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Nlrp1b
Gene Detail
Symbol

Name
ID
Nlrp1b
NLR family, pyrin domain containing 1B
MGI:3582959
Synonyms
Nalp1b
Feature Type
protein coding gene
Genetic Map
Chromosome 11
43.23 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:71153102-71230733 bp, - strand
From VEGA annotation of GRCm38

  77632 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:19080  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Nlrp1b

Human
homologs
Human Homolog NLRP1, NLR family, pyrin domain containing 1
NCBI Gene ID 22861
neXtProt AC  NX_Q9C000
Human Synonyms  CARD7, CIDED, CLR17.1, DEFCAP, DEFCAP-L/S, NAC, NALP1, PP1044, SLEV1, VAMAS1
Human Chr (Location)  17p13.2; chr17:5501399-5584512 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human NLRP1
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Genomic Mutations involving Nlrp1b (1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit protection from anthrax lethal toxin-induced lung injury and pyroptosis of macrophages.
 
Interactions
Nlrp1b interacts with 298 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
Expression
cDNA source data(1)
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(1) cDNA(1)
Microarray probesets(1)
Other database
links
VEGA Gene ModelOTTMUSG00000006087 (Evidence)
Ensembl Gene ModelENSMUSG00000070390 (Evidence)
Entrez Gene637515 (Evidence)
UniGene390402
DFCITC1592946, TC1594761, TC1595426
DoTSDT.110539619, DT.110539620, DT.110539623, DT.110539624, DT.110539626
NIA Mouse Gene IndexU113333
Consensus CDS ProjectCCDS36210.1, CCDS48839.1
International Mouse Knockout Project StatusNlrp1b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006087 VEGA Gene Model | MGI Sequence Detail 77632 C57BL/6J ±  kb
transcript OTTMUST00000084418 VEGA | MGI Sequence Detail 4131 Not Applicable 
polypeptide OTTMUSP00000045499 VEGA | MGI Sequence Detail 1177 Not Applicable 

For the selected sequences
All sequences(87) RefSeq(26) UniProt(9)
Polymorphisms
SNPs within 2kb(684 from dbSNP Build 137)    SNPs within 2kb including multiple locations(786)
Protein-related
information
ResourceIDDescription
InterPro IPR001315 Caspase Recruitment
InterPro IPR011029 Death-like domain
InterPro IPR000767 Disease resistance protein
InterPro IPR025307 FIIND domain
InterPro IPR007111 NACHT nucleoside triphosphatase
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
References
(Earliest) J:99748 Boyden ED, et al., Nalp1b controls mouse macrophage susceptibility to anthrax lethal toxin. Nat Genet. 2006;38(2):240-244
(Latest) J:192547 Liao KC, et al., Activation of the nlrp1b inflammasome by reduction of cytosolic ATP. Infect Immun. 2013 Feb;81(2):570-9
All references(20)
Other
accession IDs
MGI:3641853, MGI:3712674

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory