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Flrt2
Gene Detail
 Symbol
Name
ID
Flrt2
fibronectin leucine rich transmembrane protein 2
MGI:3603594
Feature Type protein coding gene
Genetic Map
Chromosome 12
46.44 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr12:95692226-95785215 bp, + strand
From VEGA annotation of GRCm38

  92990 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8291  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Gene Tree: Flrt2

Human
homologs
Human Homolog FLRT2, fibronectin leucine rich transmembrane protein 2
NCBI Gene ID 23768
neXtProt AC  NX_O43155
Human Chr (Location)  14q24-q32; chr14:85530067-85628696 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit embryonic, fetal, and postnatel lethality with few mice surviving to weaning due to defects in epicardium, myocardium, and endocardium development.
 
Interactions
Flrt2 interacts with 407 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process axon guidance, negative chemotaxis, ...
Component extracellular space, extracellular vesicular exosome, ...
Function chemorepellent activity, protein binding
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (101)    Tissues (82)    Images (49)
Theiler Stages: 11, 13, 15, 17, 18, 19, 20, 21, 22, 23, 27, 28
Assay TypeResults
RNA in situ 93
Northern blot 8
cDNA source data(88)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(90) cDNA(89) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000017572 (Evidence)
Ensembl Gene ModelENSMUSG00000047414 (Evidence)
Entrez Gene399558 (Evidence)
UniGene341948
DFCITC1582620, TC1598573
DoTSDT.484106, DT.60100972
Consensus CDS ProjectCCDS26094.1
International Mouse Knockout Project StatusFlrt2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017572 VEGA Gene Model | MGI Sequence Detail 92990 C57BL/6J ±  kb
transcript OTTMUST00000042733 VEGA | MGI Sequence Detail 7099 Not Applicable 
polypeptide OTTMUSP00000019193 VEGA | MGI Sequence Detail 660 Not Applicable 

For the selected sequences
All sequences(38) RefSeq(4) UniProt(3)
Polymorphisms SNPs within 2kb(801 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000483 Cysteine-rich flanking region, C-terminal
InterPro IPR003961 Fibronectin, type III
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR001611 Leucine-rich repeat
InterPro IPR000372 Leucine-rich repeat-containing N-terminal
InterPro IPR003591 Leucine-rich repeat, typical subtype
Protein Ontology PR:000007561 leucine-rich repeat transmembrane protein FLRT2
References (Earliest) J:112631 Haines BP, et al., Regulated expression of FLRT genes implies a functional role in the regulation of FGF signalling during mouse development. Dev Biol. 2006 Sep 1;297(1):14-25
(Latest) J:197638 van den Berghe V, et al., Directed migration of cortical interneurons depends on the cell-autonomous action of Sip1. Neuron. 2013 Jan 9;77(1):70-82
All references(34)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory