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Gpr17 Gene Detail
Summary
  • Symbol
    Gpr17
  • Name
    G protein-coupled receptor 17
  • Feature Type
    protein coding gene
  • IDs
    MGI:3584514
    NCBI Gene: 574402
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:32076050-32082689 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 17.89 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    269 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3584514
 protein coding gene Chr18:32076050-32082925 (-)
129S1/SvImJ ENSMUSG00200016246
 protein coding gene Chr18:29074357-29080996 (-)
A/J ENSMUSG00195002365
 protein coding gene Chr18:29265408-29272047 (-)
AKR/J ENSMUSG00220011249
 protein coding gene Chr18:29223153-29229799 (-)
BALB/cJ ENSMUSG00180003480
 protein coding gene Chr18:29730602-29737249 (-)
C3H/HeJ ENSMUSG00175023387
 protein coding gene Chr18:29245895-29252541 (-)
C57BL/6NJ ENSMUSG00215017917
 protein coding gene Chr18:28946573-28953212 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022070
 protein coding gene Chr18:29298389-29305050 (-)
CAST/EiJ ENSTCUG00005015547
 protein coding gene Chr18:28876457-28883105 (-)
CBA/J ENSMUSG00210015758
 protein coding gene Chr18:29264337-29270976 (-)
DBA/2J ENSMUSG00185022463
 protein coding gene Chr18:29198935-29205574 (-)
FVB/NJ ENSMUSG00205017513
 protein coding gene Chr18:28932674-28939320 (-)
JF1/MsJ ENSUMUG00000015820
 protein coding gene Chr18:29323980-29330625 (-)
LP/J ENSMUSG00230043790
 protein coding gene Chr18:31271974-31278613 (-)
NOD/ShiLtJ ENSMUSG00190006621
 protein coding gene Chr18:28992942-28999581 (-)
NZO/HlLtJ ENSMUSG00225045105
 protein coding gene Chr18:31196481-31203120 (-)
PWK/PhJ ENSLUMG00010003037
 protein coding gene Chr18:29471727-29478374 (-)
SPRET/EiJ ENSMSPG00010021399
 protein coding gene Chr18:29500079-29503582 (-)
WSB/EiJ ENSIUOG00005002688
 protein coding gene Chr18:29004335-29010957 (-)



Homology
more
  • Human Ortholog
    GPR17, G protein-coupled receptor 17
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GPR17, G protein-coupled receptor 17
  • Links
    NCBI Gene ID: 2840
    UniProt: Q13304

  • Chr Location
    2q14.3; chr2:127645864-127656181 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 5 alleles in 5 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit early differentiation of oligodendroglial progenitor cells and increased myelination without any behavioral or motor deficits. Homozygotes for a different null allele show increased vascular permeability in IgE-dependent passive cutaneous anaphylaxis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    13
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    641
  • Tissues
    17
  • cDNA Data
    19
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000052229 Ensembl Gene Model | MGI Sequence Detail 6640 C57BL/6J ±  kb
    transcript ENSMUST00000064016 Ensembl | MGI Sequence Detail 5195 Not Applicable  
    polypeptide ENSMUSP00000063670 Ensembl | MGI Sequence Detail 339 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 20
      cDNA 19
      Primer pair 1
      Antibodies 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:2147281
    References
    more
    • Summaries
      All 57
      Developmental Gene Expression 6
      Gene Ontology 7
      Phenotypes 17
    • Earliest
      J:83410 Vassilatis DK, et al., The G protein-coupled receptor repertoires of human and mouse. Proc Natl Acad Sci U S A. 2003 Apr 15;100(8):4903-8
    • Latest
      J:359856 Xu X, et al., Nzf2 promotes oligodendrocyte differentiation and regeneration via repressing HDAC1-mediated histone deacetylation. Sci Adv. 2024 Dec 13;10(50):eadf8405
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory