Tmem253 Gene Detail

Summary

• Symbol
  Tmem253
• Name
  transmembrane protein 253
• Synonyms
  G630016D24Rik

• Feature Type
  protein coding gene
• IDs
  MGI:3588246
  NCBI Gene: 619301

Location & Maps

• Sequence Map
  Chr14:52016865-52019787 bp, + strand
• From Ensembl annotation of GRCm38
  

  Mouse Genome Browser
  
  

• Download
  Sequence
    2923 bp   ±  kb flank
  
  
• Genome Browsers
  VEGA | Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 14, 26.77 cM
• Mapping Data
  1 experiment

Homology

• Human Ortholog
  TMEM253, transmembrane protein 253

• Vertebrate Orthologs
  6

• Human Ortholog
  TMEM253, transmembrane protein 253
  Orthology source: HomoloGene, HGNC
• Synonyms
  C14orf176, C14orf95, NCRNA00220
• Links
  HGNC:32545

  NCBI Gene ID: 643382

  neXtProt AC: NX_P0C7T8

  
  
• Chr Location
  14q11.2; chr14:21098937-21103724 (+)  GRCh38.p2

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• HomoloGene
  Vertebrate Homology Class 83921
  1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 dog
  
• HCOP
  human homology predictions: TMEM253
• Gene Tree
  Tmem253
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  6 phenotype references
  

• All Mutations and Alleles
  6
• Chemically induced (other)
  1
• Gene trapped
  4
• Targeted
  1
• Genomic Mutations
  1 involving Tmem253
• Incidental Mutations
  APF

Gene Ontology
(GO)
Classifications

• All GO Annotations
  2
• GO References
  1

Expression

• cDNA Data
  3

• Other Mouse Links
  Allen Institute
  GEO

Interactions

• Tmem253 interacts with 97 markers (Mir7b, Mir18, Mir18b, ...) View All

Sequences &
Gene Models

• All Sequences
  18
• RefSeq
  10
• UniProt
  1
• CCDS
  CCDS27049.1
• UniGene
  475177

• Ensembl
  ENSMUSG00000072571 (Evidence)
• NCBI Gene
  619301

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000072571	Ensembl Gene Model | MGI Sequence Detail	2923	C57BL/6J
transcript	ENSMUST00000100638	Ensembl | MGI Sequence Detail	1227	Not Applicable
polypeptide	ENSMUSP00000098203	Ensembl | MGI Sequence Detail	204	Not Applicable

Polymorphisms

• SNPs within 2kb
  31 from dbSNP Build 142

Protein
Information

• UniProt
  1 Sequence

Molecular
Reagents

• All nucleic 3

  cDNA 3

  
  

  Microarray probesets 1

References

• Summaries
  All 17

  Gene Ontology 1

  Phenotypes 6
• Earliest
  J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
• Latest
  J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42