Tctn1
Gene Detail

Symbol Name ID

Tctn1 tectonic family member 1 MGI:3603820

Synonyms

G730031O11Rik, Tect1

Feature Type

protein coding gene

Genetic Map

Chromosome 5

62.25 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr5:122241287-122264460 bp, - strand From VEGA annotation of GRCm38   23174 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:49770  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Gene Tree: Tctn1

Human homologs

Human Homolog		TCTN1, tectonic family member 1
NCBI Gene ID		79600
neXtProt AC		NX_Q2MV58
Human Synonyms		JBTS13, TECT1
Human Chr (Location)		12q24.11; chr12:111051832-111086935 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human TCTN1

Alleles and phenotypes

All alleles(7) : Targeted(4) Gene trapped(3)
 

Mice homozygous for a gene trapped allele exhibit embryonic lethality, holoprosencephaly and lack a neural floor plate.

 

Gene Ontology (GO) classifications

All GO classifications: (20 annotations)

Process	cell projection organization, central nervous system interneuron axonogenesis, ...
Component	cell projection, ciliary transition zone, ...
Function	protein binding

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (19)    Tissues (11)   
Theiler Stages: 10, 11, 12, 15, 19

Assay Type	Results
RNA in situ	2
In situ reporter (knock in)	14
RT-PCR	3

cDNA source data(5)
External Resources: GEO   ArrayExpress

Molecular reagents

All nucleic(7) cDNA(5) Primer pair(1) Other(1)
Microarray probesets(1)

Other database links

VEGA Gene Model	OTTMUSG00000022563 (Evidence)
Ensembl Gene Model	ENSMUSG00000038593 (Evidence)
Entrez Gene	654470 (Evidence)
DFCI	TC1585433, TC1596641
DoTS	DT.101364454, DT.110680742, DT.94253157
Consensus CDS Project	CCDS39254.1
International Mouse Knockout Project Status	Tctn1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000022563	VEGA Gene Model | MGI Sequence Detail	23174	C57BL/6J
transcript	OTTMUST00000054055	VEGA | MGI Sequence Detail	2278	Not Applicable
polypeptide	OTTMUSP00000025745	VEGA | MGI Sequence Detail	593	Not Applicable

All sequences(36) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(10 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR011677	Domain of unknown function DUF1619
Protein Ontology	PR:000016209	tectonic-1

References

(Earliest) J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
(Latest) J:178978 Chih B, et al., A ciliopathy complex at the transition zone protects the cilia as a privileged membrane domain. Nat Cell Biol. 2011;14(1):61-72
All references(29)