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Nostrin Gene Detail
Summary
  • Symbol
    Nostrin
  • Name
    nitric oxide synthase trafficker
  • Synonyms
    Daip2, mDaIP2
  • Feature Type
    protein coding gene
  • IDs
    MGI:3606242
    NCBI Gene: 329416
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:69135800-69189330 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 39.58 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    549 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3606242
protein coding gene Chr2:69135800-69189330 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025794
protein coding gene Chr2:69062529-69120361 (+)
A/J MGP_AJ_G0025771
protein coding gene Chr2:66406710-66463681 (+)
AKR/J MGP_AKRJ_G0025740
protein coding gene Chr2:68193911-68253515 (+)
BALB/cJ MGP_BALBcJ_G0025766
protein coding gene Chr2:66585668-66641982 (+)
C3H/HeJ MGP_C3HHeJ_G0025526
protein coding gene Chr2:68423150-68485752 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026213
protein coding gene Chr2:71150880-71215160 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023616
protein coding gene Chr2:63648277-63706702 (+)
CAST/EiJ MGP_CASTEiJ_G0024990
protein coding gene Chr2:68520449-68582046 (+)
CBA/J MGP_CBAJ_G0025506
protein coding gene Chr2:73748836-73810875 (+)
DBA/2J MGP_DBA2J_G0025637
protein coding gene Chr2:66048060-66107567 (+)
FVB/NJ MGP_FVBNJ_G0025600
protein coding gene Chr2:65423751-65481251 (+)
LP/J MGP_LPJ_G0025726
protein coding gene Chr2:68928089-68984395 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025629
protein coding gene Chr2:75817190-75877554 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026270
protein coding gene Chr2:68285383-68340240 (+)
PWK/PhJ MGP_PWKPhJ_G0024731
protein coding gene Chr2:65881740-65936660 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024538
protein coding gene Chr2:68512265-68571095 (+)
WSB/EiJ MGP_WSBEiJ_G0025058
protein coding gene Chr2:68702805-68762451 (+)



Homology
more
  • Human Ortholog
    NOSTRIN, nitric oxide synthase trafficking
  • Vertebrate Orthologs
    9
  • Human Ortholog
    NOSTRIN, nitric oxide synthase trafficking
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DaIP2
  • Links
    NCBI Gene ID: 115677
    neXtProt AC: NX_Q8IVI9
    UniProt: Q8IVI9

  • Chr Location
    2q24.3; chr2:168786539-168865339 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit impaired retinal vascular angiogenesis, endothelial cell proliferation, endothelial cell migration and induced neovascularization.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 329416 NCBI Gene Model | MGI Sequence Detail 53531 C57BL/6J ±  kb
transcript NM_181547 RefSeq | MGI Sequence Detail 1820 C57BL/6  
polypeptide Q6WKZ7 UniProt | EBI | MGI Sequence Detail 506 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
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  • All nucleic 7
    cDNA 7

    Microarray probesets 2
References
more
  • Summaries
    All 24
    Developmental Gene Expression 1
    Gene Ontology 3
    Phenotypes 4
  • Earliest
    J:101502 Kim HW, et al., Mouse disabled 2 interacting protein 2 functions as a transcriptional repressor through direct binding onto its own promoter. Biochem Biophys Res Commun. 2005 Nov 11;337(1):75-81
  • Latest
    J:242509 Chakraborty S, et al., Nitric-oxide synthase trafficking inducer is a pleiotropic regulator of endothelial cell function and signaling. J Biol Chem. 2017 Apr 21;292(16):6600-6620

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory