Marchf11 MGI Mouse Gene Detail - MGI:3608327 - membrane associated ring-CH-type finger 11

Symbol

Marchf11
Name

membrane associated ring-CH-type finger 11
Synonyms

March11

Feature Type

protein coding gene
IDs

MGI:3608327
NCBI Gene: 211147
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr15:26309134-26409662 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 9.77 cM
Mapping Data

1 experiment

SNPs within 2kb

3062 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3608327	protein coding gene	Chr15:26309134-26409672 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021753	protein coding gene	Chr15:24321186-24426236 (+)
A/J	MGP_AJ_G0021713	protein coding gene	Chr15:23404599-23508666 (+)
AKR/J	MGP_AKRJ_G0021691	protein coding gene	Chr15:23931084-24033800 (+)
BALB/cJ	MGP_BALBcJ_G0021720	protein coding gene	Chr15:23374515-23475034 (+)
C3H/HeJ	MGP_C3HHeJ_G0021496	protein coding gene	Chr15:23974889-24082182 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022159	protein coding gene	Chr15:25373085-25478470 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019699	protein coding gene	Chr15:21708192-21822677 (+)
CAST/EiJ	MGP_CASTEiJ_G0021012	protein coding gene	Chr15:24324217-24440617 (+)
CBA/J	MGP_CBAJ_G0021465	protein coding gene	Chr15:26167083-26265653 (+)
DBA/2J	MGP_DBA2J_G0021589	protein coding gene	Chr15:23156673-23259386 (+)
FVB/NJ	MGP_FVBNJ_G0021567	protein coding gene	Chr15:22718167-22820255 (+)
LP/J	MGP_LPJ_G0021657	protein coding gene	Chr15:24188576-24304517 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021592	protein coding gene	Chr15:28867266-28990622 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022182	protein coding gene	Chr15:24131284-24237947 (+)
PWK/PhJ	MGP_PWKPhJ_G0020755	protein coding gene	Chr15:23315704-23419645 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020593	protein coding gene	Chr15:23942851-24052595 (+)
WSB/EiJ	MGP_WSBEiJ_G0021068	protein coding gene	Chr15:24118359-24227140 (+)

Human Ortholog

MARCHF11, membrane associated ring-CH-type finger 11

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MARCHF11, membrane associated ring-CH-type finger 11
Synonyms

MARCH11, MARCH-XI, RNF226
Links

HGNC:33609

NCBI Gene ID: 441061

UniProt: A6NNE9
Chr Location

5p15.1; chr5:16067139-16180762 (-) GRCh38

MGI Vertebrate Homology

Marchf11 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MARCHF11
Gene Tree

Marchf11

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
11 phenotype references

All Mutations and Alleles

6
Chemically induced (other)

2
Endonuclease-mediated

1
Gene trapped

2
Targeted

1
Genomic Mutations

2 involving Marchf11
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

22 strains or lines available

Male mice homozygous for a mutation are viable and show normal fertility.

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All GO Annotations

1
GO References

1

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.

Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

11

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase marchf11

ZFIN marchf11

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All Sequences

40
RefSeq

4
UniProt

2
CCDS

CCDS27401.2, CCDS79365.1

Ensembl

ENSMUSG00000022269 (Evidence)
NCBI Gene

211147

			Length	Strain/Species	Flank
genomic	ENSMUSG00000022269	Ensembl Gene Model \| MGI Sequence Detail	100529	C57BL/6J	± kb
transcript	ENSMUST00000140840	Ensembl \| MGI Sequence Detail	1558	Not Applicable
polypeptide	ENSMUSP00000118729	Ensembl \| MGI Sequence Detail	400	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000010175 E3 ubiquitin-protein ligase MARCHF11

(term hierarchy)
EC

2.3.2.27
InterPro Domains

IPR046356 E3 ubiquitin-protein ligase MARCHF4/9/11

IPR047906 MARCHF11, RING-CH finger C4HC3-type

IPR011016 Zinc finger, RING-CH-type

IPR013083 Zinc finger, RING/FYVE/PHD-type

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All nucleic 12

cDNA 12

Microarray probesets 4

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MGI:6368849

Summaries

All 31

Gene Ontology 1

Phenotypes 11
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:234235 Miyata H, et al., Genome engineering uncovers 54 evolutionarily conserved and testis-enriched genes that are not required for male fertility in mice. Proc Natl Acad Sci U S A. 2016 Jul 12;113(28):7704-10

TSS for Marchf11:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr130873	Chr15:26308877-26308886 (+)	-252 bp
Tssr130874	Chr15:26308947-26308961 (+)	-180 bp
Tssr130875	Chr15:26309106-26309112 (+)	-25 bp
Tssr130876	Chr15:26309125-26309141 (+)	-1 bp
Tssr130877	Chr15:26362286-26362287 (+)	53,153 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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