Acaa1b
Gene Detail

Symbol Name ID

Acaa1b acetyl-Coenzyme A acyltransferase 1B MGI:3605455

Synonyms

thiolase B

Feature Type

protein coding gene

Genetic Map

Chromosome 9

71.33 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr9:119148023-119157093 bp, - strand From VEGA annotation of GRCm38   9071 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:129419  Vertebrate Homology Class
1 mouse

Protein SuperFamily: acetyl-CoA acetyltransferase
Gene Tree: Acaa1b

Alleles and phenotypes

All alleles(1) : Targeted(1)
 

Mice homozygous for a disruption in this gene appear normal.

 

Gene Ontology (GO) classifications

All GO classifications: (10 annotations)

Process	fatty acid metabolic process, lipid metabolic process, ...
Component	mitochondrion, peroxisome
Function	acetyl-CoA C-acyltransferase activity, catalytic activity, ...

Expression

Literature Summary: (5 records)
Data Summary: Results (303)    Tissues (216)    Images (38)
Theiler Stages: 17, 21, 23, 28

Assay Type	Results
RNA in situ	303

cDNA source data(131)
External Resources: GEO   ArrayExpress

Molecular reagents

All nucleic(132) cDNA(131) Primer pair(1)
Microarray probesets(2)

Other database links

VEGA Gene Model	OTTMUSG00000033525 (Evidence)
Ensembl Gene Model	ENSMUSG00000010651 (Evidence)
Entrez Gene	235674 (Evidence)
UniGene	379402
NIA Mouse Gene Index	U031422
EC	2.3.1.16
Consensus CDS Project	CCDS23608.1
International Mouse Knockout Project Status	Acaa1b

Sequences

Length	Strain/Species
genomic	OTTMUSG00000033525	VEGA Gene Model | MGI Sequence Detail	9071	C57BL/6J
transcript	OTTMUST00000084360	VEGA | MGI Sequence Detail	1689	Not Applicable
polypeptide	OTTMUSP00000045451	VEGA | MGI Sequence Detail	424	Not Applicable

All sequences(19) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(5 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002155	Thiolase
InterPro	IPR020610	Thiolase, active site
InterPro	IPR020615	Thiolase, acyl-enzyme intermediate active site
InterPro	IPR020613	Thiolase, conserved site
InterPro	IPR020617	Thiolase, C-terminal
InterPro	IPR016039	Thiolase-like
InterPro	IPR016038	Thiolase-like, subgroup
InterPro	IPR020616	Thiolase, N-terminal
Protein Ontology	PR:000004541	3-ketoacyl-CoA thiolase B, peroxisomal

References

(Earliest) J:105494 Chevillard G, et al., Targeted disruption of the peroxisomal thiolase B gene in mouse: a new model to study disorders related to peroxisomal lipid metabolism. Biochimie. 2004 Nov;86(11):849-56
(Latest) J:171615 Georgas KM, et al., Expression of metanephric nephron-patterning genes in differentiating mesonephric tubules. Dev Dyn. 2011 Jun;240(6):1600-12
All references(25)