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Gnat3 Gene Detail
Summary
  • Symbol
    Gnat3
  • Name
    guanine nucleotide binding protein, alpha transducing 3
  • Synonyms
    alpha-gustducin, Ggust, Gtn
  • Feature Type
    protein coding gene
  • IDs
    MGI:3588268
    NCBI Gene: 242851
  • Gene Overview
    MyGene.info: GNAT3
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr5:17962570-18019668 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 8.14 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    447 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3588268
protein coding gene Chr5:17962549-18019834 (.)
129S1/SvImJ MGP_129S1SvImJ_G0029307
protein coding gene Chr5:15356964-15425601 (+)
A/J MGP_AJ_G0029272
protein coding gene Chr5:14893921-14952297 (+)
AKR/J MGP_AKRJ_G0029223
protein coding gene Chr5:15507728-15572166 (+)
BALB/cJ MGP_BALBcJ_G0029284
protein coding gene Chr5:15324231-15383033 (+)
C3H/HeJ MGP_C3HHeJ_G0029003
protein coding gene Chr5:15529510-15588440 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029737
protein coding gene Chr5:16662959-16727114 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026976
protein coding gene Chr5:13164498-13220303 (+)
CAST/EiJ MGP_CASTEiJ_G0028415
protein coding gene Chr5:14865190-14928323 (+)
CBA/J MGP_CBAJ_G0028970
protein coding gene Chr5:16709023-16774361 (+)
DBA/2J MGP_DBA2J_G0029122
protein coding gene Chr5:15193785-15250745 (+)
FVB/NJ MGP_FVBNJ_G0029080
protein coding gene Chr5:14615876-14672877 (+)
LP/J MGP_LPJ_G0029206
protein coding gene Chr5:15788305-15846602 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029108
protein coding gene Chr5:17819456-17893884 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029770
protein coding gene Chr5:15160904-15221842 (+)
PWK/PhJ MGP_PWKPhJ_G0028137
protein coding gene Chr5:14230264-14292218 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027970
protein coding gene Chr5:14509341-14570125 (+)
WSB/EiJ MGP_WSBEiJ_G0028495
protein coding gene Chr5:15168688-15230444 (+)



Homology
more
  • Human Ortholog
    GNAT3, G protein subunit alpha transducin 3
  • Vertebrate Orthologs
    8
  • Human Ortholog
    GNAT3, G protein subunit alpha transducin 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GDCA
  • Links
    NCBI Gene ID: 346562
    neXtProt AC: NX_A8MTJ3
    UniProt: A8MTJ3

  • Chr Location
    7q21.11; chr7:80457291-80512503 (-)  GRCh38.p7

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    2 phenotypes from multigenic genotypes
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in abnormal taste sensitivity. Mice show reduced behavioral and electrophysiological responses to bitter, sweet, and unami compounds.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 242851 NCBI Gene Model | MGI Sequence Detail 57099 C57BL/6J ±  kb
    transcript NM_001081143 RefSeq | MGI Sequence Detail 1174 Not Specified  
    polypeptide Q3V3I2 UniProt | EBI | MGI Sequence Detail 354 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000008093 guanine nucleotide-binding protein G(t) subunit alpha-3
    • InterPro Domains
      IPR001408 G-protein alpha subunit, group I
      IPR011025 G protein alpha subunit, helical insertion
      IPR001019 Guanine nucleotide binding protein (G-protein), alpha subunit
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
    Molecular
    Reagents
    less
    • All nucleic 11
      Genomic 1
      cDNA 7
      Primer pair 2
      Other 1

      Microarray probesets 1
    Other
    Accession IDs
    less
    MGD-MRK-37040, MGI:108006
    References
    more
    • Summaries
      All 71
      Developmental Gene Expression 12
      Diseases 1
      Gene Ontology 12
      Phenotypes 30
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:262493 Lei W, et al., Activation of intestinal tuft cell-expressed Sucnr1 triggers type 2 immunity in the mouse small intestine. Proc Natl Acad Sci U S A. 2018 May 22;115(21):5552-5557

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory