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Kcnh5
Gene Detail
 Symbol
Name
ID
Kcnh5
potassium voltage-gated channel, subfamily H (eag-related), member 5
MGI:3584508
Feature Type protein coding gene
Genetic Map
Chromosome 12
32.62 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr12:74897217-75177332 bp, - strand
From NCBI annotation of GRCm38

  280116 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:15858  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: potassium voltage-gated channel, subfamily H
Gene Tree: Kcnh5

Human
homologs
Human Homolog KCNH5, potassium voltage-gated channel, subfamily H (eag-related), member 5
NCBI Gene ID 27133
neXtProt AC  NX_Q8NCM2
Human Synonyms  EAG2, hEAG2, H-EAG2, Kv10.2
Human Chr (Location)  14q23.2; chr14:62706573-63045238 (-)  GRCh38
Alleles
and
phenotypes
All alleles(5) : Targeted(5)
 
Mice homozygous for a targeted gene disruption display thigmotaxis and abnormal startle reflex.
 
Gene Ontology
(GO)
classifications
All GO classifications: (25 annotations)
Process ion transport, phosphorelay signal transduction system, ...
Component cell surface, integral component of membrane, ...
Function calmodulin binding, ion channel activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (141)    Tissues (87)    Images (33)
Theiler Stages: 19, 23, 28
Assay TypeResults
RNA in situ 42
In situ reporter (knock in) 61
RT-PCR 38
cDNA source data(4)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(5) cDNA(4) Primer pair(1)
Microarray probesets(1)
Other database
links
Ensembl Gene ModelENSMUSG00000034402 (Evidence)
Entrez Gene238271 (Evidence)
UniGene44465
DFCITC1588622
DoTSDT.99847399
NIA Mouse Gene IndexU034076
Consensus CDS ProjectCCDS25980.1
International Mouse Knockout Project StatusKcnh5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 238271 NCBI Gene Model | MGI Sequence Detail 280116 C57BL/6J ±  kb
transcript NM_172805 RefSeq | MGI Sequence Detail 4061 C57BL/6 
polypeptide Q920E3 UniProt | EBI | MGI Sequence Detail 988 Not Applicable 

For the selected sequences
All sequences(14) RefSeq(2) UniProt(2)
Polymorphisms SNPs within 2kb(1731 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000595 Cyclic nucleotide-binding domain
InterPro IPR018490 Cyclic nucleotide-binding-like
InterPro IPR005821 Ion transport domain
InterPro IPR001610 PAC motif
InterPro IPR000700 PAS-associated, C-terminal
InterPro IPR000014 PAS domain
InterPro IPR003949 Potassium channel, voltage-dependent, EAG
InterPro IPR003938 Potassium channel, voltage-dependent, EAG/ELK/ERG
InterPro IPR014710 RmlC-like jelly roll fold
Protein Ontology PR:000000794 voltage-gated potassium channel KCNH5
Graphical View of Protein Domain Structure
References (Earliest) J:104881 The RIKEN BioResource Center, Information obtained from The RIKEN BioResource Center. Unpublished. 2006-2013;
(Latest) J:186629 Huang X, et al., Voltage-gated potassium channel EAG2 controls mitotic entry and tumor growth in medulloblastoma via regulating cell volume dynamics. Genes Dev. 2012 Aug 15;26(16):1780-96
All references(29)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory