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Tctn1
Gene Detail
Symbol

Name
ID
Tctn1
tectonic family member 1
MGI:3603820
Synonyms
G730031O11Rik, Tect1
Feature Type
protein coding gene
Genetic Map
Chromosome 5
62.25 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr5:122241287-122264460 bp, - strand
From VEGA annotation of GRCm38

  23174 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:49770  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: TCTN1
Gene Tree: Tctn1

Human
homologs
TCTN1, tectonic family member 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 79600
neXtProt AC: NX_Q2MV58

Human Synonyms: JBTS13, TECT1

Human Chr (Location): 12q24.11; chr12:110614027-110649130 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human TCTN1

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(3) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a gene trapped allele exhibit embryonic lethality, holoprosencephaly and lack a neural floor plate.
 
Interactions
Tctn1 interacts with 99 markers (Mir17, Mir19a, Mir20a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process cell projection organization, central nervous system interneuron axonogenesis, ...
Component cell projection, ciliary transition zone, ...
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (19)    Tissues (11)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 2
In situ reporter (knock in) 14
RT-PCR 3
cDNA source data(5)
Other mouse links: GEO   Expression Atlas
Other vertebrate links: Xenbase tctn1    NEW 
Molecular
reagents
All nucleic(7) cDNA(5) Primer pair(1) Other(1)
Microarray probesets(1)
Other database
links
VEGA Gene Model OTTMUSG00000022563 (Evidence)
Ensembl Gene Model ENSMUSG00000038593 (Evidence)
Entrez Gene 654470 (Evidence)
Consensus CDS Project CCDS39254.1
International Mouse Phenotyping Consortium Status Tctn1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022563 VEGA Gene Model | MGI Sequence Detail 23174 C57BL/6J ±  kb
transcript OTTMUST00000054055 VEGA | MGI Sequence Detail 2278 Not Applicable 
polypeptide OTTMUSP00000025745 VEGA | MGI Sequence Detail 593 Not Applicable 

For the selected sequences
All sequences(37) RefSeq(5) UniProt(3)
Polymorphisms
SNPs within 2kb(16 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011677 Domain of unknown function DUF1619
Protein Ontology PR:000016209 tectonic-1
References
(Earliest) J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
(Latest) J:178978 Chih B, et al., A ciliopathy complex at the transition zone protects the cilia as a privileged membrane domain. Nat Cell Biol. 2011;14(1):61-72
All references(25)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory