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Acaa1b
Gene Detail
 Symbol
Name
ID
Acaa1b
acetyl-Coenzyme A acyltransferase 1B
MGI:3605455
Synonyms thiolase B
Feature Type protein coding gene
Genetic Map
Chromosome 9
71.33 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr9:119148023-119157093 bp, - strand
From VEGA annotation of GRCm38

  9071 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:91131  Vertebrate Homology Class
1 mouse

Protein SuperFamily: acetyl-CoA acetyltransferase
Gene Tree: Acaa1b

Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Spontaneous(1) Targeted(1)
Genomic Mutations involving Acaa1b (1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a disruption in this gene appear normal.
 
Interactions
Acaa1b interacts with 42 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process fatty acid metabolic process, lipid metabolic process, ...
Component mitochondrion, peroxisome
Function acetyl-CoA C-acyltransferase activity, catalytic activity, ...
Expression
Literature Summary: (5 records)
Data Summary: Results (317)    Tissues (231)    Images (38)
Theiler Stages: 17, 21, 23, 28
Assay TypeResults
RNA in situ 317
cDNA source data(131)
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(132) cDNA(131) Primer pair(1)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000033525 (Evidence)
Ensembl Gene ModelENSMUSG00000010651 (Evidence)
Entrez Gene235674 (Evidence)
UniGene379402
NIA Mouse Gene IndexU031422
EC2.3.1.16
Consensus CDS ProjectCCDS23608.1
International Mouse Knockout Project StatusAcaa1b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033525 VEGA Gene Model | MGI Sequence Detail 9071 C57BL/6J ±  kb
transcript OTTMUST00000084360 VEGA | MGI Sequence Detail 1689 Not Applicable 
polypeptide OTTMUSP00000045451 VEGA | MGI Sequence Detail 424 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(10) UniProt(3)
Polymorphisms SNPs within 2kb(84 from dbSNP Build 137)    SNPs within 2kb including multiple locations(98)
Protein-related
information
ResourceIDDescription
InterPro IPR002155 Thiolase
InterPro IPR020610 Thiolase, active site
InterPro IPR020615 Thiolase, acyl-enzyme intermediate active site
InterPro IPR020613 Thiolase, conserved site
InterPro IPR020617 Thiolase, C-terminal
InterPro IPR016039 Thiolase-like
InterPro IPR016038 Thiolase-like, subgroup
InterPro IPR020616 Thiolase, N-terminal
Protein Ontology PR:000004541 3-ketoacyl-CoA thiolase B, peroxisomal
References (Earliest) J:105494 Chevillard G, et al., Targeted disruption of the peroxisomal thiolase B gene in mouse: a new model to study disorders related to peroxisomal lipid metabolism. Biochimie. 2004 Nov;86(11):849-56
(Latest) J:171615 Georgas KM, et al., Expression of metanephric nephron-patterning genes in differentiating mesonephric tubules. Dev Dyn. 2011 Jun;240(6):1600-12
All references(25)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory