeding.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    42
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    4
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000042761 Ensembl Gene Model | MGI Sequence Detail 39740 C57BL/6J ±  kb
    transcript ENSMUST00000113149 Ensembl | MGI Sequence Detail 2112 Not Applicable  
    polypeptide ENSMUSP00000108774 Ensembl | MGI Sequence Detail 207 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 4
      cDNA 4

      Microarray probesets 2
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 1
      Gene Ontology 6
      Phenotypes 17
    • Earliest
      J:146015 Sebag JA, et al., Regions of melanocortin 2 (MC2) receptor accessory protein necessary for dual topology and MC2 receptor trafficking and signaling. J Biol Chem. 2009 Jan 2;284(1):610-8
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory