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Flrt2 Gene Detail
Summary
  • Symbol
    Flrt2
  • Name
    fibronectin leucine rich transmembrane protein 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:3603594
    NCBI Gene: 399558
  • Gene Overview
    MyGene.info: FLRT2
  • Alliance
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:95692226-95785215 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 46.44 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    801 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3603594
protein coding gene Chr12:95692039-95785215 (.)
129S1/SvImJ MGP_129S1SvImJ_G0020002
protein coding gene Chr12:96959830-97055025 (+)
A/J MGP_AJ_G0019957
protein coding gene Chr12:93270238-93364850 (+)
AKR/J MGP_AKRJ_G0019933
protein coding gene Chr12:95858348-95952018 (+)
BALB/cJ MGP_BALBcJ_G0019943
protein coding gene Chr12:93661921-93756640 (+)
C3H/HeJ MGP_C3HHeJ_G0019745
protein coding gene Chr12:96390968-96487803 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020392
protein coding gene Chr12:99872571-99975217 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018006
protein coding gene Chr12:90484228-90577545 (+)
CAST/EiJ MGP_CASTEiJ_G0019291
protein coding gene Chr12:91413128-91510983 (+)
CBA/J MGP_CBAJ_G0019717
protein coding gene Chr12:103628705-103730307 (+)
DBA/2J MGP_DBA2J_G0019828
protein coding gene Chr12:92745231-92841264 (+)
FVB/NJ MGP_FVBNJ_G0019817
protein coding gene Chr12:91530217-91626811 (+)
LP/J MGP_LPJ_G0019904
protein coding gene Chr12:96785135-96883736 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019859
protein coding gene Chr12:107001459-107099860 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020421
protein coding gene Chr12:95392986-95491152 (+)
PWK/PhJ MGP_PWKPhJ_G0019055
protein coding gene Chr12:87378194-87473443 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018851
protein coding gene Chr12:89585411-89688393 (+)
WSB/EiJ MGP_WSBEiJ_G0019345
protein coding gene Chr12:96245694-96341337 (+)



Homology
more
  • Human Ortholog
    FLRT2, fibronectin leucine rich transmembrane protein 2
  • Vertebrate Orthologs
    11
  • Human Ortholog
    FLRT2, fibronectin leucine rich transmembrane protein 2
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 23768
    neXtProt AC: NX_O43155
    UniProt: O43155

  • Chr Location
    14q31.3; chr14:85530067-85628696 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 8291
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: FLRT2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 2 alleles in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit embryonic, fetal, and postnatel lethality with few mice surviving to weaning due to defects in epicardium, myocardium, and endocardium development.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000047414 Ensembl Gene Model | MGI Sequence Detail 92990 C57BL/6J ±  kb
    transcript ENSMUST00000057324 Ensembl | MGI Sequence Detail 7099 Not Applicable  
    polypeptide ENSMUSP00000062171 Ensembl | MGI Sequence Detail 660 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 91
      cDNA 90
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 15
      Gene Ontology 6
      Phenotypes 11
    • Earliest
      J:112631 Haines BP, et al., Regulated expression of FLRT genes implies a functional role in the regulation of FGF signalling during mouse development. Dev Biol. 2006 Sep 1;297(1):14-25
    • Latest
      J:262848 Cicvaric A, et al., Enhanced synaptic plasticity and spatial memory in female but not male FLRT2-haplodeficient mice. Sci Rep. 2018 Feb 27;8(1):3703

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory