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Lrp3 Gene Detail
Summary
  • Symbol
    Lrp3
  • Name
    low density lipoprotein receptor-related protein 3
  • Feature Type
    protein coding gene
  • IDs
    MGI:3584516
    NCBI Gene: 435965
  • Gene Overview
    MyGene.info: LRP3
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:35200027-35215498 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 21.15 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    96 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3584516
protein coding gene Chr7:35200027-35217392 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032084
protein coding gene Chr7:34558133-34574902 (-)
A/J MGP_AJ_G0032064
protein coding gene Chr7:33652346-33667833 (-)
AKR/J MGP_AKRJ_G0031997
protein coding gene Chr7:34452214-34467689 (-)
BALB/cJ MGP_BALBcJ_G0032071
protein coding gene Chr7:33944004-33959874 (-)
C3H/HeJ MGP_C3HHeJ_G0031788
protein coding gene Chr7:35352093-35367560 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032548
protein coding gene Chr7:36269001-36284532 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029581
protein coding gene Chr7:34371629-34386782 (-)
CAST/EiJ MGP_CASTEiJ_G0031123
protein coding gene Chr7:26494541-26578422 (-)
CBA/J MGP_CBAJ_G0031756
protein coding gene Chr7:37405801-37421272 (-)
DBA/2J MGP_DBA2J_G0031908
protein coding gene Chr7:33493239-33508707 (-)
FVB/NJ MGP_FVBNJ_G0031863
protein coding gene Chr7:33425345-33441686 (-)
LP/J MGP_LPJ_G0031985
protein coding gene Chr7:34893915-34910551 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031901
protein coding gene Chr7:36420477-36437633 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032563
protein coding gene Chr7:33998419-34014084 (-)
PWK/PhJ MGP_PWKPhJ_G0030845
protein coding gene Chr7:26825072-26905229 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030680
protein coding gene Chr7:23575469-23590404 (-)
WSB/EiJ MGP_WSBEiJ_G0031233
protein coding gene Chr7:34545263-34560728 (-)



Homology
more
  • Human Ortholog
    LRP3, LDL receptor related protein 3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    LRP3, LDL receptor related protein 3
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 4037
    neXtProt AC: NX_O75074
    UniProt: O75074

  • Chr Location
    19q13.11; chr19:33194693-33208867 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 1745
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: LRP3
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • cDNA Data
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000001802 Ensembl Gene Model | MGI Sequence Detail 15472 C57BL/6J ±  kb
transcript ENSMUST00000122409 Ensembl | MGI Sequence Detail 4147 Not Applicable  
polypeptide ENSMUSP00000114026 Ensembl | MGI Sequence Detail 790 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    5 Sequences
  • InterPro Domains
    IPR000859 CUB domain
    IPR036055 LDL receptor-like superfamily
    IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved site
    IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
    IPR035914 Spermadhesin, CUB domain superfamily
Molecular
Reagents
less
  • All nucleic 6
    cDNA 6

    Microarray probesets 1
References
more
  • Summaries
    All 20
    Gene Ontology 2
    Phenotypes 4
  • Earliest
    J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
05/26/2020
MGI 6.15
The Jackson Laboratory