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Wdr72 Gene Detail
Summary
  • Symbol
    Wdr72
  • Name
    WD repeat domain 72
  • Feature Type
    protein coding gene
  • IDs
    MGI:3583957
    NCBI Gene: 546144
  • Gene Overview
    MyGene.info: WDR72
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:74110331-74283203 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 41.06 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1395 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3583957
protein coding gene Chr9:74110331-74283308 (.)
129S1/SvImJ MGP_129S1SvImJ_G0035030
protein coding gene Chr9:74360090-74534039 (+)
A/J MGP_AJ_G0035011
protein coding gene Chr9:71764311-71939194 (+)
AKR/J MGP_AKRJ_G0034940
protein coding gene Chr9:73481656-73660590 (+)
BALB/cJ MGP_BALBcJ_G0035003
protein coding gene Chr9:71447746-71621194 (+)
C3H/HeJ MGP_C3HHeJ_G0034712
protein coding gene Chr9:73957298-74134568 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035522
protein coding gene Chr9:76319136-76499097 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032433
protein coding gene Chr9:71161301-71330425 (+)
CAST/EiJ MGP_CASTEiJ_G0034034
protein coding gene Chr9:74284998-74473282 (+)
CBA/J MGP_CBAJ_G0034685
protein coding gene Chr9:78947556-79133226 (+)
DBA/2J MGP_DBA2J_G0034844
protein coding gene Chr9:71443664-71618825 (+)
FVB/NJ MGP_FVBNJ_G0034786
protein coding gene Chr9:70770259-70940792 (+)
LP/J MGP_LPJ_G0034925
protein coding gene Chr9:74614146-74794531 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034827
protein coding gene Chr9:80088168-80278738 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035544
protein coding gene Chr9:73645137-73826787 (+)
PWK/PhJ MGP_PWKPhJ_G0033738
protein coding gene Chr9:71729666-71905720 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033571
protein coding gene Chr9:73888758-74068669 (+)
WSB/EiJ MGP_WSBEiJ_G0034146
protein coding gene Chr9:73558698-73740629 (+)



Homology
more
  • Human Ortholog
    WDR72, WD repeat domain 72
  • Vertebrate Orthologs
    9
  • Human Ortholog
    WDR72, WD repeat domain 72
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AI2A3
  • Links
    NCBI Gene ID: 256764
    neXtProt AC: NX_Q3MJ13
    UniProt: Q3MJ13

  • Chr Location
    15q21.3; chr15:53513741-53762878 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Wdr72 mouse models; 1 with human WDR72 associations

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele display hypomineralized enamel, ameloblast abnormalities and decreased post-weaning body weight.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 546144 NCBI Gene Model | MGI Sequence Detail 172873 C57BL/6J ±  kb
transcript NM_001033500 RefSeq | MGI Sequence Detail 5234 C57BL/6  
polypeptide D3YYM4 UniProt | EBI | MGI Sequence Detail 1114 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    5 Sequences
  • InterPro Domains
    IPR011047 Quinoprotein alcohol dehydrogenase-like superfamily
    IPR011044 Quinoprotein amine dehydrogenase, beta chain-like
    IPR001680 WD40 repeat
    IPR019775 WD40 repeat, conserved site
    IPR017986 WD40-repeat-containing domain
    IPR036322 WD40-repeat-containing domain superfamily
    IPR015943 WD40/YVTN repeat-like-containing domain superfamily
Molecular
Reagents
less
  • All nucleic 14
    cDNA 14

    Microarray probesets 2
Other
Accession IDs
less
MGI:2143335
References
more
  • Summaries
    All 27
    Diseases 1
    Gene Ontology 3
    Phenotypes 7
  • Earliest
    J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
  • Latest
    J:242792 Wang SK, et al., Critical roles for WDR72 in calcium transport and matrix protein removal during enamel maturation. Mol Genet Genomic Med. 2015 Jul;3(4):302-19

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory