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Elmod1
Gene Detail
 Symbol
Name
ID
Elmod1
ELMO/CED-12 domain containing 1
MGI:3583900
Feature Type protein coding gene
Genetic Map
Chromosome 9
29.35 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr9:53911460-53975301 bp, - strand
From NCBI annotation of GRCm38

  63842 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10280  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Elmod1

Human
homologs
Human Homolog ELMOD1, ELMO/CED-12 domain containing 1
NCBI Gene ID 55531
neXtProt AC  NX_Q8N336
Human Chr (Location)  11q22.3; chr11:107591091-107666779 (+)  GRCh38
Alleles
and
phenotypes
All alleles(5) : Gene trapped(1) Spontaneous(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a spontaneous allele exhibit circling, absent startle reflex, deafness, organ of Corti degeneration and abnormal choclear hair stereociliary bundle.
 
Phenotype Images(2)
Gene Ontology
(GO)
classifications
All GO classifications: (4 annotations)
Process phagocytosis, positive regulation of GTPase activity
Component cytoskeleton
Function GTPase activator activity
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (77)    Tissues (9)    Images (25)
Theiler Stages: 23
Assay TypeResults
RNA in situ 77
cDNA source data(6)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(8) cDNA(6) Other(2)
Microarray probesets(2)
Other database
links
Ensembl Gene ModelENSMUSG00000041986 (Evidence)
Entrez Gene270162 (Evidence)
DFCITC1580709
DoTSDT.101367302, DT.110594225, DT.87072095, DT.94287825
NIA Mouse Gene IndexU030878
Consensus CDS ProjectCCDS57678.1
International Mouse Knockout Project StatusElmod1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 270162 NCBI Gene Model | MGI Sequence Detail 63842 C57BL/6J ±  kb
transcript NM_177769 RefSeq | MGI Sequence Detail 2605 C57BL/6 
polypeptide Q3V1U8 UniProt | EBI | MGI Sequence Detail 326 Not Applicable 

For the selected sequences
All sequences(38) RefSeq(8) UniProt(6)
Polymorphisms SNPs within 2kb(615 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006816 Engulfment/cell motility, ELMO
Protein Ontology PR:000031617 ELMO domain-containing protein 1
Graphical View of Protein Domain Structure
References (Earliest) J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
(Latest) J:187273 Johnson KR, et al., Mutations of the mouse ELMO domain containing 1 gene (Elmod1) link small GTPase signaling to actin cytoskeleton dynamics in hair cell stereocilia. PLoS One. 2012;7(4):e36074
All references(30)
Other
accession IDs
MGI:2143043, MGI:2143123

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory