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Prss45
Gene Detail
Symbol

Name
ID
Prss45
protease, serine 45
MGI:3605764
Feature Type
protein coding gene
Genetic Map
Chromosome 9
60.79 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr9:110834588-110841313 bp, + strand
From VEGA annotation of GRCm38

  6726 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:51905  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: PRSS45
Protein SuperFamily: trypsin
Gene Tree: Prss45

Human
homologs
PRSS45, protease, serine, 45
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 377047
neXtProt AC: NX_Q7RTY3

Human Synonyms: TESSP5

Human Chr (Location): 3p21.31; chr3:46742091-46744755 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(4) Targeted(2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
Interactions
Prss45 interacts with 21 markers (Mir10a, Mir15a, Mir30b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (3 annotations)
Process proteolysis
Component extracellular region
Function serine-type endopeptidase activity
External Resources: FuncBase
Expression
cDNA source data(6)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(6) cDNA(6)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000034119 (Evidence)
Ensembl Gene Model ENSMUSG00000047257 (Evidence)
Entrez Gene 260408 (Evidence)
UniGene 79114
DFCI TC1587720
DoTS DT.110640855, DT.91418823
NIA Mouse Gene Index U056498
Consensus CDS Project CCDS23575.1
International Mouse Phenotyping Consortium Status Prss45
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034119 VEGA Gene Model | MGI Sequence Detail 6726 C57BL/6J ±  kb
transcript OTTMUST00000086320 VEGA | MGI Sequence Detail 1235 Not Applicable 
polypeptide OTTMUSP00000046725 VEGA | MGI Sequence Detail 317 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(107 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001254 Peptidase S1
InterPro IPR001314 Peptidase S1A, chymotrypsin-type
InterPro IPR018114 Peptidase S1, trypsin family, active site
InterPro IPR009003 Trypsin-like cysteine/serine peptidase domain
Protein Ontology PR:000031024 serine protease 45
References
(Earliest) J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(27)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory