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Cdkl4
Gene Detail
Symbol

Name
ID
Cdkl4
cyclin-dependent kinase-like 4
MGI:3587025
Synonyms
LOC381113
Feature Type
protein coding gene
Genetic Map
Chromosome 17
50.90 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr17:80523550-80563834 bp, - strand
From Ensembl annotation of GRCm38

  40285 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:28725  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: CDKL4
Protein SuperFamily: kinase-related transforming protein
Gene Tree: Cdkl4

Human
homologs
CDKL4, cyclin-dependent kinase-like 4
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 344387
neXtProt AC: NX_Q5MAI5

Human Chr (Location): 2p22.1; chr2:39174937-39246810 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(3) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Cdkl4 interacts with 239 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process phosphorylation, protein phosphorylation
Component cytoplasm
Function ATP binding, cyclin-dependent protein serine/threonine kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (52)    Tissues (12)    Images (23)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 52
cDNA source data(13)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(13) cDNA(13)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000033966 (Evidence)
Entrez Gene 381113 (Evidence)
UniGene 329216
DFCI TC1632085
DoTS DT.60118165, DT.101343940
NIA Mouse Gene Index U323663, U038086
EC 2.7.11.22
Consensus CDS Project CCDS28992.1
International Mouse Phenotyping Consortium Status Cdkl4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000033966 Ensembl Gene Model | MGI Sequence Detail 40285 C57BL/6J ±  kb
transcript ENSMUST00000086545 Ensembl | MGI Sequence Detail 2931 Not Applicable 
polypeptide ENSMUSP00000083732 Ensembl | MGI Sequence Detail 342 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(16) UniProt(1)
Polymorphisms
SNPs within 2kb(254 from dbSNP Build 137)    SNPs within 2kb including multiple locations(278)
Protein-related
information
ResourceIDDescription
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000005272 cyclin-dependent kinase-like 4
References
(Earliest) J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(29)
Other
accession IDs
MGI:2147007, MGI:2685788

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory