Kcnh5
Gene Detail

Symbol Name ID

Kcnh5 potassium voltage-gated channel, subfamily H (eag-related), member 5 MGI:3584508

Feature Type

protein coding gene

Genetic Map

Chromosome 12

32.62 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr12:74897217-75177332 bp, - strand From NCBI annotation of GRCm38   280116 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Kcnh5 ± 2 cM)

Protein SuperFamily: potassium voltage-gated channel, subfamily H
Gene Tree: Kcnh5

Human ortholog

KCNH5 potassium voltage-gated channel, subfamily H (eag-related), member 5 NCBI Gene ID 27133
Human Synonyms: EAG2, H-EAG2, Kv10.2
Human Chr14:63173945-63568584 bp, - strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(5) : Targeted(5)
 

Mice homozygous for a targeted gene disruption display thigmotaxis and abnormal startle reflex.

 

Gene Ontology (GO) classifications

All GO classifications: (26 annotations)

Process	ion transport, phosphorelay signal transduction system, ...
Component	cell surface, integral to membrane, ...
Function	calmodulin binding, ion channel activity, ...

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (141)    Tissues (87)    Images (33)
Theiler Stages: 19, 23, 28

Assay Type	Results
RNA in situ	42
In situ reporter (knock in)	61
RT-PCR	38

cDNA source data(4)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(5) cDNA(4) Primer pair(1)
Microarray probesets(1)

Other database links

Ensembl Gene Model	ENSMUSG00000034402 (Evidence)
Entrez Gene	238271 (Evidence)
UniGene	44465
DFCI	TC1588622
DoTS	DT.99847399
NIA Mouse Gene Index	U034076
Consensus CDS Project	CCDS25980.1
International Mouse Knockout Project Status	Kcnh5

Sequences

Length	Strain/Species
genomic	238271	NCBI Gene Model | MGI Sequence Detail	280116	C57BL/6J
transcript	NM_172805	RefSeq | MGI Sequence Detail	4061	C57BL/6
polypeptide	Q920E3	UniProt | EBI | MGI Sequence Detail	988	Not Applicable

All sequences(14) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(1328 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000595	Cyclic nucleotide-binding domain
InterPro	IPR018490	Cyclic nucleotide-binding-like
InterPro	IPR005821	Ion transport domain
InterPro	IPR001610	PAC motif
InterPro	IPR000700	PAS-associated, C-terminal
InterPro	IPR000014	PAS domain
InterPro	IPR003949	Potassium channel, voltage-dependent, EAG
InterPro	IPR003938	Potassium channel, voltage-dependent, EAG/ELK/ERG
InterPro	IPR014710	RmlC-like jelly roll fold
Protein Ontology	PR:000000794	voltage-gated potassium channel KCNH5

Graphical View of Protein Domain Structure

References

(Earliest) J:104881 The RIKEN BioResource Center, Information obtained from The RIKEN BioResource Center. Unpublished. 2006-2010;
(Latest) J:186629 Huang X, et al., Voltage-gated potassium channel EAG2 controls mitotic entry and tumor growth in medulloblastoma via regulating cell volume dynamics. Genes Dev. 2012 Aug 15;26(16):1780-96
All references(28)