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Mrap2
Gene Detail
 Symbol
Name
ID
Mrap2
melanocortin 2 receptor accessory protein 2
MGI:3609239
Feature Type protein coding gene
Genetic Map
Chromosome 9
46.76 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr9:87144306-87184045 bp, + strand
From VEGA annotation of GRCm38

  39740 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:16307  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Mrap2

Human
homologs
Human Homolog MRAP2, melanocortin 2 receptor accessory protein 2
NCBI Gene ID 112609
neXtProt AC  NX_Q96G30
Human Synonyms  bA51G5.2, BMIQ18, C6orf117
Human Chr (Location)  6q14.2; chr6:84023027-84090887 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele develop severe obesity at a young age. Obesity develops early during ad libitum feeding before the onset of hyperphagia, persists in mutant mice pair-fed to a normal dietary intake, and is abolished only by underfeeding.
 
Interactions
Mrap2 interacts with 164 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process energy homeostasis, energy reserve metabolic process, ...
Component endoplasmic reticulum, integral component of membrane, ...
Function corticotropin hormone receptor binding, type 1 melanocortin receptor binding, ...
Expression
cDNA source data(2)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(2) cDNA(2)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000024323 (Evidence)
Ensembl Gene ModelENSMUSG00000042761 (Evidence)
Entrez Gene244958 (Evidence)
UniGene335337
DFCITC1625603, TC1651863
DoTSDT.101712997, DT.110575045, DT.94164300
NIA Mouse Gene IndexU010829
Consensus CDS ProjectCCDS52878.1
International Mouse Knockout Project StatusMrap2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024323 VEGA Gene Model | MGI Sequence Detail 39740 C57BL/6J ±  kb
transcript OTTMUST00000059576 VEGA | MGI Sequence Detail 2112 Not Applicable 
polypeptide OTTMUSP00000028990 VEGA | MGI Sequence Detail 207 Not Applicable 

For the selected sequences
All sequences(50) RefSeq(20) UniProt(1)
Polymorphisms SNPs within 2kb(245 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
Protein Ontology PR:000010558 melanocortin-2 receptor accessory protein 2
References (Earliest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
(Latest) J:199365 Asai M, et al., Loss of function of the melanocortin 2 receptor accessory protein 2 is associated with mammalian obesity. Science. 2013 Jul 19;341(6143):275-8
All references(27)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory