About   Help   FAQ
Btn2a2
Gene Detail
Symbol

Name
ID
Btn2a2
butyrophilin, subfamily 2, member A2
MGI:3606486
Feature Type
protein coding gene
Genetic Map
Chromosome 13
9.74 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr13:23477676-23488857 bp, - strand
From VEGA annotation of GRCm38

  11182 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56012  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: BTN2A2
Protein SuperFamily: butyrophilin
Gene Tree: Btn2a2

Human
homologs
BTN2A2, butyrophilin, subfamily 2, member A2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 10385
neXtProt AC: NX_Q8WVV5

Human Synonyms: BT2.2, BTF2, BTN2.2

Human Chr (Location): 6p22.1; chr6:26382886-26394874 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(4) Radiation induced(1) Targeted(3)
Genomic Mutations involving Btn2a2 (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
Interactions
Btn2a2 interacts with 127 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
Expression
cDNA source data(2)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase btn2a2    NEW 
Molecular
reagents
All nucleic(3) Genomic(1) cDNA(2)
Microarray probesets(1)
Other database
links
VEGA Gene Model OTTMUSG00000000552 (Evidence)
Ensembl Gene Model ENSMUSG00000053216 (Evidence)
Entrez Gene 238555 (Evidence)
UniGene 129668
DFCI TC1589870, TC1598615
DoTS DT.101710180, DT.94164259
NIA Mouse Gene Index U165029
Consensus CDS Project CCDS36619.1
International Mouse Phenotyping Consortium Status Btn2a2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000552 VEGA Gene Model | MGI Sequence Detail 11182 C57BL/6J ±  kb
transcript OTTMUST00000001139 VEGA | MGI Sequence Detail 2370 Not Applicable 
polypeptide OTTMUSP00000000520 VEGA | MGI Sequence Detail 514 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(12) UniProt(3)
Polymorphisms
SNPs within 2kb(84 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001870 B30.2/SPRY domain
InterPro IPR003879 Butyrophylin-like
InterPro IPR013162 CD80-like, immunoglobulin C2-set
InterPro IPR013320 Concanavalin A-like lectin/glucanase, subgroup
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR013106 Immunoglobulin V-set
InterPro IPR003877 SPla/RYanodine receptor SPRY
InterPro IPR006574 SPRY-associated
Protein Ontology PR:000032222 butyrophilin subfamily 2 member A2
References
(Earliest) J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
(Latest) J:202549 Ammann JU, et al., Butyrophilin Btn2a2 inhibits TCR activation and phosphatidylinositol 3-kinase/Akt pathway signaling and induces Foxp3 expression in T lymphocytes. J Immunol. 2013 May 15;190(10):5030-6
All references(26)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/18/2015
MGI 6.0
The Jackson Laboratory