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Gnat3
Gene Detail
Symbol

Name
ID
Gnat3
guanine nucleotide binding protein, alpha transducing 3
MGI:3588268
Synonyms
alpha-gustducin, Ggust, Gtn
Feature Type
protein coding gene
Genetic Map
Chromosome 5
8.14 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr5:17962570-18019668 bp, + strand
From NCBI annotation of GRCm38

  57099 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:24284  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

HCOP human homology predictions: GNAT3
Gene Tree: Gnat3

Human
homologs
GNAT3, guanine nucleotide binding protein, alpha transducing 3
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 346562
neXtProt AC: NX_A8MTJ3

Human Synonyms: GDCA

Human Chr (Location): 7q21.11; chr7:80457292-80527915 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous mutation of this gene results in abnormal taste sensitivity. Mice show reduced behavioral and electrophysiological responses to bitter, sweet, and unami compounds.
 
Interactions
Gnat3 interacts with 63 markers (Mir29a, Mir29b-1, Mir29b-2, ...)
Expression
Literature Summary: (11 records)
Data Summary: Results (18)    Tissues (9)    Images (12)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 7
RNA in situ 3
RT-PCR 8
cDNA source data(5)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(9) Genomic(1) cDNA(5) Primer pair(2) Other(1)
Microarray probesets(1)
Other database
links
Ensembl Gene Model ENSMUSG00000028777 (Evidence)
Entrez Gene 242851 (Evidence)
UniGene 332230
DoTS DT.91410847
NIA Mouse Gene Index U005314
Consensus CDS Project CCDS39017.1
International Mouse Phenotyping Consortium Status Gnat3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 242851 NCBI Gene Model | MGI Sequence Detail 57099 C57BL/6J ±  kb
transcript NM_001081143 RefSeq | MGI Sequence Detail 1174 Not Specified 
polypeptide Q3V3I2 UniProt | EBI | MGI Sequence Detail 354 Not Applicable 

For the selected sequences
All sequences(15) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(449 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001408 G-protein alpha subunit, group I
InterPro IPR011025 G protein alpha subunit, helical insertion
InterPro IPR001019 Guanine nucleotide binding protein (G-protein), alpha subunit
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000008093 guanine nucleotide-binding protein G(t) subunit alpha-3
Graphical View of Protein Domain Structure
References
(Earliest) J:36885 Wong GT, et al., Transduction of bitter and sweet taste by gustducin [see comments]. Nature. 1996 Jun 27;381(6585):796-800
(Latest) J:220916 Mokadem M, et al., Effects of Roux-en-Y gastric bypass on energy and glucose homeostasis are preserved in two mouse models of functional glucagon-like peptide-1 deficiency. Mol Metab. 2014 Apr;3(2):191-201
All references(56)
Other
accession IDs
MGD-MRK-37040, MGI:108006

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory