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Mrgprx2 Gene Detail
Summary
  • Symbol
    Mrgprx2
  • Name
    MAS-related GPR, member X2
  • Synonyms
    G370024M05Rik, MrgB10, Mrgprb10
  • Feature Type
    protein coding gene
  • IDs
    MGI:3588270
    NCBI Gene: 243978
  • Gene Overview
    MyGene.info: MRGPRX2
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr7:48478619-48499270 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 31.11 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    137 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3588270
protein coding gene Chr7:48478619-48499321 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032291
protein coding gene Chr7:49107321-49123898 (-)
A/J MGP_AJ_G0032270
protein coding gene Chr7:48384670-48399767 (-)
AKR/J MGP_AKRJ_G0032206
protein coding gene Chr7:49564025-49580630 (-)
BALB/cJ MGP_BALBcJ_G0032282
protein coding gene Chr7:48045300-48060955 (-)
C3H/HeJ MGP_C3HHeJ_G0031995
protein coding gene Chr7:49903424-49923018 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032775
protein coding gene Chr7:51354447-51374929 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029782
protein coding gene Chr7:51558056-51573777 (-)
CAST/EiJ MGP_CASTEiJ_G0031323
protein coding gene Chr7:41327712-41343565 (-)
CBA/J MGP_CBAJ_G0031960
protein coding gene Chr7:53114008-53138789 (-)
DBA/2J MGP_DBA2J_G0032117
protein coding gene Chr7:47603544-47618831 (-)
FVB/NJ MGP_FVBNJ_G0032071
protein coding gene Chr7:47553194-47568110 (-)
LP/J MGP_LPJ_G0032198
protein coding gene Chr7:50058593-50079232 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032108
protein coding gene Chr7:52236950-52256797 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032792
protein coding gene Chr7:48512856-48533207 (-)
PWK/PhJ MGP_PWKPhJ_G0031043
protein coding gene Chr7:40973164-40988839 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030884
protein coding gene Chr7:36677805-36697104 (-)
WSB/EiJ MGP_WSBEiJ_G0031441
protein coding gene Chr7:49203937-49219265 (-)



Homology
more
  • Human Ortholog
    MRGPRX2, MAS related GPR family member X2
  • Vertebrate Orthologs
    8
  • Human Ortholog
    MRGPRX2, MAS related GPR family member X2
    Orthology source: HomoloGene
  • Synonyms
    MGRG3, MRGX2
  • Links
    NCBI Gene ID: 117194
    neXtProt AC: NX_Q96LB1
    UniProt: Q96LB1

  • Chr Location
    11p15.1; chr11:19054455-19060681 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 243978 NCBI Gene Model | MGI Sequence Detail 20652 C57BL/6J ±  kb
transcript NM_001034868 RefSeq | MGI Sequence Detail 4559 C57BL/6  
polypeptide Q3UG50 UniProt | EBI | MGI Sequence Detail 352 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000001696 mas-related G-protein coupled receptor B10
  • InterPro Domains
    IPR019430 7TM GPCR, serpentine receptor class x (Srx)
    IPR017452 GPCR, rhodopsin-like, 7TM
    IPR000276 G protein-coupled receptor, rhodopsin-like
    IPR026234 Mas-related G protein-coupled receptor family
Molecular
Reagents
less
  • All nucleic 4
    cDNA 4

    Microarray probesets 1
Other
Accession IDs
less
MGI:3033187
References
more
  • Summaries
    All 22
    Gene Ontology 6
  • Earliest
    J:71586 Dong X, et al., A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons. Cell. 2001 Sep 7;106(5):619-32
  • Latest
    J:219209 McNeil BD, et al., Identification of a mast-cell-specific receptor crucial for pseudo-allergic drug reactions. Nature. 2015 Mar 12;519(7542):237-41

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory