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Cdnf Gene Detail
Summary
  • Symbol
    Cdnf
  • Name
    cerebral dopamine neurotrophic factor
  • Synonyms
    Armetl1
  • Feature Type
    protein coding gene
  • IDs
    MGI:3606576
    NCBI Gene: 227526
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:3513065-3526376 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 1.99 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    52 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3606576
protein coding gene Chr2:3513030-3526376 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025311
protein coding gene Chr2:494866-508331 (+)
A/J MGP_AJ_G0025287
protein coding gene Chr2:463690-476961 (+)
AKR/J MGP_AKRJ_G0025256
protein coding gene Chr2:479637-492962 (+)
BALB/cJ MGP_BALBcJ_G0025283
protein coding gene Chr2:451598-464891 (+)
C3H/HeJ MGP_C3HHeJ_G0025043
protein coding gene Chr2:490065-506015 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025726
protein coding gene Chr2:483269-500212 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023140
protein coding gene Chr2:404066-418098 (+)
CAST/EiJ MGP_CASTEiJ_G0024507
protein coding gene Chr2:491343-513384 (+)
CBA/J MGP_CBAJ_G0025023
protein coding gene Chr2:522095-535426 (+)
DBA/2J MGP_DBA2J_G0025154
protein coding gene Chr2:444387-458205 (+)
FVB/NJ MGP_FVBNJ_G0025116
protein coding gene Chr2:456941-470746 (+)
LP/J MGP_LPJ_G0025241
protein coding gene Chr2:491281-504602 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025149
protein coding gene Chr2:486046-501883 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025784
protein coding gene Chr2:478075-491398 (+)
PWK/PhJ MGP_PWKPhJ_G0024256
protein coding gene Chr2:444944-458579 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024058
protein coding gene Chr2:498360-515373 (+)
WSB/EiJ MGP_WSBEiJ_G0024577
protein coding gene Chr2:488117-501941 (+)



Homology
more
  • Human Ortholog
    CDNF, cerebral dopamine neurotrophic factor
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CDNF, cerebral dopamine neurotrophic factor
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ARMETL1
  • Links
    NCBI Gene ID: 441549
    neXtProt AC: NX_Q49AH0
    UniProt: Q49AH0

  • Chr Location
    10p13; chr10:14819245-14838073 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 27965
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: CDNF
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 2 alleles in 2 genetic backgrounds
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit degeneration of enteric neurons, age-dependent enhanced amphetamine-induced hyperlocomotion, and altered dopamine neuronal function.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 227526 NCBI Gene Model | MGI Sequence Detail 13312 C57BL/6J ±  kb
    transcript NM_177647 RefSeq | MGI Sequence Detail 3013 C57BL/6  
    polypeptide Q8CC36 UniProt | EBI | MGI Sequence Detail 187 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 6
      cDNA 6

      Microarray probesets 1
    References
    more
    • Summaries
      All 21
      Developmental Gene Expression 2
      Gene Ontology 2
      Phenotypes 4
    • Earliest
      J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
    • Latest
      J:287361 Pakarinen E, et al., MANF Ablation Causes Prolonged Activation of the UPR without Neurodegeneration in the Mouse Midbrain Dopamine System. eNeuro. 2020 Jan/Feb;7(1)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    last database update
    07/07/2020
    MGI 6.15
    The Jackson Laboratory