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Sgpp2 Gene Detail
Summary
  • Symbol
    Sgpp2
  • Name
    sphingosine-1-phosphate phosphotase 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:3589109
    NCBI Gene: 433323
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:78310345-78420289 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 40.23 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    855 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3589109
protein coding gene Chr1:78310044-78420289 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016197
protein coding gene Chr1:79027014-79141299 (+)
A/J MGP_AJ_G0016180
protein coding gene Chr1:76266171-76375996 (+)
AKR/J MGP_AKRJ_G0016137
protein coding gene Chr1:78314795-78431010 (+)
BALB/cJ MGP_BALBcJ_G0016135
protein coding gene Chr1:76343811-76454481 (+)
C3H/HeJ MGP_C3HHeJ_G0015966
protein coding gene Chr1:78700155-78813832 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016588
protein coding gene Chr1:82070565-82186552 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014309
protein coding gene Chr1:71700233-71809731 (+)
CAST/EiJ MGP_CASTEiJ_G0015550
protein coding gene Chr1:78072834-78187440 (+)
CBA/J MGP_CBAJ_G0015939
protein coding gene Chr1:84745444-84882503 (+)
DBA/2J MGP_DBA2J_G0016040
protein coding gene Chr1:75563844-75674083 (+)
FVB/NJ MGP_FVBNJ_G0016043
protein coding gene Chr1:74737235-74846507 (+)
LP/J MGP_LPJ_G0016112
protein coding gene Chr1:80164772-80279070 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016063
protein coding gene Chr1:88015211-88131161 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016635
protein coding gene Chr1:78462386-78575110 (+)
PWK/PhJ MGP_PWKPhJ_G0015337
protein coding gene Chr1:75036250-75148483 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015115
protein coding gene Chr1:77804359-77916445 (+)
WSB/EiJ MGP_WSBEiJ_G0015612
protein coding gene Chr1:78251245-78368867 (+)



Homology
more
  • Human Ortholog
    SGPP2, sphingosine-1-phosphate phosphatase 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SGPP2, sphingosine-1-phosphate phosphatase 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    SPP2, SPPase2
  • Links
    NCBI Gene ID: 130367
    neXtProt AC: NX_Q8IWX5
    UniProt: Q8IWX5

  • Chr Location
    2q36.1; chr2:222424052-222562622 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 51848
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: SGPP2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    1 images
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased pancreatic beta cell endoplasmic reticulum stress under basal conditions and decreased adaptive beta cell proliferation in response to treatment with either a high-fat diet or the beta cell-specific toxin, streptozotocin.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000032908 Ensembl Gene Model | MGI Sequence Detail 109945 C57BL/6J ±  kb
    transcript ENSMUST00000036172 Ensembl | MGI Sequence Detail 4002 Not Applicable  
    polypeptide ENSMUSP00000036656 Ensembl | MGI Sequence Detail 354 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 10
      cDNA 10

      Microarray probesets 3
    References
    more
    • Summaries
      All 27
      Developmental Gene Expression 4
      Gene Ontology 3
      Phenotypes 6
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:235035 Taguchi Y, et al., Sphingosine-1-phosphate Phosphatase 2 Regulates Pancreatic Islet beta-Cell Endoplasmic Reticulum Stress and Proliferation. J Biol Chem. 2016 Jun 3;291(23):12029-38

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    Funding Information
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    last database update
    07/09/2019
    MGI 6.14
    The Jackson Laboratory