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Flrt2 Gene Detail
Summary
  • Symbol
    Flrt2
  • Name
    fibronectin leucine rich transmembrane protein 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:3603594
    NCBI Gene: 399558
  • Gene Overview
    MyGene.info: FLRT2
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr12:95692226-95785215 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      92990 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 46.44 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    FLRT2, fibronectin leucine rich transmembrane protein 2
  • Vertebrate Orthologs
    11
  • Human Ortholog
    FLRT2, fibronectin leucine rich transmembrane protein 2
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 23768
    neXtProt AC: NX_O43155
    UniProt: O43155

  • Chr Location
    14q31.3; chr14:85530067-85628696 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 8291
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: FLRT2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 2 alleles in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit embryonic, fetal, and postnatel lethality with few mice surviving to weaning due to defects in epicardium, myocardium, and endocardium development.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000017572 VEGA Gene Model | MGI Sequence Detail 92990 C57BL/6J ±  kb
    transcript OTTMUST00000042734 VEGA | MGI Sequence Detail 3223 Not Applicable  
    polypeptide OTTMUSP00000019194 VEGA | MGI Sequence Detail 660 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      801 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 90
      cDNA 89
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 14
      Gene Ontology 7
      Phenotypes 10
    • Earliest
      J:112631 Haines BP, et al., Regulated expression of FLRT genes implies a functional role in the regulation of FGF signalling during mouse development. Dev Biol. 2006 Sep 1;297(1):14-25
    • Latest
      J:242901 Tai-Nagara I, et al., Placental labyrinth formation in mice requires endothelial FLRT2/UNC5B signaling. Development. 2017 Jul 01;144(13):2392-2401

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory