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Mrap2 Gene Detail
Summary
  • Symbol
    Mrap2
  • Name
    melanocortin 2 receptor accessory protein 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:3609239
    NCBI Gene: 244958
  • Gene Overview
    MyGene.info: MRAP2
Location & Maps
more
  • Sequence Map
    Chr9:87144306-87184045 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      39740 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 46.76 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    MRAP2, melanocortin 2 receptor accessory protein 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MRAP2, melanocortin 2 receptor accessory protein 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    bA51G5.2, C6orf117
  • Links
    NCBI Gene ID: 112609
    neXtProt AC: NX_Q96G30

  • Chr Location
    6q14.2; chr6:84024786-84146282 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 16307
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: MRAP2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    31 phenotypes from 3 alleles in 3 genetic backgrounds
    1 phenotype from multigenic genotypes
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    1
  • Targeted
    5
  • Genomic Mutations
    1 involving Mrap2
  • Incidental Mutations
Mice homozygous for a knock-out allele develop severe obesity at a young age. Obesity develops early during ad libitum feeding before the onset of hyperphagia, persists in mutant mice pair-fed to a normal dietary intake, and is abolished only by underfeeding.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024323 VEGA Gene Model | MGI Sequence Detail 39740 C57BL/6J ±  kb
transcript OTTMUST00000059576 VEGA | MGI Sequence Detail 2112 Not Applicable  
polypeptide OTTMUSP00000028990 VEGA | MGI Sequence Detail 207 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    238 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 2
    cDNA 2

    Microarray probesets 2
References
more
  • Summaries
    All 24
    Gene Ontology 3
    Phenotypes 9
  • Earliest
    J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
  • Latest
    J:230718 Chaly AL, et al., The Melanocortin Receptor Accessory Protein 2 promotes food intake through inhibition of the Prokineticin Receptor-1. Elife. 2016;5

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory