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Btn2a2 Gene Detail
Summary
  • Symbol
    Btn2a2
  • Name
    butyrophilin, subfamily 2, member A2
  • Feature Type
    protein coding gene
  • IDs
    MGI:3606486
    NCBI Gene: 238555
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr13:23661846-23673027 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 9.74 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    84 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3606486
 protein coding gene Chr13:23661219-23673028 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020343
 protein coding gene Chr13:20883983-20896297 (-)
A/J MGP_AJ_G0020300
 protein coding gene Chr13:20514568-20525933 (-)
AKR/J MGP_AKRJ_G0020272
 protein coding gene Chr13:20754679-20765758 (-)
BALB/cJ MGP_BALBcJ_G0020286
 protein coding gene Chr13:20505313-20516560 (-)
C3H/HeJ MGP_C3HHeJ_G0020095
 protein coding gene Chr13:20837039-20848313 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020731
 protein coding gene Chr13:21625822-21659583 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018315
 protein coding gene Chr13:19316692-19329099 (-)
CAST/EiJ MGP_CASTEiJ_G0019617
 protein coding gene Chr13:20523849-20535290 (-)
CBA/J MGP_CBAJ_G0020046
 protein coding gene Chr13:22484685-22500602 (-)
DBA/2J MGP_DBA2J_G0020172
 protein coding gene Chr13:20084028-20095309 (-)
FVB/NJ MGP_FVBNJ_G0020160
 protein coding gene Chr13:19703333-19714524 (-)
LP/J MGP_LPJ_G0020245
 protein coding gene Chr13:21210103-21222833 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020190
 protein coding gene Chr13:22804025-22814966 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020761
 protein coding gene Chr13:20607413-20618594 (-)
PWK/PhJ MGP_PWKPhJ_G0019372
 protein coding gene Chr13:20072442-20083457 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019183
 protein coding gene Chr13:19409226-19422836 (-)
WSB/EiJ MGP_WSBEiJ_G0019673
 protein coding gene Chr13:20736429-20747652 (-)



Homology
more
  • Human Ortholog
    BTN2A1, butyrophilin subfamily 2 member A1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BTN2A1, butyrophilin subfamily 2 member A1
  • Synonyms
    BK14H9.1, BT2.1, BTF1, BTN2.1, DJ3E1.1
  • Links
    NCBI Gene ID: 11120
    neXtProt AC: NX_Q7KYR7
    UniProt: Q7KYR7

  • Chr Location
    6p22.2; chr6:26457904-26476622 (+)  GRCh38
  • Human Ortholog
    BTN2A2, butyrophilin subfamily 2 member A2
  • Synonyms
    BT2.2, BTF2, BTN2.2
  • Links
    NCBI Gene ID: 10385
    neXtProt AC: NX_Q8WVV5
    UniProt: Q8WVV5

  • Chr Location
    6p22.2; chr6:26383096-26394874 (+)  GRCh38
  • Human Ortholog
    BTN2A3P, butyrophilin subfamily 2 member A3, pseudogene
  • Synonyms
    BTN2.3, BTN2A3
  • Links
    NCBI Gene ID: 54718
    UniProt: Q96KV6

  • Chr Location
    6p22.2; chr6:26421391-26432383 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit enhanced effector CD4+ and CD8+ T cell responses, exacerbated experimental autoimmune encephalomyelitis, and anti-tumor immune responses.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000053216 Ensembl Gene Model | MGI Sequence Detail 11182 C57BL/6J ±  kb
    transcript ENSMUST00000110433 Ensembl | MGI Sequence Detail 2370 Not Applicable  
    polypeptide ENSMUSP00000106063 Ensembl | MGI Sequence Detail 514 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 4
      Genomic 2
      cDNA 2

      Microarray probesets 1
    References
    more
    • Summaries
      All 34
      Gene Ontology 3
      Phenotypes 20
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory