Awat1 MGI Mouse Gene Detail - MGI:3588200 - acyl-CoA wax alcohol acyltransferase 1

Symbol

Awat1
Name

acyl-CoA wax alcohol acyltransferase 1
Synonyms

Dgat2l3

Feature Type

protein coding gene
IDs

MGI:3588200
NCBI Gene: 245533
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

ChrX:99615857-99621811 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome X, 43.72 cM
Mapping Data

1 experiment

SNPs within 2kb

13 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3588200	protein coding gene	ChrX:99615853-99621812 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0035943	protein coding gene	ChrX:97029769-97035723 (+)
A/J	MGP_AJ_G0035928	protein coding gene	ChrX:97072128-97078083 (+)
AKR/J	MGP_AKRJ_G0035844	protein coding gene	ChrX:99857006-99862961 (+)
BALB/cJ	MGP_BALBcJ_G0035911	protein coding gene	ChrX:95819423-95825378 (+)
C3H/HeJ	MGP_C3HHeJ_G0035620	protein coding gene	ChrX:97464124-97470079 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0036440	protein coding gene	ChrX:99941229-99947183 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0033270	protein coding gene	ChrX:94850964-94856911 (+)
CAST/EiJ	MGP_CASTEiJ_G0034907	protein coding gene	ChrX:81763846-81769786 (+)
CBA/J	MGP_CBAJ_G0035595	protein coding gene	ChrX:103036951-103042906 (+)
DBA/2J	MGP_DBA2J_G0035749	protein coding gene	ChrX:96279297-96285251 (+)
FVB/NJ	MGP_FVBNJ_G0035687	protein coding gene	ChrX:95679910-95685855 (+)
LP/J	MGP_LPJ_G0035839	protein coding gene	ChrX:98012582-98018536 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035722	protein coding gene	ChrX:107561224-107568506 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0036467	protein coding gene	ChrX:96747014-96752981 (+)
PWK/PhJ	MGP_PWKPhJ_G0034606	protein coding gene	ChrX:79385360-79391575 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0034434	protein coding gene	ChrX:82649059-82655072 (+)
WSB/EiJ	MGP_WSBEiJ_G0035046	protein coding gene	ChrX:95461195-95467167 (+)

Human Ortholog

AWAT1, acyl-CoA wax alcohol acyltransferase 1

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

AWAT1, acyl-CoA wax alcohol acyltransferase 1
Synonyms

DGA2, DGAT2L3
Links

HGNC:23252

NCBI Gene ID: 158833

neXtProt AC: NX_Q58HT5

UniProt: Q58HT5
Chr Location

Xq13.1; chrX:70234655-70240659 (+) GRCh38

MGI Vertebrate Homology

Awat1 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: AWAT1
Gene Tree

Awat1

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Phenotype Summary

6 phenotypes from 2 alleles in 2 genetic backgrounds
6 phenotypes from multigenic genotypes
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Endonuclease-mediated

3
Targeted

2
Incidental Mutations

APF
Find Mice (IMSR)

5 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit dry eyes associated with clogged meibomian gland orifice, reduced tear breakup time, and reduced production of (O-acyl)-omega-hydroxy fatty acids and tri-unsaturated species of 1 omega wax diesters.

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All GO Annotations

5
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

8
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase awat1

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All Sequences

30
RefSeq

2
UniProt

1
CCDS

CCDS41074.1

Ensembl

ENSMUSG00000015665 (Evidence)
NCBI Gene

245533

			Length	Strain/Species	Flank
genomic	ENSMUSG00000015665	Ensembl Gene Model \| MGI Sequence Detail	5955	C57BL/6J	± kb
transcript	ENSMUST00000096361	Ensembl \| MGI Sequence Detail	1390	Not Applicable
polypeptide	ENSMUSP00000094088	Ensembl \| MGI Sequence Detail	328	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000006434 acyl-CoA wax alcohol acyltransferase 1

(term hierarchy)
EC

2.3.1.75
InterPro Domains

IPR007130 Diacylglycerol acyltransferase

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All nucleic 8

cDNA 8

Microarray probesets 1

Summaries

All 25

Developmental Gene Expression 1

Gene Ontology 3

Phenotypes 7
Earliest

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
Latest

J:341496 Veniaminova NA, et al., Distinct mechanisms for sebaceous gland self-renewal and regeneration provide durability in response to injury. Cell Rep. 2023 Sep 26;42(9):113121

TSS for Awat1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr161612	ChrX:99615840-99615871 (+)	-1 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23