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Gapt Gene Detail
Summary
  • Symbol
    Gapt
  • Name
    Grb2-binding adaptor, transmembrane
  • Synonyms
    9830130M13Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:3608341
    NCBI Gene: 238875
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:110352616-110357199 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 61.87 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    84 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3608341
protein coding gene Chr13:110352614-110357279 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020929
protein coding gene Chr13:112755305-112759850 (-)
A/J MGP_AJ_G0020879
protein coding gene Chr13:108307714-108312271 (-)
AKR/J MGP_AKRJ_G0020854
protein coding gene Chr13:111570430-111576300 (-)
BALB/cJ MGP_BALBcJ_G0020879
protein coding gene Chr13:109002946-109007653 (-)
C3H/HeJ MGP_C3HHeJ_G0020668
protein coding gene Chr13:111342826-111347408 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021314
protein coding gene Chr13:116138329-116142878 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018883
protein coding gene Chr13:103674727-103679310 (-)
CAST/EiJ MGP_CASTEiJ_G0020187
protein coding gene Chr13:110933214-110937764 (-)
CBA/J MGP_CBAJ_G0020630
protein coding gene Chr13:120595145-120599708 (-)
DBA/2J MGP_DBA2J_G0020753
protein coding gene Chr13:108023593-108028215 (-)
FVB/NJ MGP_FVBNJ_G0020736
protein coding gene Chr13:106700249-106704806 (-)
LP/J MGP_LPJ_G0020828
protein coding gene Chr13:112828290-112832821 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020764
protein coding gene Chr13:120985135-120990868 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021352
protein coding gene Chr13:111008418-111014068 (-)
PWK/PhJ MGP_PWKPhJ_G0019940
protein coding gene Chr13:106732353-106736938 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019762
protein coding gene Chr13:107279702-107284278 (-)
WSB/EiJ MGP_WSBEiJ_G0020245
protein coding gene Chr13:111588035-111592733 (-)



Homology
more
  • Human Ortholog
    GAPT, GRB2 binding adaptor protein, transmembrane
  • Vertebrate Orthologs
    7
  • Human Ortholog
    GAPT, GRB2 binding adaptor protein, transmembrane
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C5orf29
  • Links
    NCBI Gene ID: 202309
    neXtProt AC: NX_Q8N292
    UniProt: Q8N292

  • Chr Location
    5q11.2; chr5:58491435-58496358 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit increased B cell proliferation, marginal zone B cell numbers and concentrations of IgM, IgG2b and IgG3.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000046006 Ensembl Gene Model | MGI Sequence Detail 4584 C57BL/6J ±  kb
transcript ENSMUST00000058806 Ensembl | MGI Sequence Detail 2069 Not Applicable  
polypeptide ENSMUSP00000053775 Ensembl | MGI Sequence Detail 157 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 7
    cDNA 7

    Microarray probesets 1
References
more
  • Summaries
    All 22
    Gene Ontology 4
    Phenotypes 4
  • Earliest
    J:138146 Liu Y, et al., Identification of a new transmembrane adaptor protein that constitutively binds Grb2 in B cells. J Leukoc Biol. 2008 Sep;84(3):842-51
  • Latest
    J:237813 Chen JQ, et al., Abnormal Mammary Development in 129:STAT1-Null Mice is Stroma-Dependent. PLoS One. 2015;10(6):e0129895

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
05/14/2019
MGI 6.14
The Jackson Laboratory