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Zmynd15 Gene Detail
Summary
  • Symbol
    Zmynd15
  • Name
    zinc finger, MYND-type containing 15
  • Feature Type
    protein coding gene
  • IDs
    MGI:3603821
    NCBI Gene: 574428
Location & Maps
more
  • Sequence Map
    Chr11:70459433-70466202 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      6770 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 42.99 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    ZMYND15, zinc finger MYND-type containing 15
  • Vertebrate Orthologs
    7
  • Human Ortholog
    ZMYND15, zinc finger MYND-type containing 15
    Orthology source: HomoloGene, HGNC
  • Synonyms
    SPGF14
  • Links
    NCBI Gene ID: 84225
    neXtProt AC: NX_Q9H091

  • Chr Location
    17p13.2; chr17:4740015-4746119 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human ZMYND15 associations

Human Disease Mouse Models
       Spermatogenic Failure 14; SPGF14   OMIM: 615842
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotype references
  • All Mutations and Alleles
    5
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • Targeted
    3
  • Genomic Mutations
    3 involving Zmynd15
  • Incidental Mutations
Mice homozygous for a knock-out allele of Cxcl16 and Zmynd15 exhibit abnormal spermiogenesis and reduced male fertility.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006043 VEGA Gene Model | MGI Sequence Detail 6770 C57BL/6J ±  kb
transcript OTTMUST00000013605 VEGA | MGI Sequence Detail 2804 Not Applicable  
polypeptide OTTMUSP00000006310 VEGA | MGI Sequence Detail 736 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    36 from dbSNP Build 142
Protein
Information
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  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000030687 zinc finger MYND domain-containing protein 15
  • InterPro Domains
    IPR002893 Zinc finger, MYND-type
Molecular
Reagents
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  • All nucleic 15
    cDNA 15

    Microarray probesets 1
References
more
  • Summaries
    All 18
    Developmental Gene Expression 1
    Gene Ontology 2
    Phenotypes 12
  • Earliest
    J:123851 Aslanian AM, et al., Targeted disruption of the scavenger receptor and chemokine CXCL16 accelerates atherosclerosis. Circulation. 2006 Aug 8;114(6):583-90
  • Latest
    J:166802 Yan W, et al., Zmynd15 encodes a histone deacetylase-dependent transcriptional repressor essential for spermiogenesis and male fertility. J Biol Chem. 2010 Oct 8;285(41):31418-26

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory