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Btn2a2
Gene Detail
 Symbol
Name
ID
Btn2a2
butyrophilin, subfamily 2, member A2
MGI:3606486
Feature Type protein coding gene
Genetic Map
Chromosome 13
9.74 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr13:23477676-23488857 bp, - strand
From VEGA annotation of GRCm38

  11182 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56012  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: butyrophilin
Gene Tree: Btn2a2

Human
homologs
Human Homolog BTN2A2, butyrophilin, subfamily 2, member A2
NCBI Gene ID 10385
neXtProt AC  NX_Q8WVV5
Human Synonyms  BT2.2, BTF2, BTN2.2
Human Chr (Location)  6p22.1; chr6:26382870-26394874 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(4) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Btn2a2 interacts with 128 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process negative regulation of activated T cell proliferation, negative regulation of cellular metabolic process, ...
Component cell surface, extracellular vesicular exosome, ...
Function molecular_function
External Resources: FuncBase
Expression
cDNA source data(2)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(3) Genomic(1) cDNA(2)
Microarray probesets(1)
Other database
links
VEGA Gene ModelOTTMUSG00000000552 (Evidence)
Ensembl Gene ModelENSMUSG00000053216 (Evidence)
Entrez Gene238555 (Evidence)
UniGene129668
DFCITC1589870, TC1598615
DoTSDT.101710180, DT.94164259
NIA Mouse Gene IndexU165029
Consensus CDS ProjectCCDS36619.1
International Mouse Knockout Project StatusBtn2a2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000552 VEGA Gene Model | MGI Sequence Detail 11182 C57BL/6J ±  kb
transcript OTTMUST00000061660 VEGA | MGI Sequence Detail 2089 Not Applicable 
polypeptide OTTMUSP00000030287 VEGA | MGI Sequence Detail 514 Not Applicable 

For the selected sequences
All sequences(38) RefSeq(10) UniProt(3)
Polymorphisms SNPs within 2kb(84 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001870 B30.2/SPRY domain
InterPro IPR003879 Butyrophylin-like
InterPro IPR013162 CD80-like, immunoglobulin C2-set
InterPro IPR008985 Concanavalin A-like lectin/glucanases superfamily
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR013106 Immunoglobulin V-set
InterPro IPR003877 SPla/RYanodine receptor SPRY
InterPro IPR018355 SPla/RYanodine receptor subgroup
InterPro IPR006574 SPRY-associated
Protein Ontology PR:000032222 butyrophilin subfamily 2 member A2
References (Earliest) J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
(Latest) J:202549 Ammann JU, et al., Butyrophilin Btn2a2 inhibits TCR activation and phosphatidylinositol 3-kinase/Akt pathway signaling and induces Foxp3 expression in T lymphocytes. J Immunol. 2013 May 15;190(10):5030-6
All references(28)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory