Sgpp2 MGI Mouse Gene Detail - MGI:3589109 - sphingosine-1-phosphate phosphatase 2

Symbol

Sgpp2
Name

sphingosine-1-phosphate phosphatase 2

Feature Type

protein coding gene
IDs

MGI:3589109
NCBI Gene: 433323
Alliance

genome feature page
Transcription Start Sites

4 TSS

Sequence Map

Chr1:78286982-78396926 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 40.23 cM
Mapping Data

1 experiment

SNPs within 2kb

3097 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3589109	protein coding gene	Chr1:78286186-78396926 (+)
129S1/SvImJ	ENSMUSG00200033815	protein coding gene	Chr1:75968786-76077775 (+)
A/J	ENSMUSG00195008049	protein coding gene	Chr1:75378141-75487628 (+)
AKR/J	ENSMUSG00220010101	protein coding gene	Chr1:75529934-75639455 (+)
BALB/cJ	ENSMUSG00180015955	protein coding gene	Chr1:75640730-75750224 (+)
C3H/HeJ	ENSMUSG00175016686	protein coding gene	Chr1:75783028-75892516 (+)
C57BL/6NJ	ENSMUSG00215024686	protein coding gene	Chr1:75687988-75797934 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014309	protein coding gene	Chr1:71700233-71809731 (+)
CAST/EiJ	ENSTCUG00005028476	protein coding gene	Chr1:75386713-75496670 (+)
CBA/J	ENSMUSG00210040198	protein coding gene	Chr1:75499253-75620148 (+)
DBA/2J	ENSMUSG00185028069	protein coding gene	Chr1:76562655-76672600 (+)
FVB/NJ	ENSMUSG00205027446	protein coding gene	Chr1:75094614-75205173 (+)
JF1/MsJ	ENSUMUG00000005750	protein coding gene	Chr1:75435539-75545662 (+)
LP/J	ENSMUSG00230012182	protein coding gene	Chr1:76544382-76653365 (+)
NOD/ShiLtJ	ENSMUSG00190036042	protein coding gene	Chr1:75710378-75820336 (+)
NZO/HlLtJ	ENSMUSG00225038881	protein coding gene	Chr1:79763463-79872412 (+)
PWK/PhJ	ENSLUMG00010013521	protein coding gene	Chr1:75035607-75145824 (+)
SPRET/EiJ	ENSMSPG00010019353	protein coding gene	Chr1:77173155-77283958 (+)
WSB/EiJ	ENSIUOG00005013193	protein coding gene	Chr1:75300173-75417040 (+)

Human Ortholog

SGPP2, sphingosine-1-phosphate phosphatase 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SGPP2, sphingosine-1-phosphate phosphatase 2
Synonyms

SPP2, SPPase2
Links

HGNC:19953

NCBI Gene ID: 130367

UniProt: Q8IWX5
Chr Location

2q36.1; chr2:222423988-222562621 (+) GRCh38

MGI Vertebrate Homology

Sgpp2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SGPP2
Gene Tree

Sgpp2

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Phenotype Summary

9 phenotypes from 1 allele in 1 genetic background
1 images
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Chemically induced (other)

1
Radiation induced

1
Targeted

3
Genomic Mutations

2 involving Sgpp2
Incidental Mutations

APF
Find Mice (IMSR)

12 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit increased pancreatic beta cell endoplasmic reticulum stress under basal conditions and decreased adaptive beta cell proliferation in response to treatment with either a high-fat diet or the beta cell-specific toxin, streptozotocin.

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All GO Annotations

20
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

691
Tissues

94
cDNA Data

10
Literature Summary

5

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase sgpp2

ZFIN sgpp2

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All Sequences

48
RefSeq

12
UniProt

1
CCDS

CCDS15083.1

Ensembl

ENSMUSG00000032908 (Evidence)
NCBI Gene

433323

			Length	Strain/Species	Flank
genomic	ENSMUSG00000032908	Ensembl Gene Model \| MGI Sequence Detail	109945	C57BL/6J	± kb
transcript	ENSMUST00000036172	Ensembl \| MGI Sequence Detail	4002	Not Applicable
polypeptide	ENSMUSP00000036656	Ensembl \| MGI Sequence Detail	354	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000014802 sphingosine-1-phosphate phosphatase 2

(term hierarchy)
EC

3.1.3.-
InterPro Domains

IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase

IPR036938 Phosphatidic acid phosphatase type 2/haloperoxidase superfamily
GlyGen

Q810K3 1 site

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All nucleic 10

cDNA 10

Microarray probesets 3

Summaries

All 35

Developmental Gene Expression 5

Gene Ontology 8

Phenotypes 6
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:278511 Soldatov R, et al., Spatiotemporal structure of cell fate decisions in murine neural crest. Science. 2019 Jun 7;364(6444)

TSS for Sgpp2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr7567	Chr1:78286192-78286205 (+)	-783 bp
Tssr7568	Chr1:78286932-78287012 (+)	-10 bp
Tssr7569	Chr1:78287014-78287023 (+)	37 bp
Tssr7570	Chr1:78287028-78287037 (+)	51 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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