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Flrt2 Gene Detail
Summary
  • Symbol
    Flrt2
  • Name
    fibronectin leucine rich transmembrane protein 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:3603594
    NCBI Gene: 399558
  • Gene Overview
    MyGene.info: FLRT2
Location & Maps
more
  • Sequence Map
    Chr12:95692226-95785215 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      92990 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 46.44 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    FLRT2, fibronectin leucine rich transmembrane protein 2
  • Vertebrate Orthologs
    11
  • Human Ortholog
    FLRT2, fibronectin leucine rich transmembrane protein 2
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 23768
    neXtProt AC: NX_O43155

  • Chr Location
    14q31.3; chr14:85530105-85628696 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 8291
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: FLRT2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 2 alleles in 2 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    1
  • Targeted
    5
  • Genomic Mutations
    1 involving Flrt2
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit embryonic, fetal, and postnatel lethality with few mice surviving to weaning due to defects in epicardium, myocardium, and endocardium development.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017572 VEGA Gene Model | MGI Sequence Detail 92990 C57BL/6J ±  kb
transcript OTTMUST00000042733 VEGA | MGI Sequence Detail 7099 Not Applicable  
polypeptide OTTMUSP00000019193 VEGA | MGI Sequence Detail 660 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    801 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 90
    cDNA 89
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 35
    Developmental Gene Expression 12
    Gene Ontology 8
    Phenotypes 8
  • Earliest
    J:112631 Haines BP, et al., Regulated expression of FLRT genes implies a functional role in the regulation of FGF signalling during mouse development. Dev Biol. 2006 Sep 1;297(1):14-25
  • Latest
    J:224713 Jackson VA, et al., Structural basis of latrophilin-FLRT interaction. Structure. 2015 Apr 7;23(4):774-81

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory