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Agpat9 Gene Detail
Summary
  • Symbol
    Agpat9
  • Name
    1-acylglycerol-3-phosphate O-acyltransferase 9
  • Synonyms
    4933407I02Rik, A230097K15Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:3603816
    NCBI Gene: 231510
  • Gene Overview
    MyGene.info: GPAT3
Location & Maps
more
  • Sequence Map
    Chr5:100845713-100899102 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      53390 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    GPAT3, glycerol-3-phosphate acyltransferase 3
  • Vertebrate Orthologs
    8
  • Human Ortholog
    GPAT3, glycerol-3-phosphate acyltransferase 3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    AGPAT10, AGPAT 10, AGPAT8, AGPAT9, HMFN0839, LPAAT-theta, MAG1
  • Links
    NCBI Gene ID: 84803
    neXtProt AC: NX_Q53EU6

  • Chr Location
    4q21.23; chr4:83535914-83605875 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    18 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Chemically induced (other)
    1
  • Gene trapped
    4
  • Radiation induced
    1
  • Spontaneous
    1
  • Targeted
    1
  • Genomic Mutations
    3 involving Agpat9
  • Incidental Mutations
    APF
Under high-fat feeding, mice homozygous for a knock-out allele exhibit increased energy expenditure, improved glucose homeostasis, enlarged livers, increased total serum cholesterol levels, altered liver cholesterol metabolism, and female-specific protection from diet-induced obesity.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026133 VEGA Gene Model | MGI Sequence Detail 53390 C57BL/6J ±  kb
transcript OTTMUST00000064542 VEGA | MGI Sequence Detail 3059 Not Applicable  
polypeptide OTTMUSP00000032074 VEGA | MGI Sequence Detail 438 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    548 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 9
    Genomic 1
    cDNA 8

    Microarray probesets 3
Other
Accession IDs
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MGI:1918298
References
more
  • Summaries
    All 28
    Developmental Gene Expression 1
    Gene Ontology 5
    Phenotypes 10
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:213618 Cao J, et al., Mice deleted for GPAT3 have reduced GPAT activity in white adipose tissue and altered energy and cholesterol homeostasis in diet-induced obesity. Am J Physiol Endocrinol Metab. 2014 May 15;306(10):E1176-87

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory