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Nlrp1b Gene Detail
Summary
  • Symbol
    Nlrp1b
  • Name
    NLR family, pyrin domain containing 1B
  • Synonyms
    Nalp1b
  • Feature Type
    protein coding gene
  • IDs
    MGI:3582959
    NCBI Gene: 637515
Location & Maps
more
  • Sequence Map
    Chr11:71153102-71230733 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      77632 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    NLRP1, NLR family, pyrin domain containing 1
  • Vertebrate Orthologs
    7
  • Human Ortholog
    NLRP1, NLR family, pyrin domain containing 1
    Orthology source: HomoloGene
  • Synonyms
    CARD7, CIDED, CLR17.1, DEFCAP, DEFCAP-L/S, NAC, NALP1, PP1044, SLEV1, VAMAS1
  • Links
    NCBI Gene ID: 22861
    neXtProt AC: NX_Q9C000

  • Chr Location
    17p13.2; chr17:5501399-5584512 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Chemically induced (other)
    1
  • Targeted
    3
  • Transgenic
    1
  • Genomic Mutations
    3 involving Nlrp1b
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit protection from anthrax lethal toxin-induced lung injury and pyroptosis of macrophages.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006087 VEGA Gene Model | MGI Sequence Detail 77632 C57BL/6J ±  kb
transcript OTTMUST00000084418 VEGA | MGI Sequence Detail 4131 Not Applicable  
polypeptide OTTMUSP00000045499 VEGA | MGI Sequence Detail 1177 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    665 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 1
    cDNA 1

    Microarray probesets 1
Other
Accession IDs
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MGI:3641853, MGI:3712674
References
more
  • Summaries
    All 18
    Gene Ontology 5
    Phenotypes 17
  • Earliest
    J:99748 Boyden ED, et al., Nalp1b controls mouse macrophage susceptibility to anthrax lethal toxin. Nat Genet. 2006;38(2):240-244
  • Latest
    J:192547 Liao KC, et al., Activation of the nlrp1b inflammasome by reduction of cytosolic ATP. Infect Immun. 2013 Feb;81(2):570-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory