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Gpr17 Gene Detail
Summary
  • Symbol
    Gpr17
  • Name
    G protein-coupled receptor 17
  • Feature Type
    protein coding gene
  • IDs
    MGI:3584514
    NCBI Gene: 574402
  • Gene Overview
    MyGene.info: GPR17
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:31942997-31949636 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 17.89 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    59 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3584514
protein coding gene Chr18:31942997-31949902 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024221
protein coding gene Chr18:30073645-30080284 (-)
A/J MGP_AJ_G0024187
protein coding gene Chr18:29070710-29077349 (-)
AKR/J MGP_AKRJ_G0024156
protein coding gene Chr18:29873162-29879808 (-)
BALB/cJ MGP_BALBcJ_G0024187
protein coding gene Chr18:29163621-29170267 (-)
C3H/HeJ MGP_C3HHeJ_G0023955
protein coding gene Chr18:29911966-29918612 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024629
protein coding gene Chr18:31139883-31146522 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022070
protein coding gene Chr18:29298389-29305050 (-)
CAST/EiJ MGP_CASTEiJ_G0023430
protein coding gene Chr18:29807468-29814116 (-)
CBA/J MGP_CBAJ_G0023923
protein coding gene Chr18:32102012-32108651 (-)
DBA/2J MGP_DBA2J_G0024055
protein coding gene Chr18:28744461-28751100 (-)
FVB/NJ MGP_FVBNJ_G0024021
protein coding gene Chr18:28447821-28454467 (-)
LP/J MGP_LPJ_G0024136
protein coding gene Chr18:30152260-30158899 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024049
protein coding gene Chr18:33448660-33455299 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024677
protein coding gene Chr18:29741669-29748308 (-)
PWK/PhJ MGP_PWKPhJ_G0023173
protein coding gene Chr18:28902917-28909564 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022982
protein coding gene Chr18:29970907-29977547 (-)
WSB/EiJ MGP_WSBEiJ_G0023493
protein coding gene Chr18:29642068-29648690 (-)



Homology
more
  • Human Ortholog
    GPR17, G protein-coupled receptor 17
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GPR17, G protein-coupled receptor 17
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 2840
    neXtProt AC: NX_Q13304
    UniProt: Q13304

  • Chr Location
    2q14.3; chr2:127645864-127652639 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 4 alleles in 4 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit early differentiation of oligodendroglial progenitor cells and increased myelination without any behavioral or motor deficits. Homozygotes for a different null allele show increased vascular permeability in IgE-dependent passive cutaneous anaphylaxis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000052229 Ensembl Gene Model | MGI Sequence Detail 6640 C57BL/6J ±  kb
    transcript ENSMUST00000064016 Ensembl | MGI Sequence Detail 5195 Not Applicable  
    polypeptide ENSMUSP00000063670 Ensembl | MGI Sequence Detail 339 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 19

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:2147281
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 4
      Gene Ontology 7
      Phenotypes 11
    • Earliest
      J:83410 Vassilatis DK, et al., The G protein-coupled receptor repertoires of human and mouse. Proc Natl Acad Sci U S A. 2003 Apr 15;100(8):4903-8
    • Latest
      J:258717 Coppolino GT, et al., Differential local tissue permissiveness influences the final fate of GPR17-expressing oligodendrocyte precursors in two distinct models of demyelination. Glia. 2018 May;66(5):1118-1130

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory