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Cdkl4
Gene Detail
 Symbol
Name
ID
Cdkl4
cyclin-dependent kinase-like 4
MGI:3587025
Synonyms LOC381113
Feature Type protein coding gene
Genetic Map
Chromosome 17
50.90 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr17:80523550-80563834 bp, - strand
From NCBI annotation of GRCm38

  40285 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:28725  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: kinase-related transforming protein
Gene Tree: Cdkl4

Human
homologs
Human Homolog CDKL4, cyclin-dependent kinase-like 4
NCBI Gene ID 344387
neXtProt AC  NX_Q5MAI5
Human Chr (Location)  2p22.1; chr2:39175995-39243973 (-)  GRCh38
Alleles
and
phenotypes
All alleles(5) : Targeted(2) Gene trapped(3)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process phosphorylation, protein phosphorylation
Component cytoplasm
Function ATP binding, cyclin-dependent protein serine/threonine kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (52)    Tissues (12)    Images (23)
Theiler Stages: 23
Assay TypeResults
RNA in situ 52
cDNA source data(13)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(13) cDNA(13)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000033966 (Evidence)
Entrez Gene381113 (Evidence)
UniGene329216
DFCITC1632085
DoTSDT.101343940, DT.60118165
NIA Mouse Gene IndexU038086, U323663
EC2.7.11.22
Consensus CDS ProjectCCDS28992.1
International Mouse Knockout Project StatusCdkl4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 381113 NCBI Gene Model | MGI Sequence Detail 40285 C57BL/6J ±  kb
transcript NM_001033443 RefSeq | MGI Sequence Detail 2931 Not Specified 
polypeptide Q3TZA2 UniProt | EBI | MGI Sequence Detail 342 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(16) UniProt(1)
Polymorphisms SNPs within 2kb(254 from dbSNP Build 137)    SNPs within 2kb including multiple locations(278)
Protein-related
information
ResourceIDDescription
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000005272 cyclin-dependent kinase-like 4
Graphical View of Protein Domain Structure
References (Earliest) J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(30)
Other
accession IDs
MGI:2147007, MGI:2685788

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory