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Elmod1
Gene Detail
Symbol

Name
ID
Elmod1
ELMO/CED-12 domain containing 1
MGI:3583900
Feature Type
protein coding gene
Genetic Map
Chromosome 9
29.35 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr9:53911460-53975301 bp, - strand
From Ensembl annotation of GRCm38

  63842 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10280  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ELMOD1
Gene Tree: Elmod1

Human
homologs
ELMOD1, ELMO/CED-12 domain containing 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 55531
neXtProt AC: NX_Q8N336

Human Chr (Location): 11q22.3; chr11:107591091-107666779 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(1) Spontaneous(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a spontaneous allele exhibit circling, absent startle reflex, deafness, organ of Corti degeneration and abnormal choclear hair stereociliary bundle.
 
Phenotype Images(2)
Interactions
Elmod1 interacts with 242 markers (Mir1a-1, Mir1a-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (6 annotations)
Process positive regulation of GTPase activity, positive regulation of protein targeting to mitochondrion, ...
Component cytoplasm, nucleoplasm
Function GTPase activator activity
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (77)    Tissues (9)    Images (25)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 77
cDNA source data(6)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase elmod1    NEW 
Molecular
reagents
All nucleic(8) cDNA(6) Other(2)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000041986 (Evidence)
Entrez Gene 270162 (Evidence)
DFCI TC1580709
DoTS DT.101367302, DT.110594225, DT.87072095, DT.94287825
NIA Mouse Gene Index U030878
Consensus CDS Project CCDS57678.1
International Mouse Phenotyping Consortium Status Elmod1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000041986 Ensembl Gene Model | MGI Sequence Detail 63842 C57BL/6J ±  kb
transcript ENSMUST00000048409 Ensembl | MGI Sequence Detail 2605 Not Applicable 
polypeptide ENSMUSP00000046191 Ensembl | MGI Sequence Detail 326 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(10) UniProt(6)
Polymorphisms
SNPs within 2kb(615 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006816 ELMO domain
InterPro IPR030722 ELMO domain-containing protein 1
Protein Ontology PR:000031617 ELMO domain-containing protein 1
References
(Earliest) J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
(Latest) J:187273 Johnson KR, et al., Mutations of the mouse ELMO domain containing 1 gene (Elmod1) link small GTPase signaling to actin cytoskeleton dynamics in hair cell stereocilia. PLoS One. 2012;7(4):e36074
All references(28)
Other
accession IDs
MGI:2143043, MGI:2143123

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory