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Nostrin Gene Detail
Summary
  • Symbol
    Nostrin
  • Name
    nitric oxide synthase trafficker
  • Synonyms
    Daip2, mDaIP2
  • Feature Type
    protein coding gene
  • IDs
    MGI:3606242
    NCBI Gene: 329416
Location & Maps
more
  • Sequence Map
    Chr2:69135800-69189330 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      53531 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 39.58 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    NOSTRIN, nitric oxide synthase trafficking
  • Vertebrate Orthologs
    9
  • Human Ortholog
    NOSTRIN, nitric oxide synthase trafficking
    Orthology source: HomoloGene
  • Synonyms
    DaIP2
  • Links
    NCBI Gene ID: 115677
    neXtProt AC: NX_Q8IVI9

  • Chr Location
    2q31.1; chr2:168786539-168865339 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    3
  • Chemically induced (other)
    1
  • Targeted
    2
  • Genomic Mutations
    1 involving Nostrin
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit impaired retinal vascular angiogenesis, endothelial cell proliferation, endothelial cell migration and induced neovascularization.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012971 VEGA Gene Model | MGI Sequence Detail 53531 C57BL/6J ±  kb
transcript OTTMUST00000031234 VEGA | MGI Sequence Detail 1808 Not Applicable  
polypeptide OTTMUSP00000013977 VEGA | MGI Sequence Detail 506 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    549 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 6
    cDNA 6

    Microarray probesets 2
References
more
  • Summaries
    All 19
    Developmental Gene Expression 1
    Gene Ontology 3
    Phenotypes 3
  • Earliest
    J:101502 Kim HW, et al., Mouse disabled 2 interacting protein 2 functions as a transcriptional repressor through direct binding onto its own promoter. Biochem Biophys Res Commun. 2005 Nov 11;337(1):75-81
  • Latest
    J:190524 Shalom-Barak T, et al., Placental PPARgamma regulates spatiotemporally diverse genes and a unique metabolic network. Dev Biol. 2012 Dec 1;372(1):143-55

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory