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Elmod1 Gene Detail
Summary
  • Symbol
    Elmod1
  • Name
    ELMO/CED-12 domain containing 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:3583900
    NCBI Gene: 270162
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr9:53911457-53975301 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      63845 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 29.35 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    ELMOD1, ELMO domain containing 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ELMOD1, ELMO domain containing 1
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 55531
    neXtProt AC: NX_Q8N336
    UniProt: Q8N336

  • Chr Location
    11q22.3; chr11:107591091-107666779 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 10280
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: ELMOD1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    46 phenotypes from 3 alleles in 3 genetic backgrounds
    2 images
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a spontaneous allele exhibit circling, absent startle reflex, deafness, organ of Corti degeneration and abnormal cochlear hair stereociliary bundle.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000041986 Ensembl Gene Model | MGI Sequence Detail 63845 C57BL/6J ±  kb
    transcript ENSMUST00000048409 Ensembl | MGI Sequence Detail 2605 Not Applicable  
    polypeptide ENSMUSP00000046191 Ensembl | MGI Sequence Detail 326 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      602 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • InterPro Domains
      IPR006816 ELMO domain
      IPR030722 ELMO domain-containing protein 1
    Molecular
    Reagents
    less
    • All nucleic 10
      cDNA 7
      Primer pair 3

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:2143043, MGI:2143123
    References
    more
    • Summaries
      All 29
      Developmental Gene Expression 4
      Gene Ontology 2
      Phenotypes 9
    • Earliest
      J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
    • Latest
      J:258238 Krey JF, et al., ELMOD1 Stimulates ARF6-GTP Hydrolysis to Stabilize Apical Structures in Developing Vestibular Hair Cells. J Neurosci. 2018 Jan 24;38(4):843-857

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory