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Elmod1 Gene Detail
Summary
  • Symbol
    Elmod1
  • Name
    ELMO/CED-12 domain containing 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:3583900
    NCBI Gene: 270162
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:53911457-53975301 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 29.35 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    602 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3583900
protein coding gene Chr9:53911457-53975428 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034819
protein coding gene Chr9:52954021-53014509 (-)
A/J MGP_AJ_G0034800
protein coding gene Chr9:51279279-51337379 (-)
AKR/J MGP_AKRJ_G0034728
protein coding gene Chr9:52409601-52470034 (-)
BALB/cJ MGP_BALBcJ_G0034792
protein coding gene Chr9:51030407-51091931 (-)
C3H/HeJ MGP_C3HHeJ_G0034502
protein coding gene Chr9:52882379-52943138 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035311
protein coding gene Chr9:54455153-54520551 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032223
protein coding gene Chr9:50678437-50736708 (-)
CAST/EiJ MGP_CASTEiJ_G0033824
protein coding gene Chr9:52882908-52948292 (-)
CBA/J MGP_CBAJ_G0034473
protein coding gene Chr9:56298179-56370354 (-)
DBA/2J MGP_DBA2J_G0034632
protein coding gene Chr9:51154256-51211636 (-)
FVB/NJ MGP_FVBNJ_G0034574
protein coding gene Chr9:50339917-50397944 (-)
LP/J MGP_LPJ_G0034714
protein coding gene Chr9:53262690-53323995 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034617
protein coding gene Chr9:57887267-57950136 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035333
protein coding gene Chr9:52411910-52476279 (-)
PWK/PhJ MGP_PWKPhJ_G0033528
protein coding gene Chr9:51128426-51191513 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033363
protein coding gene Chr9:52673044-52733719 (-)
WSB/EiJ MGP_WSBEiJ_G0033936
protein coding gene Chr9:52399668-52458557 (-)



Homology
more
  • Human Ortholog
    ELMOD1, ELMO domain containing 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ELMOD1, ELMO domain containing 1
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 55531
    neXtProt AC: NX_Q8N336
    UniProt: Q8N336

  • Chr Location
    11q22.3; chr11:107591091-107666779 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 10280
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: ELMOD1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    51 phenotypes from 3 alleles in 3 genetic backgrounds
    2 images
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a spontaneous allele exhibit circling, absent startle reflex, deafness, organ of Corti degeneration and abnormal cochlear hair stereociliary bundle.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000041986 Ensembl Gene Model | MGI Sequence Detail 63845 C57BL/6J ±  kb
    transcript ENSMUST00000048409 Ensembl | MGI Sequence Detail 2605 Not Applicable  
    polypeptide ENSMUSP00000046191 Ensembl | MGI Sequence Detail 326 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 8
      Primer pair 3

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:2143043, MGI:2143123
    References
    more
    • Summaries
      All 31
      Developmental Gene Expression 4
      Gene Ontology 2
      Phenotypes 10
    • Earliest
      J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
    • Latest
      J:258238 Krey JF, et al., ELMOD1 Stimulates ARF6-GTP Hydrolysis to Stabilize Apical Structures in Developing Vestibular Hair Cells. J Neurosci. 2018 Jan 24;38(4):843-857

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    Funding Information
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    last database update
    12/03/2019
    MGI 6.14
    The Jackson Laboratory