Cdkl4
Gene Detail

Symbol Name ID

Cdkl4 cyclin-dependent kinase-like 4 MGI:3587025

Synonyms

LOC381113

Feature Type

protein coding gene

Genetic Map

Chromosome 17

50.90 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr17:80523550-80563834 bp, - strand From NCBI annotation of GRCm38   40285 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:28725  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: kinase-related transforming protein
Gene Tree: Cdkl4

Human homologs

Human Homolog		CDKL4, cyclin-dependent kinase-like 4
NCBI Gene ID		344387
neXtProt AC		NX_Q5MAI5
Human Chr (Location)		2p22.1; chr2:39405688-39456673 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(5) : Targeted(2) Gene trapped(3)

Gene Ontology (GO) classifications

All GO classifications: (13 annotations)

Process	phosphorylation, protein phosphorylation
Component	cytoplasm
Function	ATP binding, cyclin-dependent protein serine/threonine kinase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (52)    Tissues (12)    Images (23)
Theiler Stages: 23

Assay Type	Results
RNA in situ	52

cDNA source data(13)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(13) cDNA(13)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000033966 (Evidence)
Entrez Gene	381113 (Evidence)
UniGene	329216
DFCI	TC1632085
DoTS	DT.101343940, DT.60118165
NIA Mouse Gene Index	U038086, U323663
EC	2.7.11.22
Consensus CDS Project	CCDS28992.1
International Mouse Knockout Project Status	Cdkl4

Sequences

Length	Strain/Species
genomic	381113	NCBI Gene Model | MGI Sequence Detail	40285	C57BL/6J
transcript	NM_001033443	RefSeq | MGI Sequence Detail	2931	Not Specified
polypeptide	Q3TZA2	UniProt | EBI | MGI Sequence Detail	342	Not Applicable

All sequences(17) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(185 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR002290	Serine/threonine- / dual-specificity protein kinase, catalytic domain
InterPro	IPR008271	Serine/threonine-protein kinase, active site
Protein Ontology	PR:000005272	cyclin-dependent kinase-like 4

Graphical View of Protein Domain Structure

References

(Earliest) J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(30)

Other accession IDs

MGI:2147007, MGI:2685788