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Rtl4 Gene Detail
Summary
  • Symbol
    Rtl4
  • Name
    retrotransposon Gag like 4
  • Synonyms
    C230031A03Rik, Mar4, Zcchc16
  • Feature Type
    protein coding gene
  • IDs
    MGI:3588192
    NCBI Gene: 619287
  • Alliance
Location &
Maps
more
  • Sequence Map
    ChrX:144688907-145122411 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome X, 65.85 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1150 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3588192
protein coding gene ChrX:144688209-145122414 (+)
129S1/SvImJ MGP_129S1SvImJ_G0036160
protein coding gene ChrX:142249392-142680309 (+)
A/J MGP_AJ_G0036137
protein coding gene ChrX:141579585-142012021 (+)
AKR/J MGP_AKRJ_G0036063
protein coding gene ChrX:146183755-146635585 (+)
BALB/cJ MGP_BALBcJ_G0036128
protein coding gene ChrX:139815216-140219237 (+)
C3H/HeJ MGP_C3HHeJ_G0035836
protein coding gene ChrX:142367188-142798259 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036652
protein coding gene ChrX:146269500-146717568 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033475
protein coding gene ChrX:133494571-133514685 (+)
CAST/EiJ MGP_CASTEiJ_G0035127
protein coding gene ChrX:122991430-123392508 (+)
CBA/J MGP_CBAJ_G0035813
protein coding gene ChrX:150780389-151242098 (+)
DBA/2J MGP_DBA2J_G0035971
protein coding gene ChrX:140643168-141084218 (+)
FVB/NJ MGP_FVBNJ_G0035905
protein coding gene ChrX:139861643-140287047 (+)
LP/J MGP_LPJ_G0036062
protein coding gene ChrX:143206309-143632510 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035941
protein coding gene ChrX:158581096-159084617 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036688
protein coding gene ChrX:141555494-141960073 (+)
PWK/PhJ MGP_PWKPhJ_G0034821
protein coding gene ChrX:120130670-120151526 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034647
protein coding gene ChrX:123543087-123947398 (+)
WSB/EiJ MGP_WSBEiJ_G0035262
protein coding gene ChrX:139900079-140323736 (+)



Homology
more
  • Human Ortholog
    RTL4, retrotransposon Gag like 4
  • Vertebrate Orthologs
    6
  • Human Ortholog
    RTL4, retrotransposon Gag like 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    Mar4, Mart4, SIRH11, ZCCHC16
  • Links
    NCBI Gene ID: 340595
    neXtProt AC: NX_Q6ZR62
    UniProt: Q6ZR62

  • Chr Location
    Xq23; chrX:112083025-112457245 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 1 allele in 1 genetic background
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit abnormal behavior including hyperactivity and abnormal responses to a new environment, and abnormal working memory and cognition. Neuronal norepinephrine levesl are slow to recover after induced neurotransmitter release. Mortality, growth, kidney function, and reproductive system biology are all unaffected.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000071679 Ensembl Gene Model | MGI Sequence Detail 433505 C57BL/6J ±  kb
transcript ENSMUST00000112843 Ensembl | MGI Sequence Detail 3635 Not Applicable  
polypeptide ENSMUSP00000108462 Ensembl | MGI Sequence Detail 304 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
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  • All nucleic 6
    cDNA 5
    Primer pair 1

    Microarray probesets 1
References
more
  • Summaries
    All 22
    Developmental Gene Expression 2
    Gene Ontology 3
    Phenotypes 4
  • Earliest
    J:96508 Brandt J, et al., Transposable elements as a source of genetic innovation: expression and evolution of a family of retrotransposon-derived neogenes in mammals. Gene. 2005 Jan 17;345(1):101-11
  • Latest
    J:228903 Irie M, et al., Cognitive Function Related to the Sirh11/Zcchc16 Gene Acquired from an LTR Retrotransposon in Eutherians. PLoS Genet. 2015 Sep;11(9):e1005521

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
06/23/2020
MGI 6.15
The Jackson Laboratory